Effects of intravenous administration of lactated Ringer's solution on hematologic, serum biochemical, rheological, hemodynamic, and renal measurements in healthy isoflurane-anesthetized dogs

Abstract

Conventional IV infusion rates of LRS to isoflurane-anesthetized dogs decreased colligative blood components; increased plasma volume, pulmonary artery pressure, and cardiac output; and did not change urine production or oxygen delivery to tissues.

Acid-base balance during volatile and total intravenous anaesthesia in dogs

“…The alpha-2 agonist, medetomidine was used for premedication in both groups in the same dose. Arterial blood pH, pO 2 and pCO 2 values were not altered regardless of the infusion rate of Ringers Lactate solution, at rates of 0, 10, 20 or 30 mL/kg/h in healthy dogs anesthetized with alpha-2 agonist and isoflurane (MUIR et al, 2011). In the current study, the infusion rate of 0.9% saline solution was 10 mL/kg/h in both groups, and is unlikely to affect pH, pO 2 and pCO 2 .…”

Colloid Osmotic Pressure and Osmolality Monitoring

“…In those given the solution at rates of 20 or 30 ml/kg/hr significant decreases in COP were measured at 30 and 60 minutes compared with baseline. 7 Whether this information translates into predictable clinical sequelae is not well studied and most likely depends on other Starling's forces.…”

Hemodynamic Effects of 6% Hydroxyethyl Starch Infusion in Sevoflurane-Anesthetized Thoroughbred Horses

“…Fluid overload could result in marked hemodilution which leads to interstitial and pulmonary edema [7,10,15]. However, no apparent clinical signs associated with fluid overload, such as nasal discharge or chemosis, were developed in any horses.…”

“…However, it is clinically difficult to administer large volumes of fluids in a short duration in large animals. Moreover, rapid administration of large volumes of crystalloids can result in hemodilution of blood constituents and increase the risk of interstitial and pulmonary edema [7,15].The administration of colloidal solutions, in particular 6% hydroxyethyl starch (HES) solution, for the treatment of hypovolemia and hypotension is becoming increasingly popular in veterinary practice. Colloid solutions are retained within the vascular compartment after administration, thereby reducing the total fluid requirement, prolonging volume expansion and improving peripheral blood flow [3,13].…”

“…However, it is clinically difficult to administer large volumes of fluids in a short duration in large animals. Moreover, rapid administration of large volumes of crystalloids can result in hemodilution of blood constituents and increase the risk of interstitial and pulmonary edema [7,15].…”