Effects of intravenous and oral propantheline and metoclopramide on ethanol absorption

Gibbons, David O.; Lant, A. F.

doi:10.1002/cpt1975175578

Cited by 34 publications

(17 citation statements)

References 8 publications

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“…Antimuscarinic drugs like pirenzepine and propantheline have anticholinergic activity and reduce gastrointestinal motility and stomach-emptying rate (3,5,9,30,43).…”

Section: Discussionmentioning

confidence: 99%

Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid

Deppermann

Lode

Höffken

et al. 1989

Antimicrob Agents Chemother

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Two randomized double-blind crossover studies and one randomized crossover study were performed to document possible drug-drug interactions between antacids (aluminum magnesium hydroxide, 10 ml per dose for 10 doses), antimuscarinic drugs (pirenzepine, 50 mg per dose for 4 doses), and H2-blockers (ranitidine, 150 mg per dose for 3 doses) and amoxicillin (1,000 mg), cephalexin (1,000 mg), doxycycline (200 mg), and amoxicillin-clavulanic acid (625 mg). Ten healthy volunteers participated in each study. Concentrations in serum and urine were measured by bioassay, and pharmacokinetic parameters were calculated by the usual open one-or two-compartment models (statistics were determined by the Wilcoxon test). The antacid, pirenzepine, and ranitidine had no influence on the bioavailability of amoxicillin, cephalexin, and amoxicillinclavulanic acid. Only small differences could be observed in the pharmacokinetic parameters, but they are not of therapeutic importance. However, the antacid caused a significant (P < 0.01) reduction in the gastrointestinal absorption of doxycycline (area under the concentration-time curve, 38.6 + 22.7 mg * h/liter, fasting; 6.0 + 3.2 mg. h/liter, with antacid), resulting in subtherapeutic levels of doxycycline.

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“…Antimuscarinic drugs like pirenzepine and propantheline have anticholinergic activity and reduce gastrointestinal motility and stomach-emptying rate (3,5,9,30,43).…”

Section: Discussionmentioning

confidence: 99%

Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid

Deppermann

Lode

Höffken

et al. 1989

Antimicrob Agents Chemother

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“…Propantheline and metocJopramide have been shown to retard and accelerate, respectively, the absorption of tetracycline, pivampicillin (Gothonl et al, 1972) and alcohol (Finch et al, 1974;Gibbons and Lant, 1975). MetocJopramide was effective by the intravenous or oral route whereas propantheline was without signifIcant effect when given orally.…”

Section: Gastric Emptying and Drug Absorptionmentioning

confidence: 94%

“…Intramuscular or intravenous metoclopramide increased the rate of aspirin , paracetamol and alcohol absorption, and oral metoclopramide also increased the rate of alcohol (Gibbons and Lant, 1975) and tetracycline absorption (Nimmo, 1973). However, it had no effect on the plasma con- Delayed absorption and failure of hypnotic action in rats Delayed absorption centration curves of p-aminosalicylic acid in healthy subjects when given orally at the same time (Scalabrino and Pasquariello, 1968).…”

Section: Effect Of Metoclopramidementioning

confidence: 97%

Drugs, Diseases and Altered Gastric Emptying

Nimmo¹

1976

Clinical Pharmacokinetics

199

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Drugs are usually given orally. They are not absorbed to any extent from the stomach but may be absorbed very rapidly from the small intestine. Thus factors influencing the rate of gastric emptying may alter the rate of absorption of most if not all orally administered drugs. Food, hormones, posture, peritoneal irritation, severe pain, gastric ulcer, diabetes and other metabolic diseases, as well as drugs such as alcohol, anticholinergics, narcotic analgesics, ganglion blocking drugs, antacids and metoclopramide all influence the rate of gastric emptying and they will, in turn, change the rate of absorption of another drug. In most instances, increasing the rate of gastric emptying and gastro-intestinal motility increases the rate of absorption of a drug but, for digoxin and riboflavin, increased gastrointestinal motility is associated with a decrease in the rate of absorption. Delayed drug absorption due to altered gastric emptying usually results in therapeutic failure, especially if the drug has a short biological half-life. At present it is not possible to predict accurately the magnitude and clinical relevance of all drug absorption interactions.

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“…In addition, the effect of the drug on gastric emptying is not apparent under some test conditions in normals (Ramsbottom & Hunt, 1970) but clear in others (Kreel et al, 1972). The measurement of drug (Heading, Nimmo, Prescott & Tothill, 1973) or ethanol (Finch, Kendall & Mitchard, 1974;Gibbons & Lant, 1975) absorption is an index of gastric emptying rate. We have used ethanol absorption as a method of measuring gastric emptying.…”

Section: Lcebo Prolactinmentioning

confidence: 99%

Pharmacokinetic and concentration‐effect studies with intravenous metoclopramide.

Bateman¹,

Kahn²,

Mashiter³

et al. 1978

Brit J Clinical Pharma

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1 Pharmacokinetic and concentration‐effect studies have been carried out following intravenous injection of 10 mg metoclopramide hydrochloride to seven normal male volunteers. 2 It is proposed that a two‐compartment model adequately describes the disposition of the drug which is rapidly distributed (T1/2alpha = 4.9 +/‐ 1.1 min) and eliminated (T1/2beta = 165.7 +/‐ 20.2 min). Total body plasma clearance of the drug is high (10.9 +/‐ 1.5 ml min‐1 kg‐1) and approximates to liver plasma flow. 3 Metoclopramide i.v. increases gastric emptying as measured by an ethanol absorption test (P less than 0.005). The duration of this effect is at least 3 h. 4 Ethanol given after i.v. metoclopramide administration produces significant sedation during the first hour and at 3 h (P less than 0.001). 5 The effect of metoclopramide on gastric emptying, and the degree of sedation induced by ethanol would appear to be related to plasma metoclopramide concentration. 6 Metoclopramide increases serum prolactin to 59 +/‐ 5.8 microgram/1 at 30 min after injection. There is a linear relationship (r = 0.809) between serum prolactin increase and plasma metoclopramide concentration.

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Effects of intravenous and oral propantheline and metoclopramide on ethanol absorption

Cited by 34 publications

References 8 publications

Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid

Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid

Drugs, Diseases and Altered Gastric Emptying

Pharmacokinetic and concentration‐effect studies with intravenous metoclopramide.

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