Effects of intravenous diclofenac on postoperative sore throat in patients undergoing laparoscopic surgery at Aga Khan University Hospital, Nairobi: A prospective, randomized, double blind controlled trial

Thang’a, P; Kamya, Dorothy; Mung’ayi, Vitalis

doi:10.4314/ahs.v13i4.20

Cited by 10 publications

(10 citation statements)

References 44 publications

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“…The anti-inflammatory efficacy of NSAID in prevention of POST has been demonstrated for topical application of a diclofenac patch, transdermal ketoprofen or gargling with benzydamine before induction of anesthesia [ 16 17 18 ]. In contrast, a single dose of IV diclofenac 75 mg at induction of anesthesia failed to reduce the incidence or severity of sore throat during the first 18 hours after laparoscopic surgery [ 19 ]. The authors assumed that IV administration may result in a lower drug concentration than topical application, which lead to the lack of benefit from diclofenac in their study.…”

Section: Discussionmentioning

confidence: 99%

The effect of ketorolac and dexamethasone on the incidence of sore throat in women after thyroidectomy: a prospective double-blinded randomized trial

Yang

Jung

Bae

et al. 2017

Korean J Anesthesiol

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BackgroundWe evaluated the effect of two drugs with anti-inflammatory action, dexamethasone and ketorolac, on reduction of postoperative sore throat (POST) after general anesthesia with endotracheal intubation in patients undergoing thyroidectomy.MethodsOne hundred and ninety-two female patients scheduled to undergo general anesthesia with endotracheal intubation for thyroidectomy were enrolled in this prospective study. Participants were randomly allocated to receive intravenous medication; placebo (Group C, n = 45), ketorolac 30 mg immediately before intubation (Group Kpre, n = 47), ketorolac 30 mg at the end of surgery (Group Kpost, n = 45) and dexamethasone 10 mg (Group D, n = 43). The incidence and severity of POST and hoarseness were evaluated at 1, 6 and 24 hours after surgery.ResultsIncidences and severities of POST at rest and during swallowing in first 6 hours after extubation were comparable among 4 groups. At 24 hours postextubation, the incidence (P = 0.002, 95% CI of proportion differences; 0.05–0.39) and severity (P = 0.008) of POST during swallowing were significantly lower in group D than in group C. Kpre and Kpost groups did not show a greater reduction in POST than group C, despite lower rescue analgesic requirement at 1 hour after extubation in group Kpre (P = 0.006; 95% CI of proportion differences; 0.07–0.38). No intergroup differences were observed in incidences of hoarseness or adverse events.ConclusionsIntravenous administration of dexamethasone 10 mg, but not ketorolac, before induction of anesthesia reduces the incidence and severity of POST during swallowing at 24 hours after thyroidectomy.

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Section: Discussionmentioning

confidence: 99%

The effect of ketorolac and dexamethasone on the incidence of sore throat in women after thyroidectomy: a prospective double-blinded randomized trial

Yang

Jung

Bae

et al. 2017

Korean J Anesthesiol

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“…A preoperative 350 mg aspirin gargle reduced postoperative sore throat, but only for 2 h [29]. Intravenous diclofenac had no effect in patients undergoing laparoscopic surgery [30], although topical diclofenac reduced the incidence of sore throat following caesarean section [31].…”

Section: Non-steroidal Anti-inflammatory Drugs (Nsaids)mentioning

confidence: 98%

Postoperative sore throat: a systematic review

2016

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Summary Postoperative sore throat has a reported incidence of up to 62% following general anaesthesia. In adults undergoing tracheal intubation, female sex, younger age, pre‐existing lung disease, prolonged duration of anaesthesia and the presence of a blood‐stained tracheal tube on extubation are associated with the greatest risk. Tracheal intubation without neuromuscular blockade, use of double‐lumen tubes, as well as high tracheal tube cuff pressures may also increase the risk of postoperative sore throat. The expertise of the anaesthetist performing tracheal intubation appears to have no influence on the incidence in adults, although it may in children. In adults, the i‐gel™ supraglottic airway device results in a lower incidence of postoperative sore throat. Cuffed supraglottic airway devices should be inflated sufficiently to obtain an adequate seal and intracuff pressure should be monitored. Children with respiratory tract disease are at increased risk. The use of supraglottic airway devices, oral, rather than nasal, tracheal intubation and cuffed, rather than uncuffed, tracheal tubes have benefit in reducing the incidence of postoperative sore throat in children. Limiting both tracheal tube and supraglottic airway device cuff pressure may also reduce the incidence.

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“…But in this study the use of singledose pregabalin could not reduce sore throat after intubation. In placebo-controlled clinical trial conducted by Thang et al [16], 42 patients undergoing laparoscopy, single dose of intravenous diclofenac was studied in the prevention of sore throat after extubated. There was no significant difference (P value respectively 0.361, 0.678, and 862) between the A and B groups after 2, 6, and 18 hours.…”

Section: Discussionmentioning

confidence: 99%

Effect of Single Dose of Pregabalin on Post Tracheal Intubation Sore Throat after General Anesthesia

Anvari

Kazaj

Kolahdouzan

et al. 2019

AACC

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Background: Sore throat is one of the major complications of tracheal intubation after general anesthesia. Pregabalin is an analgesic, the anti neuropathic pain and analgesic effects of which have been demonstrated in various studies. This study examined the effects of single dose pregabalin one hour before tracheal intubation, to prevent sore throat after extubation. Methods: In a double-blind, randomized clinical trial, 60 patients who had undergone general and urologic surgeries at Imam Reza hospital in Tabriz, Iran, since March to July 2015 that required tracheal intubation, were included in the study. The patients were randomly divided into two groups (group A, 30 patients and group B, 30 patients). In the group A, an hour before anesthesia, one pregabalin tablet (300mg) was given to the patients. For the patients of the group B, the placebo was given. After awareness of patients, the severity of sore throat was measured and recorded by VAS scale after 2, 6 and 24 hours of the surgery. Results: Severity and incidence of sore throat after tracheal intubation were not significantly different between two groups. Meanwhile, no side effects of pregabalin were observed in the group A. Conclusion: Administration of pregabalin as a single dose of 300 mg one hour prior to anesthesia and intubation decreased the incidence and severity of sore throat in the case group than the control group, although the amount of this reduction was not statistically significant between the two groups.

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Effects of intravenous diclofenac on postoperative sore throat in patients undergoing laparoscopic surgery at Aga Khan University Hospital, Nairobi: A prospective, randomized, double blind controlled trial

Cited by 10 publications

References 44 publications

The effect of ketorolac and dexamethasone on the incidence of sore throat in women after thyroidectomy: a prospective double-blinded randomized trial

The effect of ketorolac and dexamethasone on the incidence of sore throat in women after thyroidectomy: a prospective double-blinded randomized trial

Postoperative sore throat: a systematic review

Effect of Single Dose of Pregabalin on Post Tracheal Intubation Sore Throat after General Anesthesia

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