1982
DOI: 10.1016/0002-8703(82)90561-0
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Effects of intravenous fluorocarbons during and without oxygen enhancement on acute myocardial ischemic injury assessed by measurement of intramyocardial gas tensions

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Cited by 46 publications
(4 citation statements)
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“…Adult, male mongrel dogs (body weight, [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] During maintained autoregulation (group B), circumflex artery pressure-flow relations before and after PFC hemodilution were initially measured with the electromagnetic flow probe. Thereafter, each autoregulatory pressure-flow relation was repeated, and radiolabeled microspheres were injected before and after PFC hemodilution at four points on the coronary pressure-flow relation: at control coronary blood flow, at the LPL, at the coronary perfusion pressure that produced a coronary blood flow level at 75%, and at 50% of control circumflex artery blood flow.…”
Section: Materials and Methods Animal Preprarationmentioning
confidence: 99%
“…Adult, male mongrel dogs (body weight, [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] During maintained autoregulation (group B), circumflex artery pressure-flow relations before and after PFC hemodilution were initially measured with the electromagnetic flow probe. Thereafter, each autoregulatory pressure-flow relation was repeated, and radiolabeled microspheres were injected before and after PFC hemodilution at four points on the coronary pressure-flow relation: at control coronary blood flow, at the LPL, at the coronary perfusion pressure that produced a coronary blood flow level at 75%, and at 50% of control circumflex artery blood flow.…”
Section: Materials and Methods Animal Preprarationmentioning
confidence: 99%
“…Unlike hemoglobin, the oxygen content of perfluorochemicals rises in linear fashion with an increase in oxygen tension and a high arterial oxygen is essential for perfluorochemicals to transport quantities of oxygen comparable to those transported by red blood cells.25 36 One preparation of perfluorochemical (Fluosol-DA 20%) has been used successfully in the United States and Japan in anemic patients as a blood substitute. 20 25 Studies in several animal preparations have suggested that use of perfluorochemicals may be an effective form of therapy for reducing experimental myocardial ischemia.23 27 Prevention of myocardial ischemia for up to 45 min has also been demonstrated during percutaneous transluminal balloon occlusion in dogs given perfluorochemical.26 These studies suggest a potential role for perfluorochemical as a therapeutic agent in the treatment of myocardial infarction.…”
Section: Methodsmentioning
confidence: 99%
“…-10 However, reperfusion can result in morphologic and metabolic derangements (so-called reperfusion injury) that may reduce the amount of myocardium that can be salvaged.1 I"' Perfluorochemicals are substances that may be useful in treating ischemia because of their high oxygen-carrying capacity. [19][20][21][22] Reduction of infarct size with perfluorochemicals has been shown by others,23 27 but previously the drugs were either used in a preparation of permanent occlusion or were studied only after brief periods of ischemia. Since large intravenous doses of perfluorochemicals were used in these studies, an exchange blood transfusion was required to prevent volume overload.…”
mentioning
confidence: 99%
“…This, combined with the very small particle size in the emulsion, may explain their ability to improve tissue oxygenation in the presence of ischaemic hypoxia during myocardial infarction (Biro 1983;Rude et al 1982;Faithfull et al 1985), cerebral infarction (Sutherland et al 1984) and during perfusion of extremities following prolonged traumatic amputation (Smith et al 1985). This, combined with the very small particle size in the emulsion, may explain their ability to improve tissue oxygenation in the presence of ischaemic hypoxia during myocardial infarction (Biro 1983;Rude et al 1982;Faithfull et al 1985), cerebral infarction (Sutherland et al 1984) and during perfusion of extremities following prolonged traumatic amputation (Smith et al 1985).…”
Section: Introductionmentioning
confidence: 99%