2011
DOI: 10.1111/j.1537-2995.2010.02783.x
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Effects of intravenous iron combined with low‐dose recombinant human erythropoietin on transfusion requirements in iron‐deficient patients undergoing bilateral total knee replacement arthroplasty (CME)

Abstract: Treatment with parenteral iron and low-dose rHuEPO-β in bilateral TKRA effectively attenuated anemia and decreased transfusion requirements in iron-deficient patients.

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Cited by 81 publications
(96 citation statements)
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References 34 publications
(72 reference statements)
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“…68 A small study of intra-and postoperative intravenous iron and erythropoietin administration in patients undergoing elective bilateral total knee replacement also showed favourable results on reducing postoperative transfusions in the six weeks following surgery. 69 In elective colorectal 70 and gynaecological 71 surgical populations, contradictory results exist regarding the impact of intravenous iron in improving postoperative haemoglobin. The timing of iron administration in these studies differed (iron administered two weeks earlier in the hysterectomy study) which may account for the discrepancy in results with no benefit on postoperative haemoglobin seen in the colorectal group.…”
Section: Elective Surgerymentioning
confidence: 99%
“…68 A small study of intra-and postoperative intravenous iron and erythropoietin administration in patients undergoing elective bilateral total knee replacement also showed favourable results on reducing postoperative transfusions in the six weeks following surgery. 69 In elective colorectal 70 and gynaecological 71 surgical populations, contradictory results exist regarding the impact of intravenous iron in improving postoperative haemoglobin. The timing of iron administration in these studies differed (iron administered two weeks earlier in the hysterectomy study) which may account for the discrepancy in results with no benefit on postoperative haemoglobin seen in the colorectal group.…”
Section: Elective Surgerymentioning
confidence: 99%
“…10,49,[53][54][55][56] In these patient populations, ESAs have been shown to increase Hb levels, reduce allogeneic transfusion, increase aerobic capacity, and improve quality of life. 57 The ability of ESAs to reduce transfusions has been balanced by recent concerns of increased adverse outcomes (thrombosis, cancer progression) associated with ESA therapy in patients undergoing spine surgery and in patients with chronic renal failure and Sources: O'Brien et al 44 Vamvakas et al 43 RBC = red blood cells; HIV = human immunodeficiency virus; HCV = hepatitis C virus; HBV = hepatitis B virus; HTLV = Human T-cell leukemia/lymphoma virus; WNV = West Nile virus cancer.…”
Section: Use Of Esas To Treat Anemiamentioning
confidence: 99%
“…10 In addition, clinical studies suggest that brief and/or low-dose treatment of anemic perioperative patients with ESAs may be a safe and effective means of increasing red cell mass and avoiding red cell transfusion. 48,49,55 Future studies are required to determine if aggressive treatment of anemia can improve patient outcomes following other types of surgery.…”
Section: Use Of Esas To Treat Anemiamentioning
confidence: 99%
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“…21 22 This may be a useful concept in orthopaedic surgery. 23 For the reduction in perioperative blood loss, a bundle of measures needs to be combined ( Table 1). The most important is a meticulous surgical technique aiming at minimizing blood loss.…”
mentioning
confidence: 99%