Effects of intravenous lipid emulsions on the reversal of pacing-induced ventricular arrhythmias and electrophysiological alterations in an animal model of ropivacaine toxicity

Zaballos, M.; Fernández, Ignacio; Rodríguez, Lucia; García, S.; Varela, Olalla Cortizas; Quintela, Óscar; Anadón, M.J.; Almendral, Jesús

doi:10.1080/15563650.2022.2080075

Cited by 2 publications

(2 citation statements)

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“…Lipid emulsion resuscitation therapy is recommended for the treatment of lipophilic drug overdoses; specifically, lipid emulsions (LE) are administered intravenously as non-specific antidotes, in the form of an "oil-in-water" type of drops [ 35 ]. LEs have been used for overdose treatment and to reduce the concentration of lipophilic antiarrhythmic, psychotropic, antimalarial drugs, local anesthetics, calcium channel blockers such as propranolol [ 36 ], cocaine [ 37 , 38 ], diltiazem [ 39 ], buprenorphine, fentanyl and butorphanol [ 40 ], bupivacaine [ 41 ], ivermectin [ 42 , 43 ], and ropivacaine [ 44 , 45 ]. LEs rapidly decrease the threshold for seizure activity, amoxapine toxicity [ 46 ], and improve cardiac activity during heart transplantation [ 47 ].…”

Section: Types Of Nanodevices For Detoxification In Medicinementioning

confidence: 99%

“…Известно, что при передозировке липофильных препаратов рекомендуется применение липидной реанимационной терапии, а именно, использование в качестве неспецифических антидотов липидных эмульсий (ЛЭ) -внутривенно вводимых наноразмерных капель типа «масло в воде» [35]. ЛЭ применяют при передозировке и для снижения концентрации липофильных антиаритмических, психотропных, противомалярийных препаратов, местных анестетиков, блокаторов кальциевых каналов, таких, как пропранолол [36], кокаин [37,38], дилтиазем [39], бупренорфин, фентанил и буторфанол [40], бупивакаин [41], ивермектин [42,43], ропивакаин [44,45]. Использование ЛЭ быстро снижает порог судорожной активности, токсичности амоксапина [46], улучшает сердечную деятельность при трансплантации сердца [47].…”

Section: типы наноустройств для детоксикации в медицинеunclassified

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Biomedical Nanosystems for <i>in vivo</i> Detoxification: From Passive Delivery Systems to Functional Nanodevices and Nanorobots

et al. 2023

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The problem of low efficiency of nanotherapeutic drugs challenges the creation of new alternative biomedical nanosystems known as robotic nanodevices. In addition to encapsulating properties, nanodevices can perform different biomedical functions, such as precision surgery, in vivo detection and imaging, biosensing, targeted delivery, and, more recently, detoxification of endogenous and xenobiotic compounds. Nanodevices for detoxification are aimed at removing toxic molecules from biological tissues, using a chemical- and/or enzyme-containing nanocarrier for the toxicant to diffuse inside the nanobody. This strategy is opposite to drug delivery systems that focus on encapsulating drugs and releasing them under the influence of external factors. The review describes various kinds of nanodevices intended for detoxification that differ by the type of poisoning treatment they provide, as well as the type of materials and toxicants. The final part of the review is devoted to enzyme nanosystems, an emerging area of research that provides fast and effective neutralization of toxins in vivo.

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Section: Types Of Nanodevices For Detoxification In Medicinementioning

confidence: 99%

Section: типы наноустройств для детоксикации в медицинеunclassified

Biomedical Nanosystems for <i>in vivo</i> Detoxification: From Passive Delivery Systems to Functional Nanodevices and Nanorobots

et al. 2023

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The Expanding Role of Pyridine Derivatives as Privileged Scaffolds in Cardiac Ionic Channels

Janapati¹,

Cheweti²,

Chidipi³

et al. 2023

Exploring Chemistry With Pyridine Derivatives

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Pyridine-based ring systems are heterocycle-structured subunits that are being abundantly employed in drug design, primarily because of their tremendous effect on pharmacological activity, which has resulted in the discovery of various broad-spectrum medicinal compounds. Pyridine derivatives are employed to treat multiple medical illnesses, including prostate cancer, AIDS, tuberculosis, angina, ulcer, arthritis, urinary tract analgesic, Alzheimer’s disease, and cardiovascular diseases. This chapter emphasized the currently available synthetic pyridine derivatives, including nimodipine, ciclopirox, efonidipine, nifedipine, milrinone, and amrinone, effects on cardiac ionic channels and their mechanisms of action for the cure. Pyridine derivatives regulate several voltage-gated ion channel behaviors, including sodium (Nav), calcium (Cav), and potassium (Kv) channels, and are set as a therapeutic approach. Particularly, calcium-channel blockers are the most common action of medicines with a dihydropyridine ring and are often used to treat hypertension and heart-related problems. Finally, this chapter gives the prospects of highly potent bioactive molecules to emphasize the advantages of using pyridine and dihydropyridine in drug design. This chapter discusses pyridine derivatives acting on cardiac ionic channels to combat CVS diseases. The book chapter describes the importance of pyridine derivatives as a novel class of medications for treating cardiovascular disorders.

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Effects of intravenous lipid emulsions on the reversal of pacing-induced ventricular arrhythmias and electrophysiological alterations in an animal model of ropivacaine toxicity

Cited by 2 publications

References 38 publications

Biomedical Nanosystems for <i>in vivo</i> Detoxification: From Passive Delivery Systems to Functional Nanodevices and Nanorobots

Biomedical Nanosystems for <i>in vivo</i> Detoxification: From Passive Delivery Systems to Functional Nanodevices and Nanorobots

The Expanding Role of Pyridine Derivatives as Privileged Scaffolds in Cardiac Ionic Channels

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