Effects of intraventricular injections of 6-hydroxydopamine on amine metabolites in rat brain and urine

Edwards, David J.; Ravitch, Joshua; Knopf, Steven; Sedlock, M.L.

doi:10.1016/0006-2952(85)90503-9

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1985

1992

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Cited by 9 publications

(1 citation statement)

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“…Substantial amounts of MHPG and HVA have been found to originate in the central nervous system (CNS) in humans and animals.1820 Homovanillic acid is reported to be a more suitable marker of brain dopamine than DOPAC. 21 Garfinkel et al22 demonstrated the higher CNS origin of 5-HIAA and MHPG in humans.…”

Section: Resultsmentioning

confidence: 99%

Plasma Monoaminergic Metabolites and Catecholamines in Subarachnoid Hemorrhage

Minegishi¹,

Ishizaki²,

Yoshida³

et al. 1987

Arch Neurol

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Section: Resultsmentioning

confidence: 99%

Plasma Monoaminergic Metabolites and Catecholamines in Subarachnoid Hemorrhage

Minegishi¹,

Ishizaki²,

Yoshida³

et al. 1987

Arch Neurol

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Effects of Drugs on Octopamine Metabolism in the Rat

Edwards

Sedlock

1985

Neuropsychopharmacology of the Trace Amines

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Catecholamine metabolism in the vas deferens and the adrenal gland with special reference to the central catecholamine-depleted state

Yamaguchi

Nakada

1992

Experientia

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Experiments were carried out to elucidate the role of central catecholamines in regulating catecholamine metabolism in the vas deferens and adrenal gland of the rat. Rats were injected intracerebroventricularly (i.c.v.) with either vehicle or 6-hydroxydopamine (6-OHDA). Groups of animals pretreated with vehicle or 6-OHDA (i.c.v.) were injected intraperitoneally (i.p.) with alpha-methyl-para-tyrosine (AMT), a tyrosine hydroxylase inhibitor. Catecholamine turnover rates were estimated by determining norepinephrine or epinephrine content after administering AMT. Central norepinephrine and dopamine contents decreased significantly (p less than 0.05) after treatment with 6-OHDA and AMT. The norepinephrine content of the vas deferens of rats pretreated with 6-OHDA was markedly reduced (p less than 0.001) after administration of AMT, whereas that of the vehicle-treated rats remained unchanged. Administration of 6-OHDA had no effect on the norepinephrine or epinephrine content of the adrenal gland. The present results indicate that central monoaminergic neurons have an inhibitory effect on the adrenergic neurons of the vas deferens. In contrast, this inhibitory regulation does not appear to be exerted on the adrenal glands.

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Effects of intraventricular injections of 6-hydroxydopamine on amine metabolites in rat brain and urine

Cited by 9 publications

References 37 publications

Plasma Monoaminergic Metabolites and Catecholamines in Subarachnoid Hemorrhage

Plasma Monoaminergic Metabolites and Catecholamines in Subarachnoid Hemorrhage

Effects of Drugs on Octopamine Metabolism in the Rat

Catecholamine metabolism in the vas deferens and the adrenal gland with special reference to the central catecholamine-depleted state

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