Effects of Intravitreal Aflibercept on Retinal Function and Improvement of Macular Edema Associated With Diabetic Retinopathy

Ichio, Atsushi; Sugimoto, Masahiko; Matsubara, Hisashi; Mochida, Daiki; Kato, Kumiko; Kondo, Mineo

doi:10.1167/tvst.9.11.2

Cited by 4 publications

(5 citation statements)

References 43 publications

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“…The 30-Hz flicker ERG is the response of the cones (8), where the density of cone cells in the macular fovea is higher (27); therefore, only if the entire retina or the macula is involved, there is a significant change. In other words, if the macula is involved, the test becomes more sensitive and helpful to evaluate the effectiveness of treatment (28). In addition, traditional ERG examinations required dark adaptation (8) and were time consuming, while a 30-Hz flicker ERG check can be done in a few minutes.…”

Section: Discussionmentioning

confidence: 99%

A Diagnostic Model for Screening Diabetic Retinopathy Using the Hand-Held Electroretinogram Device RETeval

Deng

Zeng

et al. 2021

Front. Endocrinol.

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PurposeTo construct a proper model to screen for diabetic retinopathy (DR) with the RETeval.MethodThis was a cross-sectional study. Two hundred thirty-two diabetic patients and seventy controls were recruited. The DR risk assessment protocol was performed to obtain subjects’ DR risk score using the RETeval. Afterwards, the receiver operating characteristic (ROC) curve was used to determine the best cutoff for diagnosing DR. Random forest and decision tree models were constructed.ResultsWith increasing DR severity, the DR score gradually increased. When the DR score was used to diagnose DR, the ROC curve had an area under the curve of 0.881 (95% confidence interval: 0.836-0.927, P < 0.001), with a best cutoff value of 22.95, a sensitivity of 74.3% (95 CI: 66.0%~82.6%), and a specificity of 90.6% (95 CI: 83.7% ~94.8%). The top four risk factors selected by the random forest were used to construct the decision tree for diagnosing DR, which had a sensitivity of 93.3% (95% CI: 86.3%~97.0%) and a specificity of 80.3% (95% CI: 72.1% ~86.6%).ConclusionsThe DR risk assessment protocol combined with the decision tree model was innovatively used to evaluate the risk of DR, improving the sensitivity of diagnosis, which makes this method more suitable than the current protocol for DR screening.

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Section: Discussionmentioning

confidence: 99%

A Diagnostic Model for Screening Diabetic Retinopathy Using the Hand-Held Electroretinogram Device RETeval

Deng

Zeng

et al. 2021

Front. Endocrinol.

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“…[82][83][84] The retinal sensitivity improvement was significantly correlated with the BCVA and inversely correlated with the OCT central subfield thickness. [85][86][87][88] In addition, Santos and colleagues reported that better retinal sensitivities before treatment were associated with better BCVA outcomes after therapy. This suggested that the baseline MP findings may have prognostic value for DME treatments.…”

Section: Microperimetry In Diabetic Retinopathymentioning

confidence: 99%

“…For example, in diabetic macular edema (DME), the retinal sensitivities determined by MP coupled with optical coherence tomography (OCT) biomarkers and multifocal electroretinograms are used as functional markers for the entire macula region. Thus, earlier studies have shown that MP, together with these other methods, were able to show improvements in sensitivity following anti-VEGF therapy by ranibizumab or aflibercept in eyes with DME 6,7. Furthermore, the macular function assessed by MP combined with structural OCT angiography (OCTA) metrics and capillary dropout areas showed low sensitivities in eyes with ischemic DME 8.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, earlier studies have shown that MP, together with these other methods, were able to show improvements in sensitivity following anti-VEGF therapy by ranibizumab or aflibercept in eyes with DME. 6,7 Furthermore, the macular function assessed by MP combined with structural OCT angiography (OCTA) metrics and capillary dropout areas showed low sensitivities in eyes with ischemic DME. 8 In addition, the retinal sensitivity determined by MP and the vascular density of both the superficial and deep capillary plexuses determined by OCTA were both significantly correlated with the stage of diabetic retinopathy (DR).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, following treatment with anti-VEGF agents or intravitreal corticosteroids, improvements in retinal sensitivities have been reported 82–84. The retinal sensitivity improvement was significantly correlated with the BCVA and inversely correlated with the OCT central subfield thickness 85–88. In addition, Santos and colleagues reported that better retinal sensitivities before treatment were associated with better BCVA outcomes after therapy.…”

Section: Introductionmentioning

confidence: 99%

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Microperimetry in Retinal Diseases

Horie

Corradetti

Esmaeilkhanian

et al. 2023

Asia-Pacific Journal of Ophthalmology

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Retinal microperimetry (MP) is a procedure that assesses the retinal sensitivity while the fundus is directly observed, and an eye tracker system is active to compensate for involuntary eye movements during testing. With this system, the sensitivity of a small locus can be accurately determined, and it has become an established ophthalmic test for retinal specialists. Macular diseases are characterized by chorioretinal changes; therefore, the condition of the retina and choroid requires careful and detailed evaluations to perform effective therapy. Age-related macular degeneration is a representative retinal disease in which the macular function has been evaluated by the visual acuity throughout the course of the disease process. However, the visual acuity represents the physiological function of only the central fovea, and the function of the surrounding macular area has not been sufficiently evaluated throughout the different stages of the macula disease process. The new technique of MP can compensate for such limitations by being able to test the same sites of the macular area repeatedly. This is especially useful in the recent management of age-related macular degeneration or diabetic macular edema during anti-vascular endothelial growth factor treatments because MP can assess the effectiveness of the treatment. MP examinations are also valuable in diagnosing Stargardt disease as they can detect visual impairments before any abnormalities are found in the retinal images. The visual function needs to be carefully assessed along with morphologic observations by optical coherence tomography. In addition, the assessment of retinal sensitivity is useful in the presurgical or postsurgical evaluations.

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Case of cystoid macular edema induced by systemic administration of paclitaxel: evaluations with electroretinograms

et al. 2021

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Effects of Intravitreal Aflibercept on Retinal Function and Improvement of Macular Edema Associated With Diabetic Retinopathy

Abstract: Effects of intravitreal aflibercept on retinal function and improvement of macular edema associated with diabetic retinopathy.

Cited by 4 publications

References 43 publications

A Diagnostic Model for Screening Diabetic Retinopathy Using the Hand-Held Electroretinogram Device RETeval

A Diagnostic Model for Screening Diabetic Retinopathy Using the Hand-Held Electroretinogram Device RETeval

Microperimetry in Retinal Diseases

Case of cystoid macular edema induced by systemic administration of paclitaxel: evaluations with electroretinograms

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