Effects of Ionic and Nonionic Contrast Media on Endothelium and on Arterial Thrombus Formation

Barstad, R. M.; Buchmann, Marie; Hamers, M. J. A. G.; Örning, Lars; Ørvim, U.; Stormorken, Helge; Sakariassen, Kjell S.

doi:10.1177/02841851960373p2102

Cited by 25 publications

(8 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The nonionic isosmolar dimer iodixanol appears to have less thrombogenic potential and more favorable effects on endothelial cells than the nonionic low osmolar monomer iohexol [14]. However, iodixanol has been reported to increase platelet aggregation, whereas ioxaglate inhibits it [9].…”

Section: Discussionmentioning

confidence: 97%

Cardiac events after low osmolar ionic or isosmolar nonionic contrast media utilization in the current era of coronary angioplasty

Feuvre

Batisse

Collet

et al. 2006

Cathet Cardio Intervent

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 97%

Cardiac events after low osmolar ionic or isosmolar nonionic contrast media utilization in the current era of coronary angioplasty

Feuvre

Batisse

Collet

et al. 2006

Cathet Cardio Intervent

View full text Add to dashboard Cite

show abstract

“…CM normally induces dilation in healthy subjects [82,83], however, in CAD patients who typically exhibit endothelial dysfunction, coronary vasoconstriction or even vasospasm may occur [83,84]. In vitro studies have demonstrated that CM may exert negative effects on both EC [85,86] and VSMC [87,88]. CM is more likely to exert dose-dependent [89] vasoconstriction in segments close to a stenotic lesion [83,90], emphasizing a possible involvement of endothelial dysfunction, and constriction occurs more frequently following ionic CM than the currently used non-ionic CM [91].…”

Section: Does Contrast Media Using During Ptca/pci Cause Vascular Dysmentioning

confidence: 99%

Effects of Catheterization on Artery Function and Health: When Should Patients Start Exercising Following Their Coronary Intervention?

2019

View full text Add to dashboard Cite

Coronary artery disease (CAD) is a leading cause of death worldwide, and percutaneous transluminal coronary angiography (PTCA) and/or percutaneous coronary intervention (PCI; angioplasty) are commonly used to diagnose and/or treat the obstructed coronaries. Exercise-based rehabilitation is recommended for all CAD patients; however, most guidelines do not specify when exercise training should commence following PTCA and/or PCI. Catheterization can result in arterial dysfunction and acute injury, and given that fact that exercise, particularly at higher intensities, is associated with elevated inflammatory and oxidative stress, endothelial dysfunction and a pro-thrombotic milieu, performing exercise post-PTCA/PCI may transiently elevate the risk of cardiac events. This review aims to summarize extant literature relating to the impacts of coronary interventions on arterial function, including the time-course of recovery and the potential deleterious and/or beneficial impacts of acute versus long-term exercise. The current literature suggests that arterial dysfunction induced by catheterization recovers 4-12 weeks following catheterization. This review proposes that a period of relative arterial vulnerability may exist and exercise during this period may contribute to elevated event susceptibility. We therefore suggest that CAD patients start an exercise-training program between 2 and 4 weeks post-PCI, recognizing that the literature suggest there is a "grey area" for functional recovery between 2-12 weeks post catheterization. The timing of exercise onset should take into consideration the individual characteristics of patients (age, severity of disease, comorbidities) and the intensity, frequency and duration of the exercise prescription.

show abstract

“…The contrast medium used in our angiographies was Omni-paque® 300 (GE Healthcare, CO/ Cork, Ireland), a low osmolar, non-ionic contrast medium containing 647 mg of the active substance Iohexol per milliliter. Iohexol induces arterial endothelial changes in morphology with no effect on fibrin deposition 15 . Formed thrombi will be larger and more resistant to thrombolysis compared to saline controls 16 .…”

Section: A B D Cmentioning

confidence: 99%

Spontaneous Closure of Cerebral Dural Arteriovenous Fistulas with Direct Cortical Venous Drainage

et al. 2009

View full text Add to dashboard Cite

We describe two rare cases of spontaneous closure of cerebral dural arteriovenous fistulas (DAVFs) with a small nidus and draining directly in a single cortical vein with several ectasias. Eighteen previously published cases of spontaneous closure of cerebral DAVF comprised more benign fistula types. In literature, several explanations for DAVF occlusion have been proposed. We hypothesize that, in addition to the known causes, the specific contrast medium used during the diagnostic selective angiography might have played a role in the thrombosis and subsequent fistula closure.

show abstract

Effects of Ionic and Nonionic Contrast Media on Endothelium and on Arterial Thrombus Formation

Cited by 25 publications

References 24 publications

Cardiac events after low osmolar ionic or isosmolar nonionic contrast media utilization in the current era of coronary angioplasty

Cardiac events after low osmolar ionic or isosmolar nonionic contrast media utilization in the current era of coronary angioplasty

Effects of Catheterization on Artery Function and Health: When Should Patients Start Exercising Following Their Coronary Intervention?

Spontaneous Closure of Cerebral Dural Arteriovenous Fistulas with Direct Cortical Venous Drainage

Contact Info

Product

Resources

About