Effects of Iranian propolis on renal function, prooxidant-antioxidant balance, metabolic status, and quality of life in patients with chronic kidney disease: A study protocol of an ongoing randomized, double-blind, placebo-controlled clinical trial

Anvarifard, Paniz; Anbari, Maryam; Ostadrahimi, Alireza; Ardalan, Mohammadreza; Ghoreishi, Zohreh

doi:10.1016/j.conctc.2023.101159

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…Jespersen et al [ 53 , 54 ] determined a possible association between moderate wine consumption and a lower prevalence of CKD. Currently, Anvarifard et al [ 55 ] is assessing the effectiveness of propolis supplementation in 44 eligible CKD patients through a multi-centred, randomized, double-blind, placebo-controlled clinical trial. If the results of this study reveal the remarkable effectiveness of propolis in improving the quality of life and clinical outcomes in patients with CKD, this compound may reach a new milestone as an adjunctive therapy for CKD, and it opens a new window for further studies.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

Baptista,

Paié-Ribeiro,

Almeida

et al. 2024

Molecules

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Chronic kidney disease (CKD) presents a formidable global health concern, affecting one in six adults over 25. This review explores the potential of phenolic compounds in managing CKD and its complications. By examining the existing research, we highlight their diverse biological activities and potential to combat CKD-related issues. We analyze the nutritional benefits, bioavailability, and safety profile of these compounds. While the clinical evidence is promising, preclinical studies offer valuable insights into underlying mechanisms, optimal dosages, and potential side effects. Further research is crucial to validate the therapeutic efficacy of phenolic compounds for CKD. We advocate for continued exploration of their innovative applications in food, pharmaceuticals, and nutraceuticals. This review aims to catalyze the scientific community's efforts to leverage phenolic compounds against CKD-related challenges.

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Section: Discussionmentioning

confidence: 99%

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

Baptista,

Paié-Ribeiro,

Almeida

et al. 2024

Molecules

View full text Add to dashboard Cite

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Effects of propolis consumption on blood pressure, lipid profile and glycemic parameters in adults: a GRADE-assessed systematic review and dose–response meta-analysis

Bahari,

Shahraki Jazinaki,

Goudarzi

et al. 2024

Br J Nutr

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Propolis, as a by-product of honey production, has shown several beneficial effects on cardiovascular risks in past randomised controlled trials, although the findings are not conclusive. In this review, we intend to evaluate the effects of propolis consumption on cardiovascular risk factors by conducting a meta-analysis. The Web of Science, Medline and Scopus databases were comprehensively searched until September 2023. Eligible studies were identified by screening, and their data were extracted. Weighted mean differences with a 95 % CI for each outcome were estimated using the random-effects model. This meta-analysis revealed that propolis consumption led to a significant decrease in the levels of TAG (weighted mean differences (WMD): –10·44 mg/dl 95 % CI: –16·58, –4·31; P = 0·001), LDL-cholesterol (WMD: –9·31 mg/dl; 95 % CI: –13·50, –5·12 mg; P < 0·001), fasting blood glucose (WMD: –7·30 mg/dl; 95 % CI: –11·58, –3·02; P = 0·001), HbA1c (WMD: –0·32 %; 95 % CI: –0·60, –0·05; P = 0·01), insulin (WMD: –1·36 μU/ml; 95 % CI: –2·36, –0·36; P = 0·007), homeostatic model assessment for insulin resistance (WMD: –0·39; 95 % CI: –0·74, –0·03; P = 0·020) and systolic blood pressure (WMD: –2·24 mmHg 95 % CI: –4·08, –0·39; P = 0·010), compared with the control groups. Furthermore, propolis consumption had a significant increasing effect on HDL-cholesterol levels (WMD: 2·03 mg/dl; 95 % CI: 0·24, 3·83; P = 0·020). In contrast, the consumption of propolis had no significant effect on total cholesterol and diastolic blood pressure levels. This systematic review and dose–response meta-analysis suggested that propolis intake may be effective in cardiometabolic improvement in adults. Further, well-designed studies are required to confirm and elucidate all aspects of these findings.

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Effects of Iranian propolis on renal function, prooxidant-antioxidant balance, metabolic status, and quality of life in patients with chronic kidney disease: A study protocol of an ongoing randomized, double-blind, placebo-controlled clinical trial

Cited by 2 publications

References 27 publications

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

Effects of propolis consumption on blood pressure, lipid profile and glycemic parameters in adults: a GRADE-assessed systematic review and dose–response meta-analysis

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