Effects of iron glycine chelate on laying performance, antioxidant activities, serum biochemical indices, iron concentrations and transferrin mRNA expression in laying hens

Xie, Chang; Elwan, Hamada A. M.; Elnesr, Shaaban S.; Dong, Xin; Feng, Jie; Zou, Xiaoting

doi:10.1111/jpn.13061

Cited by 20 publications

(10 citation statements)

References 34 publications

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“…ALB content accounts for the largest protein fraction (40-60%), and it is synthesized in the liver [46]. Both TP and ALB contents in the blood are considered markers of liver function that reflect protein synthesis [47]. TP and ALB levels decrease in rats under ferrous sulfate-induced oxidative stress conditions [45,48].…”

Section: Discussionmentioning

confidence: 99%

High Dietary Organic Iron Supplementation Decreases Growth Performance and Induces Oxidative Stress in Broilers

Han

Xin

et al. 2022

Animals

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Although Iron (Fe) is an essential nutrient that plays a vital role in respiratory processes, excessive Fe in the diet can affect the health of broilers. We investigated the effects of diet supplemented with high levels of iron chelates with lysine and glutamic acid (Fe–LG) on the growth performance, serum biochemical parameters, antioxidant status, and duodenal mRNA expression of Fe transporters in broilers. A total of 800 1-day-old male Arbor Acres broilers were assigned to 5 groups, with 8 replicates each. Broilers were fed a corn–soybean meal basal diet or basal diets supplemented with 40, 80, 400, or 800 mg Fe/kg as Fe–LG for 6 weeks. The body weight (BW) was increased in the 80 mg Fe/kg treatment group, but decreased in the 800 mg Fe/kg treatment group on day 21. During days 1–21, compared with the control group, the supplementation of the 80 mg Fe/kg increased the average daily gain (ADG) and average daily feed intake (ADFI); however, the supplementation of the 800 mg Fe/kg group decreased the ADG and increased the FCR in broilers (p < 0.05). The heart, liver, spleen, and kidney indices were reduced in the 800 mg Fe/kg treatment group (p < 0.05). The supplementation of the 800 mg Fe/kg group increased the serum aspartate aminotransferase activity and the levels of creatinine and urea nitrogen on day 42 (p < 0.05). The broilers had considerably low liver total superoxide dismutase activity and total antioxidant capacity in the 800 mg Fe/kg treatment group (p < 0.05). Serum and liver Fe concentrations were elevated in the 400 and 800 mg Fe/kg treatment groups, but were not affected in the 40 and 80 mg Fe/kg treatment groups. The duodenal Fe transporters divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) were downregulated in the Fe–LG treatment groups (p < 0.05). We conclude that a high dietary supplement of 800 mg Fe/kg in broilers leads to detrimental health effects, causing kidney function injury and liver oxidative stress.

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Section: Discussionmentioning

confidence: 99%

High Dietary Organic Iron Supplementation Decreases Growth Performance and Induces Oxidative Stress in Broilers

Han

Xin

et al. 2022

Animals

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“…Some early studies found that the bioavailability of Fe-Gly was at least 2 times more than FeSO4 [14,21,22]. Supplementing Fe-Gly in laying hens increased LR and egg weight compared with FeSO4, while ADFI and FCR showed no differences [23]. Adding Fe-Gly in the basal diet enhanced performance of hens and decreased the abnormal egg rate in contrast to inorganic ferrous [6].…”

Section: Laying Performancementioning

confidence: 99%

“…Several studies shown that supplementing organic source of iron could improve antioxidant capacity of the body. The activities of T-SOD and Cu/Zn-SOD were raised along with the growth of additive dosage of Fe-Gly [23]. The Fe-Gly supplementation effectively increased the activities of SOD and decreased the content of MDA in serum of layers at 9 wk and 12 wk of the experiment [6].…”

Section: Antioxidant Capacitymentioning

confidence: 99%

Efficacy evaluation of novel organic iron complexes in laying hens: effects on laying performance, egg quality, egg iron content, and blood biochemical parameters

Cao¹,

Zhu²,

Zhou³

et al. 2023

Anim Biosci

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Objective: This study was conducted to determine the optimal dose of novel iron amino acid complexes (Fe-Lys-Glu) by measuring laying performance, egg quality, egg iron (Fe) concentrations, and blood biochemical parameters in laying hens.Methods: A total of 1,260 18-week-old healthy Beijing White laying hens were randomly divided into 7 groups with 12 replicates of 15 birds each. After a 2-wk acclimation to the basal diet, hens were fed diets supplemented with 0 (negative control, the analyzed innate iron content was 75.06 mg/kg), 15, 30, 45, 60, and 75 mg Fe/kg as Fe-Lys-Glu or 45 mg Fe/kg from FeSO4 (positive control) for 24 wk. Results:Results showed that compared with the negative and positive control groups, dietary supplementation with 30 to 75 mg Fe/kg from Fe-Lys-Glu significantly (linear and quadratic, p<0.05) increased the laying rate (LR) and average daily egg weight (ADEW); hens administered 45 to 75 mg Fe/kg as Fe-Lys-Glu showed a remarkable (linear, p<0.05) decrease in feed conversion ratio (FCR) . There were no significant differences among all groups in egg quality. The iron concentrations in egg yolk and serum were elevated by increasing Fe-Lys-Glu levels, and the highest iron content was found in 75 mg Fe/kg group. In addition, hens fed 45 mg Fe/kg from Fe-Lys-Glu had (linear and quadratic, p<0.05) higher yolk Fe contents than that with the same dosage of FeSO4 supplementation . The red blood cell (RBC) count and hemoglobin (HGB) content (linear and quadratic, p<0.05) increased obviously in the groups fed with 30 to 75 mg Fe/kg as Fe-Lys-Glu in comparison with the control group. Fe-Lys-Glu supplementation also (linear and quadratic, A c c e p t e d A r t i c l e 2 p<0.05) enhanced the activity of copper/zinc-superoxide dismutase (Cu/Zn-SOD) in serum, as a result, the serum malonaldehyde (MDA) content (linear and quadratic, p<0.05) decreased in hens received 60 to 75 mg Fe/kg as Fe-Lys-Glu. Conclusion:Supplementation Fe-Lys-Glu in laying hens could substitute for FeSO4 and the optimal additive levels of Fe-Lys-Glu are 45 mg Fe/kg in layers diets based on the quadratic regression analysis of LR, ADEW, RBC, and Cu/Zn-SOD.

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“…According to research, amino-chelated or proteinated sources of iron are preferable to FeSO4 as a form of iron supplementation [31,32]. Then again, other studies discovered that the inorganic and organic sources (amino acid complexes) were equivalent in terms of mineral retention and eggshell quality [33]. When Fe-Lys-Glu was given to hens at a dosage of 45 mg/kg, the yolk Fe content was higher (p <0.05) than when FeSO4 was added at the same dosage [34].…”

Section: Manganese (Mn)mentioning

confidence: 99%

The Effect of Trace Mineral Supplementations on Egg Production and Quality: A Review

Nair

Anil²,

Sivaprasad³

et al. 2022

CJAST

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This review aimed to study and discuss the effects of organic and inorganic sources of trace minerals; zinc, copper, and manganese in the diet of laying hens on egg production and quality. These trace minerals are required in producing proteins that are involved in various biochemical reactions, hormone secretion pathways, eggshell formation, antioxidative properties, immune system defence, etc. The results of different studies were not always consistent, mainly concerning the egg quality indices; however, most of the findings have shown positive effects of these trace minerals on laying hens. Recent studies have shown organic minerals are a more effective source than inorganic. The benefit of using organic sources is their lower inclusion rates due to their better absorption rate and the low output through excreta.

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Effects of iron glycine chelate on laying performance, antioxidant activities, serum biochemical indices, iron concentrations and transferrin mRNA expression in laying hens

Cited by 20 publications

References 34 publications

High Dietary Organic Iron Supplementation Decreases Growth Performance and Induces Oxidative Stress in Broilers

High Dietary Organic Iron Supplementation Decreases Growth Performance and Induces Oxidative Stress in Broilers

Efficacy evaluation of novel organic iron complexes in laying hens: effects on laying performance, egg quality, egg iron content, and blood biochemical parameters

The Effect of Trace Mineral Supplementations on Egg Production and Quality: A Review

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