Effects of iron overload on bone remodeling in pigs

Vernejoul, M. C. De; Pointillart, Alain; Golenza, C.C.; Morieux, Caroline; Bielakoff, J.; Modrowski, Dominique; Miravet, L

doi:10.1016/8756-3282(85)90365-5

Cited by 44 publications

(71 citation statements)

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“…By searching for factor(s) other than estrogen deficiency in osteoporosis, we found that both dietary iron deficiency and overload affect bone in animal studies (8,18,19,21,23,29). One recent report showed that osteoporosis patients are slightly iron deficient, having lower serum iron and higher transferrin as compared with the control group (7).…”

Section: Iron and Osteoporosismentioning

confidence: 95%

Iron and Menopause: Does Increased Iron Affect the Health of Postmenopausal Women?

Jian

Pelle

Huang

2009

Antioxidants & Redox Signaling

142

125

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Estrogen deficiency has been regarded as the main causative factor in menopausal symptoms and diseases. Here, we show that although estrogen decreases by 90%, a concurrent but inverse change occurs in iron levels during menopausal transition. For example, levels of serum ferritin are increased by two-to threefold from before menopause to after menopause. This observation has led us to hypothesize that, in addition to estrogen deficiency, increased iron as a result of menopause could be a risk factor affecting the health of postmenopausal women. Further studies on iron and menopause are clinically relevant and may provide novel therapeutic treatments.

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Section: Iron and Osteoporosismentioning

confidence: 95%

Iron and Menopause: Does Increased Iron Affect the Health of Postmenopausal Women?

Jian

Pelle

Huang

2009

Antioxidants & Redox Signaling

142

125

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“…These bone diseases display PTH hyposecretion, excessive osteoid of the bone surface, mineralization defect, and the disappearance of uorescent labels (1,5,10,32,36,37). In the present study, bone resorption progressed rapidly, but was not accompanied by any mineralization defect.…”

Section: Discussionmentioning

confidence: 99%

Iron Lactate-Induced Osteopenia in Male Sprague-Dawley Rats

et al. 2001

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Osteopenia was induced in rats fed a diet containing 50,000 ppm (5%) iron lactate for 2 or 4 weeks. Blood chemistry, urinalysis, and bone histomorphometr y of the proximal tibial metaphysis were performed. Urinary pyridinoline and deoxypyridinolin e and the osteoclast number per bone surface were selected for the measuremen t of dynamic resorption. The osteoclast surface, eroded surface, and osteoblast surface increased at both ends of the exposure periods, and bone resorption and formation both increased. The bone volume, trabecular thickness, and trabecular number decreased, and the secondary spongiosa of proximal metaphysis showed a marked bone loss. However, no mineralization defect was observed. At the end of the 2-week exposure period, biomarkers of osteoclasts and osteoblasts had increased the most, and the osteoblast surface, osteoclast surface, and osteoclast number per bone surface increased with prolonged exposure. The pathological changes of the bone lesion in iron lactate-overloade d rats were similar to those in rats of the osteoporotic model, because they consisted of changes re ecting the increase of bone resorption and formation without an osteomalacic change. However, the decline of serum parathyroid hormone (PTH) levels was different from that of the osteoporosi s model rat.We concluded iron-induced bone lesions probably differ from those of low turnover bone diseases.

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“…The pig was chosen as the experimental model, because its bone structure and bone remodeling resemble those in humans (42). weight matched and then randomly assigned to 3 groups of 12 animals: one group was given NaF orally at 2 mg NaF/kg/d (-0.91 mg F-/ kg/d), one group received ALN orally at 1 mg/kg/d, and one group served as controls and received vehicle (sucrose 200 mg/ml, sodium benzoate 1 mg/ml, and corn starch 80 mg/ml).…”

Section: Introductionmentioning

confidence: 99%

Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. A one-year study.

Lafage

Balena²,

Battle³

et al. 1995

J. Clin. Invest.

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Fluoride stimulates trabecular bone formation, whereas bisphosphonates reduce bone resorption and turnover. Fracture prevention has not been convincingly demonstrated for either treatment so far. We compared the effects of 1-yr treatment of 9-mo-old minipigs with sodium fluoride (NaF, 2 mg/kg/d p.o.) or alendronate (ALN, 4 amino-l-hydroxy-on the biomechanical and histomorphometric properties of pig bones. As expected, NaF increased and ALN decreased bone turnover, but in these normal animals neither changed mean bone volume. NaF reduced the strength of cancerous bone from the LA vertebra, relative to control animals, and the stiffness (resistance to deformation) of the femora, relative to the ALN group. In the ALN-treated animals, there was a strong positive correlation between bone strength and L5 cancerous bone volume, but no such correlation was observed in the NaF group. Furthermore, the modulus (resistance to deformation of the tissue) was inversely related to NaF content and there was a relative decrease in bone strength above 0.25 mg NaF/g bone. Moreover, within the range of changes measured in this study, there was an inverse correlation between bone turnover, estimated as the percentage of osteoid surface, and modulus. These findings have relevant implications regarding the use of these agents for osteoporosis therapy. (J. Clin. Invest. 1995. 95:2127-2133

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Effects of iron overload on bone remodeling in pigs

Cited by 44 publications

References 1 publication

Iron and Menopause: Does Increased Iron Affect the Health of Postmenopausal Women?

Iron and Menopause: Does Increased Iron Affect the Health of Postmenopausal Women?

Iron Lactate-Induced Osteopenia in Male Sprague-Dawley Rats

Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. A one-year study.

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