Effects of Irrigation on Mitomycin-C Concentration and Pharmacokinetics Parameters in Rabbit’s Eyes

Machado, Ceg; SusannaJr., R.

doi:10.1007/978-3-642-57056-8_33

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…MMC is known to be present on the ocular surface and absorbed into the sclera and aqueous humor despite copious irrigation. 33 34 Ciliary body toxicity caused by MMC might play a role in the higher incidence of hypotony 35 36 as compared to the subconjunctival injection group. However, this was not observed in the other two studies.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Surgical Outcomes of Sponge Application Versus Subconjunctival Injection of Mitomycin-C During Combined Phacoemulsification and Trabeculectomy Surgery in Asian Eyes

Chiew

Guo

Ang

et al. 2021

Journal of Current Ophthalmology

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Purpose: To compare the outcomes of combined phacoemulsification–trabeculectomy surgery with intraoperative sponge-applied versus subconjunctival injection of mitomycin-C (MMC) in Asian eyes. Methods: This was a retrospective review of 95 eyes that consecutively underwent combined phacoemulsification–trabeculectomy surgery in a tertiary eye center in Singapore from January 2013 to June 2014. Data collected included intraocular pressure (IOP), best corrected visual acuity, and number of glaucoma medications. Outcome measures included postoperative IOP and complications at various timepoints up to 12 months after surgery. Results: Twenty eyes (21.1%) received 0.2 mg/ml subconjunctival MMC injection (“Group 1”) and 75 (78.9%) received 0.4 mg/ml sponge-applied MMC (“Group 2”). There was no difference between groups in demographics, IOP, and number of glaucoma medications preoperatively. There was a reduction in IOP at postoperative month (POM) 1, 6, and 12 in both the groups (POM12: Group 1, −2.8 ± 5.36 mmHg, P < 0.001; Group 2, −5.8 ± 6.29 mmHg, P = 0.054). At POM1, Group 2 showed a trend toward greater IOP reduction (−5.89 ± 7.67 mmHg vs. −1.55 ± 5.68 mmHg, P = 0.061). However, at both POM6 and POM12, there was no statistically significant difference in IOP reduction between the two groups. At POM12, complete success, defined as achieving an IOP of between 6 and 15 mmHg without the use of antiglaucoma medications, was achieved in 11 (55%) eyes in Group 1 and 48 (64%) in Group 2 ( P = 0.9). There was a lower rate of postoperative hypotony in the Group 1 (0%) compared to Group 2 (8%) ( P = 0.34). Conclusion: Combined phacoemulsification–trabeculectomy with subconjunctival MMC injection has comparable outcomes to that with sponge-applied MMC, with a similar reduction in IOP at 1, 6, and 12 months postoperatively and a lower postoperative complication rate.

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Section: Discussionmentioning

confidence: 99%

Comparison of Surgical Outcomes of Sponge Application Versus Subconjunctival Injection of Mitomycin-C During Combined Phacoemulsification and Trabeculectomy Surgery in Asian Eyes

Chiew

Guo

Ang

et al. 2021

Journal of Current Ophthalmology

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“…A MMC aplicada em superfícies oculares externas como a esclera, pode no entanto penetrar no olho e atingir o humor aquoso (2)(3)(4)(5)(6)(7) . Estudos mostraram que após aplicação da MMC na esclera foram observadas lesões tóxicas no corpo ciliar (8)(9)(10)(11)(12)(13)(14)(15) .…”

Section: Resumo Introduçãounclassified

Toxicidade da mitomicina C ao endotélio da córnea de coelhos

Silva¹,

Gregório²

2009

Arq. Bras. Oftalmol.

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Effects of Irrigation on Mitomycin-C Concentration and Pharmacokinetics Parameters in Rabbit’s Eyes

Cited by 2 publications

References 4 publications

Comparison of Surgical Outcomes of Sponge Application Versus Subconjunctival Injection of Mitomycin-C During Combined Phacoemulsification and Trabeculectomy Surgery in Asian Eyes

Comparison of Surgical Outcomes of Sponge Application Versus Subconjunctival Injection of Mitomycin-C During Combined Phacoemulsification and Trabeculectomy Surgery in Asian Eyes

Toxicidade da mitomicina C ao endotélio da córnea de coelhos

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