1987
DOI: 10.1097/00005344-198711000-00012
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Effects of Ischemia on the Canine Myocardial β-Adrenoceptor-Linked Adenylate Cyclase System

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Cited by 24 publications
(9 citation statements)
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“…The hypothesis which suggests that investigators [100,102]; however, others have failed to vitamin E may act as a second line of defense (Fig. 1), confirm these findings [99,103]. The increase in b -adren-1 may explain in part these conflicting results.…”
Section: Catalase and Superoxide Dismutase In Ischemia-mentioning
confidence: 87%
“…The hypothesis which suggests that investigators [100,102]; however, others have failed to vitamin E may act as a second line of defense (Fig. 1), confirm these findings [99,103]. The increase in b -adren-1 may explain in part these conflicting results.…”
Section: Catalase and Superoxide Dismutase In Ischemia-mentioning
confidence: 87%
“…Variables include the influences of sympathetic cardiac stimulation, elevated circulating catecholamine levels, a heterogenous cell population, and the lack of methods for producing a uniform ischemic insult. The results ofstudies using purified myocardial membranes prepared from in vivo ischemic myocardium to investigate the consequences ofacute ischemia or hypoxia on the ,BAR-adenylate cyclase system are inconsistent (11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Recent observations in our laboratory suggest that variations in the preparation of purified membranes may, in part, explain these discrepancies (21).…”
Section: Introductionmentioning
confidence: 99%
“…The absence of universal LV dysfunction despite the chronic adrenergic excess in all pheo patients is also intriguing. Persistent elevation of plasma catecholamine levels might induce adrenergic receptor desensitization via mechanisms that include receptor modulation and uncoupling from down-stream effectors[20,21]. Genetic susceptibility mediated through adrenergic receptor[22,23] and G protein coupled receptor kinase polymorphisms (GRK5)[24] may also account for differences in predisposition to cardiac dysfunction in pheo and TC related LV dysfunction despite similar catecholamine elevations.…”
Section: Discussionmentioning
confidence: 99%