Effects of Isoflavone-Rich NADES Extract of Pueraria lobata Roots and Astaxanthin-Rich Phaffia rhodozyma Extract on Prostate Carcinogenesis in Rats

Семенов, А. Л.; Tyndyk, Margarita L.; Von, Julia D.; Ermakova, Elena D; Dorofeeva, A. A.; Tumanyan, Irina A; Radetskaya, Ekaterina; Yurova, Maria N.; Zherebker, Alexander; Gorbunov, Alexander Yu.; Fedoros, Elena I.; Panchenko, Andrey; Anisimov, Vladimir N.

doi:10.3390/plants12030564

Cited by 5 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Different NADESs/DESs were used to improve the bioavailability and/or biocompatibility of different compounds [36,[76][77][78][79][80]. Xiao et al developed a novel hydrogel system incorporating an amino acid-based DES.…”

Section: Animal Modelsmentioning

confidence: 99%

Has the Toxicity of Therapeutic Deep Eutectic Systems Been Assessed?

et al. 2023

View full text Add to dashboard Cite

Therapeutic Deep Eutectic Systems (THEDESs) are a mixture of components, including an active pharmaceutical ingredient, that have recently emerged because of their interesting properties for drug therapies. In general, they have been recognized to increase the solubility and permeability of some drugs, and consequently, their bioavailability. Moreover, they have also been used for novel formulations of pharmaceuticals. Despite the potential benefits of THEDESs, concerns about their safety and toxicity remain. In this review, we summarize previous studies that have investigated the toxicity of THEDESs. These studies evaluate the toxicity of THEDESs using various methods, including cell cultures, animal models, and human trials. The results of previous findings suggest that THEDESs are generally well-tolerated and have low toxicity. However, further research is needed to fully understand the long-term effects of these systems on human health and to identify any potential adverse effects.

show abstract

Section: Animal Modelsmentioning

confidence: 99%

Has the Toxicity of Therapeutic Deep Eutectic Systems Been Assessed?

et al. 2023

View full text Add to dashboard Cite

show abstract

“…It is an isoflavone compound extracted from pueraria root, furnished with many pharmacological effects such as anti-inflammation, anti-cancer, anti-oxidation and anti-ischemia reperfusion injury [ 10 – 13 ]. Previous studies have shown the positive anti-cancer effects of puerarin in a variety of cancers, including prostate cancer[ 14 ], lung cancer[ 15 ], and oral squamous cell carcinoma [ 16 ]. In addition, its protective effect on nervous system diseases by activating PI3K/Akt signaling pathway has also been confirmed, which also delays degenerative diseases of the nervous system [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Effects and mechanisms of puerarin against neuroblastoma: insights from bioinformatics and in vitro experiments

Sui,

Liu,

Zou

et al. 2024

BMC Complement Med Ther

View full text Add to dashboard Cite

Background Neuroblastoma, a prevalent solid tumor in children, often manifests with hidden onset sites, rapid growth, and high metastatic potential. The prognosis for children with high-risk neuroblastoma remains poor, highlighting the urgent need for novel prognostic models and therapeutic avenues. In recent years, puerarin, as a kind of small molecule drug extracted from Chinese medicine Pueraria lobata, has demonstrated significant anticancer effects on various cancer cell types. In this study, through bioinformatics analysis and in vitro experiments, the potential and mechanism of puerarin in the treatment of neuroblastoma were investigated, and a prognostic model was established. Methods A total of 9 drug-disease related targets were observed by constructing a database of drug targets and disease genes. Besides, GO and KEGG enrichment analysis was performed to explore the potential mechanism of its therapeutic effect. To construct the prognostic model, risk regression analysis and LASSO analysis were carried out for validation. Finally, the prognostic genes were identified. Parachute test and immunofluorescence staining were performed to verify the potential mechanism of puerarin in neuroblastoma treatment. Results Three prognostic genes, i.e., BIRC5, TIMP2 and CASP9, were identified. In vitro studies verified puerarin's impact on BIRC5, TIMP2, and CASP9 expression, inhibiting proliferation in neuroblastoma SH-SY5Y cells. Puerarin disrupts the cytoskeleton, boosts gap junctional communication, curtailing invasion and migration, and induces mitochondrial damage in SH-SY5Y cells. Conclusions Based on network pharmacology and bioinformatics analysis, combined with in vitro experimental verification, puerarin was hereby observed to enhance GJIC in neuroblastoma, destroy cytoskeleton and thus inhibit cell invasion and migration, cause mitochondrial damage of tumor cells, and inhibit cell proliferation. Overall, puerarin, as a natural medicinal compound, does hold potential as a novel therapy for neuroblastoma.

show abstract

“…In a previous research study, the impact of extracts was analyzed using animal models. A rat model of prostate cancer was used to study the effects of an extract of Pueraria lobata roots rich in isoflavones and Phaffia rhodozyma extract rich in astaxanthin [9].…”

mentioning

confidence: 99%