Effects of isoflurane on echocardiographic parameters in healthy dogs

Sousa, Marlos Gonçalves; Carareto, Roberta; De-Nardi, Andrigo B.; Brito, Fábio Luiz da Cunha; Nunes, Newton; Camacho, Aparecido Antônio

doi:10.1111/j.1467-2995.2007.00370.x

Cited by 32 publications

(35 citation statements)

References 19 publications

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“…Left EDVs were higher, ESVs were lower; left ventricular stroke volume and EFs were higher using echocardiography in the awake animals compared to any of the anesthesia modality combinations, even though there was overlap. These findings are consistent with those found in previous studies in isoflurane‐anesthetized dogs . A recent study compared echocardiographic measurement of the left ventricular volume using the Teicholz and modified Simpson method to left ventricular volumes acquired using dual‐source CT and applying the Simpson method in seven propofol/isoflourane‐anesthetized dogs using medetomedine as premedication.…”

Section: Discussionsupporting

confidence: 89%

“…The IVSs measurement was larger when evaluated using echocardiography in the awake dogs, possibly indicating higher contractility in the awake compared to anesthetized dog as shown in previous reports in isoflurane‐anesthetized dogs; this effect was present but weaker for LVPWs. Similarly, the fractional shortening was greater and LVIDs was lower in the awake dogs compared to either of our anesthesia protocols, most likely due to the background of isoflurane in all dogs . The aortic and pulmonary artery diameter was larger in the awake vs. anesthetized patients.…”

Section: Discussionsupporting

confidence: 55%

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Quantitative Planar and Volumetric Cardiac Measurements Using 64 MDCT and 3t Mri vs. Standard 2d and M‐mode Echocardiography: Does Anesthetic Protocol Matter?

Drees

Johnson

Stepien

et al. 2015

Vet Radiology Ultrasound

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Cross-sectional imaging of the heart utilizing computed tomography (CT) and magnetic resonance imaging (MRI) has been shown to be superior for the evaluation of cardiac morphology and systolic function in humans compared to echocardiography. The purpose of this prospective study was to test the effects of two different anesthetic protocols on cardiac measurements in 10 healthy beagle dogs using 64-multidetector row computed tomographic angiography (64-MDCTA), 3T magnetic resonance (MRI) and standard awake echocardiography. Both anesthetic protocols used propofol for induction and isoflourane for anesthetic maintenance. In addition, protocol A used midazolam/fentanyl and protocol B used dexmedetomedine as premedication and constant rate infusion during the procedure. Significant elevations in systolic and mean blood pressure were present when using protocol B. There was overall good agreement between the variables of cardiac size and systolic function generated from the MDCTA and MRI exams and no significant difference was found when comparing the variables acquired using either anesthetic protocol within each modality. Systolic function variables generated using 64-MDCTA and 3T MRI were only able to predict the left ventricular end diastolic volume as measured during awake echocardiogram when using protocol B and 64-MDCTA. For all other systolic function variables, prediction of awake echocardiographic results was not possible (P = 1). Planar variables acquired using MDCTA or MRI did not allow prediction of the corresponding measurements generated using echocardiography in the awake patients (P=1). Future studies are needed to validate this approach in a more varied population and clinically affected dogs.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 55%

Quantitative Planar and Volumetric Cardiac Measurements Using 64 MDCT and 3t Mri vs. Standard 2d and M‐mode Echocardiography: Does Anesthetic Protocol Matter?

Drees

Johnson

Stepien

et al. 2015

Vet Radiology Ultrasound

View full text Add to dashboard Cite

show abstract

“…Although some studies have demonstrated that it may be dependent on heart rate (Poulsen et al 2000), previous studies in healthy dogs and in human beings also documented an absence of correlation with such parameter (Sousa et al 2007). More studies are needed to better clarify the dependency of these two measurements, as the influence of heart rate in the Tei index remains controversial and could potentially preclude its use in dogs presenting tachyarrhythmias.…”

Section: Discussionmentioning

confidence: 94%

“…In dogs with myxomatous mitral valve disease, it increased with the progression of clinical signs, apparently because of the shortening of the ejection time resulting from the reduction in forward stroke volume (Teshima et al 2007). In a study in which 16 healthy adult dogs undergoing isoflurane anesthesia were enrolled, the index demonstrated to be a heart rate-independent predictor of impaired global myocardial function (Sousa et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Tei index of myocardial performance in conscious healthy Beagles

et al. 2016

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ABSTRACT. The Tei index of myocardial performance is a noninvasive echocardiographic parameter that combines systolic and diastolic time intervals to assess global cardiac performance. It was demonstrated to be a reliable indicator of myocardial dysfunction in dogs with varying clinical conditions. Because only a few studies focused on the measurement of the index in healthy dogs, this cross-sectional study was conceived to investigate how it performs in a large population of clinically healthy Beagle dogs. Our results showed no correlation between the index and body weight, heart rate, and several standard echocardiographic measures which are estimates of preload and afterload. There was no difference between de index calculated for males or females. Also, results indicated strong intra-observer and inter-observer correlations. In conclusion, the Tei index was shown to perform independently of loading conditions, besides being a straightforward and easily reproducible parameter.Key words: echocardiography, cardiac function, Doppler, dog. RESUMEN.El índice de rendimiento miocárdico es un parámetro ecocardiográfico no invasivo que combina intérvalos de tiempo sistólico y diastólico para evaluar el rendimiento cardiaco total. Se ha demostrado que es un indicador fiable de disfunción miocárdica en perros con diferentes condiciones clínicas. Debido a que pocos estudios se centraron en la medición de este índice en perros sanos, este estudio transversal fue concebido para investigar este rendimiento en una gran población de perros Beagle clínicamente sanos. Nuestros resultados no muestran correlación entre el índice y el peso corporal, la frecuencia cardiaca, y varias medidas ecocardiográficas que son estimaciones estándar de precarga y poscarga. No hubo diferencia entre machos y hembras para el índice calculado. Además, los resultados indicaron notorias correlaciones intraobservador e interobservador. En conclusión, el índice de Tei se mostró como un parámetro independiente de las condiciones de la carga, que además de ser fácil de calcular también es un parámetro de fácil reproducción.

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“…Entre os agentes halogenados, observa-se, proporcionalmente, um índice mais elevado de mortalidade para o isofluorano do que para o halotano. Entretanto, o isoflurano apresenta menor tempo de indução e recuperação, menor depressão cardiorrespiratória, sendo marcadamente mais seguro em relação ao halotano para manutenção da função cardiovascular, apesar de estudos ecocardiográficos demonstrarem que 1 CAM de isofluorano é capaz de produzir efeito depressor significante do miocárdio (SOUSA et al, 2008). Sugerese que este índice de mortalidade maior para fármacos comprovadamente mais seguros esteja relacionado a uma maior aplicação desses agentes em pacientes com comprometimento sistêmico (ASA III a V) e hemodinamicamente comprometidos, conforme descrito por CARARETO et al (2005), em um estudo em que um maior índice de mortalidade foi observado com a utilização do sevoflurano.…”

Section: Resultsunclassified

Índice de mortalidade durante procedimentos anestésicos: estudo retrospectivo (1996-2006)

2009

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Índice de mortalidade durante procedimentos anestésicos:estudo retrospectivo (1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006) Mortality rate during anesthesia: retrospective study (1996-2006) RESUMO (1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006) O objetivo deste estudo é reportar a incidência de óbitos anestésico-cirúrgicos durante um período de 11 anos

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Effects of isoflurane on echocardiographic parameters in healthy dogs

Cited by 32 publications

References 19 publications

Quantitative Planar and Volumetric Cardiac Measurements Using 64 MDCT and 3t Mri vs. Standard 2d and M‐mode Echocardiography: Does Anesthetic Protocol Matter?

Quantitative Planar and Volumetric Cardiac Measurements Using 64 MDCT and 3t Mri vs. Standard 2d and M‐mode Echocardiography: Does Anesthetic Protocol Matter?

Tei index of myocardial performance in conscious healthy Beagles

Índice de mortalidade durante procedimentos anestésicos: estudo retrospectivo (1996-2006)

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