Effects of Isoflurane, Sevoflurane, and Halothane on Myofilament Ca2+Sensitivity and Sarcoplasmic Reticulum Ca2+Release in Rat Ventricular Myocytes

Abstract

Depressed myofilament Ca2+ sensitivity contributes to the negative inotropic effects of isoflurane and halothane but not sevoflurane. The decrease in the Ca2+ transient is either responsible for or contributory to the negative inotropic effects of all three anesthetics and is either primarily the result of a decrease in fractional release (isoflurane and sevoflurane) or primarily the result of a decrease in SR Ca2+ content (halothane).

Reversal of Isoflurane-Induced Depression of Myocardial Contraction by Nitroxyl via Myofilament Sensitization to Ca2+

“…This point is proven by the lack of change in the amplitudes of intracellular Ca 2ϩ transients (Hanley and Loiselle, 1998;Bartunek and Housmans, 2000;Davies et al, 2000;Graham et al, 2005). This clearly hints at the possibility that ISO directly decreases myofilament Ca 2ϩ responsiveness.…”

“…At the cellular level, altered cardiac excitation-contraction coupling has been identified as a major vehicle of impaired cardiac performance. In fact, inhalational anesthetics have been shown to decrease sarcolemmal L-type Ca 2ϩ channel function (Terrar and Victory, 1988), decrease sarcoplasmic reticular Ca 2ϩ storage (Davies et al, 2000), Ca 2ϩ release (Jiang and Julian, 1998), and decrease myofilament Ca 2ϩ sensitivity (Bosnjak et al, 1992;Davies et al, 2000). More importantly, it appears that the impact of inhalational agents on myocardium is agent-and dose-dependent, with decreasing Ca 2ϩ availability being viewed as the major mode of action based on previous studies (Rusy and Komai, 1987;Housmans and Murat, 1988;Housmans et al, 2000).…”

Effects of anesthesia on conventional and speckle tracking echocardiographic parameters in a mouse model of pressure overload

“…Following a reduction in HR, the preload and ejection period increased, which led to an increase in SV and strain. However, under DA conditions, the increased administration of ISF reversed this trend by significantly reducing cardiac contraction (22,23). Due to the abnormal contraction observed in mice under DA conditions, the SV was considerably suppressed, which resulted in a reduction in strain.…”

Coronary Artery Spasm Discovered in Thorough Examination of Perioperative VT in a 26-year-old Japanese Male.

“…However, the mechanism by which volatile anesthetics decrease the threshold for catecholamine-induced arrhythmia is unknown. Volatile anesthetics decrease intracellular Ca 2+ transient 3) via an inhibition of the L-type Ca 2+ current 4) which tends to decrease Ca 2+ overload. Shortening of the action potential duration by volatile anesthetics 4) one reason for the increase in catecholamine-induced arrhythmia during anesthesia.…”