Effects of Isolated Vitamin B6 Supplementation on Oxidative Stress and Heart Function Parameters in Experimental Hyperhomocysteinemia

Mendes, Roberta Hack; Candido, Georgia Orsi; Mostarda, Cristiano Teixeira; Sirvente, Raquel; D’Almeida, Vânia; Ribeiro, Maria Flávia Marques; Araújo, Alex Sander da Rosa; Salemi, Vera Maria Cury; Rigatto, Katya; Irigoyen, Maria Cláudia

doi:10.4322/2357-9730.70767

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…Among these factors, the effects of malnutrition on immunity have been widely investigated on fish growth (Dawood et al, 2019;Ming et al, 2013;Wei et al, 2014). Pyridoxine (PN) has been known as an essential nutritional factor for animals, which plays important roles in many physiological and biochemical processes, including growth, amino acid metabolism, gluconeogenesis, lipid metabolism, immune response and the oxidative stress (Cabrini et al, 2010;Mendes et al, 2017;Qian, Shen, Zhang, & Jing, 2017). However, PN cannot be synthesized by fish and should be supplied via dietary intake (Wang, Li, Zhang, Xu, & Liu, 2013).…”

Section: Introductionmentioning

confidence: 99%

The antioxidant status, apoptosis, intercellular integrity and immune function of grass carp (Ctenopharyngodon idella) head kidney and spleen fed different levels of pyridoxine

et al. 2019

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This study was carried out to investigate the effects of dietary pyridoxine (PN) on the antioxidant status, apoptosis, intercellular integrity and immune function of head kidney and spleen in young grass carp (Ctenopharyngodon idella). Results showed that compared with the optimal PN level, (a) PN deficiency decreased antioxidant enzyme activities and down-regulated the mRNA levels of antioxidant enzymes, NF-E2related factor 2 (Nrf2), myeloid cell leukaemia-1 (Mcl-1) and tight junction proteins, whereas it increased the contents of reactive oxygen species (ROS), malondialdehyde (MDA) and protein carbonyl (PC), and up-regulated the mRNA levels of cysteinyl aspartic acid-protease (caspase), Fas ligand (FasL), p38 mitogen-activated protein kinase (p38MAPK) and myosin light chain kinase (MLCK) in the head kidney and spleen of fish (p < .05). (b) PN deficiency decreased lysozyme (LZ) and acid phosphatase (ACP) activities, and complement contents, and down-regulated the mRNA levels of antibacterial peptides, anti-inflammatory cytokines, inhibitor of κBα (IκBα) and target of rapamycin (TOR), whereas it up-regulated the mRNA levels of pro-inflammatory cytokines and nuclear factor kappa B p65 (NF-κBp65) in the head kidney and spleen of fish (p < .05). (c) Dietary PN requirements of grass carp based on the malondialdehyde content and lysozyme activity were estimated as 4.97 and 4.99 mg/kg diet, respectively. K E Y W O R D S Ctenopharyngodon idella, immune function, immune organ, pyridoxine deficiency, structural integrity S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article: Jiang W-D, Zheng X, Feng L, et al. The antioxidant status, apoptosis, intercellular integrity and immune function of grass carp (Ctenopharyngodon idella) head kidney and spleen fed different levels of pyridoxine. Aquacult

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Section: Introductionmentioning

confidence: 99%

The antioxidant status, apoptosis, intercellular integrity and immune function of grass carp (Ctenopharyngodon idella) head kidney and spleen fed different levels of pyridoxine

et al. 2019

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“…Preclinical studies showed that vitamin B6 supplementation could lead to a decrease in Hcy concentration and reduction of oxidative stress, and have a beneficial effect on markers of cardiac function [119].…”

Section: Oxidative Stress In Animal Models Of MI and Hf-the Importanc...mentioning

confidence: 99%

Homocysteine, Vitamins B6 and Folic Acid in Experimental Models of Myocardial Infarction and Heart Failure—How Strong Is That Link?

et al. 2022

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Cardiovascular diseases are the leading cause of death and the main cause of disability. In the last decade, homocysteine has been found to be a risk factor or a marker for cardiovascular diseases, including myocardial infarction (MI) and heart failure (HF). There are indications that vitamin B6 plays a significant role in the process of transsulfuration in homocysteine metabolism, specifically, in a part of the reaction in which homocysteine transfers a sulfhydryl group to serine to form α-ketobutyrate and cysteine. Therefore, an elevated homocysteine concentration (hyperhomocysteinemia) could be a consequence of vitamin B6 and/or folate deficiency. Hyperhomocysteinemia in turn could damage the endothelium and the blood vessel wall and induce worsening of atherosclerotic process, having a negative impact on the mechanisms underlying MI and HF, such as oxidative stress, inflammation, and altered function of gasotransmitters. Given the importance of the vitamin B6 in homocysteine metabolism, in this paper, we review its role in reducing oxidative stress and inflammation, influencing the functions of gasotransmitters, and improving vasodilatation and coronary flow in animal models of MI and HF.

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Is Homocysteine a Biomarker of Environmental Health Risk and Epigenetic-DNA Methylation: Links to Cardiovascular Pathogenesis and B Vitamins

Djuric,

Todorović,

Bajić

et al. 2024

Advances in Biochemistry in Health and Disease

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Effects of Isolated Vitamin B6 Supplementation on Oxidative Stress and Heart Function Parameters in Experimental Hyperhomocysteinemia

Abstract: Introduction: The purpose of this study was to investigate the effects of isolated vitamin B 6 (VB 6 ) supplementation on experimental hyperhomocysteinemia (Hhe) induced by homocysteine thiolactone (HcyT).

Cited by 3 publications

References 38 publications

The antioxidant status, apoptosis, intercellular integrity and immune function of grass carp (Ctenopharyngodon idella) head kidney and spleen fed different levels of pyridoxine

The antioxidant status, apoptosis, intercellular integrity and immune function of grass carp (Ctenopharyngodon idella) head kidney and spleen fed different levels of pyridoxine

Homocysteine, Vitamins B6 and Folic Acid in Experimental Models of Myocardial Infarction and Heart Failure—How Strong Is That Link?

Is Homocysteine a Biomarker of Environmental Health Risk and Epigenetic-DNA Methylation: Links to Cardiovascular Pathogenesis and B Vitamins

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