Effects of isoproterenol and propranolol on the inducibility and frequency of ventricular fibrillation in patients with Brugada syndrome

Abstract

ISP suppressed induction of VF and the increase of DF with time. PRO aggravated VF and accelerated DF.

Indication of ICD in Brugada syndrome

“…Further, a higher dominant frequency (DF) of the VF was noted in high‐risk patients with Brugada syndrome [44]. The pharmacological change in the DF during VF in patients with Brugada syndrome was consistent with findings indicated in previous reports [45]. These findings might indicate that investigating the characteristics involved in inducing VF may have potential as a predictive value for sudden cardiac death in asymptomatic Brugada syndrome.…”

Circulating heart-type fatty acid-binding protein levels predict ventricular fibrillation in Brugada syndrome

“…Third, we did not evaluate pathological myocardial damage by biopsy, structural changes by cardiac magnetic resonance imaging, or gene mutations [28]. The association between myocardial damage and b-adrenergic agonists was also not evaluated in the present study [29].…”

Effects of isoproterenol infusion on the ST segment and r′ of the QRS complex in the right precordial leads of the Brugada-type electrocardiogram pattern

“…Namely, in a 67-year-old woman with the Brugadatype ECG, ISP infusion reduced the ST-T elevation and unexpectedly demonstrated a lack of late r wave in lead V 1 . Subsequent reports, including the report by Omiya et al, confirmed a similar ECG-ST segment response to ISP infusion [1,4]. Also, association between the fluctuation of the ECG-ST level and the changes in r of QRS complex in the right precordial leads is described in patients with Brugada-type ECG [4].…”

“…I read with interest the report by Omiya et al on the effects of isoproterenol (ISP) and propranolol on the inducibility of malignant arrhythmia in patients with Brugada syndrome [1]. I would like to call attention to my previous publications on this subject.…”