Effects of isosorbide dinitrate on electrocardiography, hemodynamics, and ventilation in patients with exercise‐induced elevation of pulmonary artery wedge pressure

Lh, Jørgensen; Thaulow, Erik; He, Refsum

doi:10.1002/clc.4960221006

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…Several studies have demonstrated a close association between exertional hyperpnoea and cardiac dysfunction ( Clark & Coats, 1994; Sullivan & Hawthorne, 1995; Jørgensen et al ., 1997 ; Jørgensen et al ., 1999 ). Accordingly, the fact that part of the excessive ventilatory response to exercise observed pre‐operatively persisted after elimination of the peripheral vascular insufficiency, was probably because the patients showed distinct evidence of left heart disease, with marked left ventricular dysfunction during moderate exercise.…”

Section: Discussionmentioning

confidence: 99%

Delayed respiratory response to exercise of short duration in patients with severe intermittent claudication due to bilateral atherosclerotic vascular disease: normalization after aorto‐bifemoral bypass operation

Refsum

1999

Clinical Physiology

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To investigate the respiratory response to exercise in patients with severe intermittent claudication, eight male patients, aged 57 years (range 43-73), with bilateral multi-segment atherosclerotic vascular disease, median maximum walking distance 50 m (range 20-200) and ankle-to-arm pressure index 0.4 (range 0.3-0.6), were studied before and after aorto-bifemoral bypass operation. Ventilation, CO2 output and O2 intake were recorded in the sitting position during 20 min of rest, 1 min of leg exercise on a bicycle ergometer [4.9 kJ (500 kpm)], and 20 min of recovery and rest. Before operation, maximal ventilation and CO2 output per minute were observed 2-4 min after cessation of work, while afterwards peak values were found during the work or the first minute of recovery. Pre-operatively, the extra ventilation and CO2 output during the work and recovery period and the recovery times of the ventilation and CO2 output per minute were markedly increased. Afterwards these values were clearly reduced towards normal. It is concluded that patients with severe intermittent claudication show a characteristic delay and prolonged rise in the respiratory response to exercise of short duration, which closely corresponds to the previously described pattern of outflow of hypoxia-generated metabolites from the exercising muscles. The pattern of respiratory response after operation reflects the fact that these patients also suffer from atherosclerotic heart dysfunction.

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Section: Discussionmentioning

confidence: 99%

Delayed respiratory response to exercise of short duration in patients with severe intermittent claudication due to bilateral atherosclerotic vascular disease: normalization after aorto‐bifemoral bypass operation

Refsum

1999

Clinical Physiology

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The effects of bolus isosorbide dinitrate on pulmonary hypertension with cardiopulmonary comorbidities

Kashimura,

Tsuchiya,

Sawaguchi

et al. 2024

Heart Vessels

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Effects of isosorbide dinitrate on electrocardiography, hemodynamics, and ventilation in patients with exercise‐induced elevation of pulmonary artery wedge pressure

Abstract: Isosorbide dinitrate treatment markedly improved exercise-induced left heart dysfunction, whereas excessive ventilatory response was unaffected, even after 3 h. Thus, measurements of the exercise hyperpnea did not properly reflect effective reduction of myocardial ischemia.

Cited by 2 publications

References 39 publications

Delayed respiratory response to exercise of short duration in patients with severe intermittent claudication due to bilateral atherosclerotic vascular disease: normalization after aorto‐bifemoral bypass operation

Delayed respiratory response to exercise of short duration in patients with severe intermittent claudication due to bilateral atherosclerotic vascular disease: normalization after aorto‐bifemoral bypass operation

The effects of bolus isosorbide dinitrate on pulmonary hypertension with cardiopulmonary comorbidities

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