Growth of the single-fluid single-mode Rayleigh-Taylor instability (RTI) is revisited in 2D and 3D using fully compressible high-resolution simulations. We conduct a systematic analysis of the effects of perturbation Reynolds number (Re p ) and Atwood number (A) on RTI's late-time growth. Contrary to the common belief that single-mode RTI reaches a terminal bubble velocity, we show that the bubble re-accelerates when Re p is sufficiently large, consistent with [Ramaparabhu et al. 2006, Wei andLivescu 2012]. However, unlike in [Ramaparabhu et al. 2006], we find that for a sufficiently high Re p , the bubble's late-time acceleration is persistent and does not vanish. Analysis of vorticity dynamics shows a clear correlation between vortices inside the bubble and re-acceleration. Due to symmetry around the bubble and spike (vertical) axes, the self-propagation velocity of vortices points in the vertical direction. If viscosity is sufficiently small, the vortices persist long enough to enter the bubble tip and accelerate the bubble [Wei and Livescu 2012]. A similar effect has also been observed in ablative RTI [Betti and Sanz 2006]. As the spike growth increases relative to that of the bubble at higher A, vorticity production shifts downward, away from the centerline and toward the spike tip. We modify the Betti-Sanz model for bubble velocity by introducing a vorticity efficiency factor η = 0.45 to accurately account for re-acceleration caused by vorticity in the bubble tip. It had been previously suggested that vorticity generation and the associated bubble re-acceleration are suppressed at high A. However, we present evidence that if the large Re p limit is taken first, bubble re-acceleration is still possible. Our results also show that re-acceleration is much easier to occur in 3D than 2D, requiring smaller Re p thresholds.