Effects of Itopride Hydrochloride on Plasma Gut-Regulatory Peptide and Stress-Related Hormone Levels in Healthy Human Subjects

Katagiri, Fumihiko; Shiga, Toru; Inoue, Shintaro; Sato, Yuhki; Takeyama, Masaharu

doi:10.1159/000093485

Cited by 24 publications

(12 citation statements)

References 61 publications

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“…Both positron emission tomography studies and gastric barostat studies showed a decreased postprandial volume of the proximal stomach in healthy volunteers after itopride pre‐treatment 15, 16 . Finally, an effect of itopride, which is likely to cross the blood–brain barrier, 17 on integration of TLESRs in the brainstem cannot be excluded, but is difficult to study in man.…”

Section: Discussionmentioning

confidence: 99%

The effects of itopride on oesophageal motility and lower oesophageal sphincter function in man

Scarpellini¹,

Vos²,

Blondeau³

et al. 2010

Aliment Pharmacol Ther

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Section: Discussionmentioning

confidence: 99%

The effects of itopride on oesophageal motility and lower oesophageal sphincter function in man

Scarpellini¹,

Vos²,

Blondeau³

et al. 2010

Aliment Pharmacol Ther

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“…In a study by Russo et al, comparing gut peptide levels between 42 PDS and 12 EPS patients, somatostatin levels tended to be lower in PDS compared to EPS but this did not reach statistical significance (34). Itopride, a prokinetic agent with mixed dopamine-2 receptor and cholinesterase inhibitory actions, was reported to acutely increase somatostatin plasma levels (35). The somatostatin analog octreotide was reported to slow gastric emptying, enhance fasting gastric volumes and suppress mealinduced volume increments in healthy subjects (36).…”

Section: Somatostatinmentioning

confidence: 99%

The Role of GI Peptides in Functional Dyspepsia and Gastroparesis: A Systematic Review

et al. 2020

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Functional dyspepsia (FD) and gastroparesis (GP) are common disorders of the upper gastrointestinal tract. The pathophysiology of these conditions is likely to be heterogenous, and factors such as altered motility, sensitivity and response to nutrition have been identified as putative underlying mechanisms. Motility, sensitivity as well as responses to nutrition can be influenced or mediated by peptide hormones and serotonin released from the gastrointestinal mucosa. This review summarizes the role of GI peptides in functional dyspepsia and gastroparesis. In most studies, the levels of somatostatin, ghrelin, and motilin did not differ between healthy volunteers and FD or GP patients, but higher symptom burden was often correlated with higher peptide levels. Ghrelin and motilin receptor agonists showed promising results in improvement of the gastric emptying, but the link with improvement of symptoms is less predictable. Serotonin agonists have a potential to improve symptoms in both FD and idiopathic gastroparesis. Drugs acting on the GLP-1 and on the PYY receptors deserve further investigation. There is a need for systematic large scale studies.

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“…), ( N ‐[4‐[2‐(dimethylamino)‐ethoxy]benzyl]‐3,4‐dimethoxybenzamide hydrochloride) is a substituted benzamide that has prokinetic and antiemetic actions . It stimulates gastrointestinal motor activity through the synergistic effects of dopamine D2 receptor blockade and acetylcholine esterase inhibition . Domperidone (DOM, Fig.…”

Section: Introductionmentioning

confidence: 99%

Fourth‐derivative synchronous spectrofluorimetry and HPLC with fluorescence detection as two analytical techniques for the simultaneous determination of itopride and domperidone

Ibrahim

Nasr

2015

Luminescence

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Two simple, rapid and sensitive methods, namely, fourth-derivative synchronous spectrofluorimetry (method I) and HPLC with fluorescence detection (method II) were developed for the simultaneous analysis of a binary mixture of itopride HCl (ITP) and domperidone (DOM) without prior separation. The first method was based on measuring the fourth derivative of the synchronous fluorescence spectra of the two drugs at Δλ = 40 nm in methanol. The different experimental parameters affecting the synchronous fluorescence of the studied drugs were carefully optimized. Chromatographic separation was performed in < 6.0 min using a RP C18 column (250 mm × 4.6 mm i.d., 5 µm particle size) with fluorescence detection at 344 nm after excitation at 285 nm. A mobile phase composed of a mixture of 0.02 M phosphate buffer with acetonitrile in a ratio of 55 : 45, pH 4.5, was used at a flow rate of 1 mL/min. Linearity ranges were found to be 0.1-2 µg/mL for ITP in both methods, whereas those for DOM were found to be 0.08-2 and 0.05-1.5 µg/mL in methods I and II, respectively. The proposed methods were successfully applied for the determination of the studied drugs in synthetic mixtures and laboratory-prepared tablets.

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Effects of Itopride Hydrochloride on Plasma Gut-Regulatory Peptide and Stress-Related Hormone Levels in Healthy Human Subjects

Cited by 24 publications

References 61 publications

The effects of itopride on oesophageal motility and lower oesophageal sphincter function in man

The effects of itopride on oesophageal motility and lower oesophageal sphincter function in man

The Role of GI Peptides in Functional Dyspepsia and Gastroparesis: A Systematic Review

Fourth‐derivative synchronous spectrofluorimetry and HPLC with fluorescence detection as two analytical techniques for the simultaneous determination of itopride and domperidone

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