Effects of Juglone and Curcumin Administration on Expression of FABP5 and FABP9 in MCF-7 and MDA-MB-231 Breast Cancer Cell Lines

Soyler, Dilek; Korucu, Emine Nedime; Menevşe, Esma; Azzawri, A. A.; Kaya, D. E.

doi:10.1134/s199074782310001x

Cited by 1 publication

(1 citation statement)

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“…Alkannin, juglone, lapachol, and lawsone are hydroxy derivatives of 1,4-naphthoquinone skeleton differing in terms of the positions of their carrying-hydroxy and/or side chain groups that determine their activity profiles. Diverse activities including their antitumoral features along with the background mechanisms as well as their dyeing properties are well-studied in previous investigations [ 26 – 33 ]. When it comes to the tricyclic anthraquinone derivatives which comprise a huge part of our research, anthraquinone aglycones, their glycosides, and their dimers have been examined for their therapeutic potential to date.…”

Section: Introductionmentioning

confidence: 99%

Structure-activity relationship of anticancer drug candidate quinones

ÖZENVER,

SÖNMEZ,

BARAN

et al. 2024

Turkish Journal of Chemistry

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Breast cancer is one of the most prevalent cancer types worldwide. Chemotherapy is a substantial approach in the management of breast cancer despite the occurrence of chemotherapy-associated side effects and the development of multidrug resistance in cancer cells. At this point, a variety of quinone derivatives may represent potential as possible anticancer drug candidates due to possessing structural similarity towards clinically used anticancer drugs like doxorubicin. Therefore, we investigated the cytotoxic effects of various quinone derivatives with structural diversity towards a variety of breast cancer cells. We further determined their toxicity in healthy cells to evaluate their drug capability potential. Eighteen quinone derivatives (arbutin, hydroquinone, alkannin, lapachol, lawsone, juglone, aloe-emodin, aloin, cascaroside A (8-O- β -D-glucoside of 10-C -β -D-glucosyl aloe-emodin anthrone), chrysophanol, chrysophanol-8-O- β -D-glucoside, emodin, emodin-8-O- β -D-glucoside, frangulin A (emodin-6-O- a -L-rhamnoside), physcion, rhein, sennoside A, sennoside B (sennoside A and sennoside B are stereoisomers and rhein-dianthrone diglycosides in which β -D-glucose units are bound to the OH groups of rhein anthrones at their 8 th positions) were tested on MCF-7, SK-BR-3, MDA-MB-468, and MDA-MB-231 breast cancer cells and on H9c2 healthy rat cardiac myoblast cells in terms of their cytotoxicity and toxicity, respectively. The resazurin reduction assay was used to determine the cytotoxicity. Among the tested compounds, two naphthoquinone derivatives alkannin and juglone exhibited remarkable cytotoxicity on breast cancer cells and exhibited alleviated toxicity profiles on healthy cells deserving further investigation as possible drug candidates against breast cancer. Structure-activity relationships of these compounds were also evaluated and discussed. Alkannin and juglone, which are naphthoquinone derivatives isolated from natural sources, may be promising agents in the development of drug-candidate molecules with increased efficacy and safety for breast cancer.

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Section: Introductionmentioning

confidence: 99%