Effects of Kanamycin Administration to Poultry on the Proliferation of Drug-Resistant Salmonella

Gast, Richard K.; Stephens, J. F.

doi:10.3382/ps.0670689

Cited by 15 publications

(4 citation statements)

References 23 publications

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“…These mechanisms involve transfer of drug resistant genes by means of circular DNA plasmids such as R-factor, conjugative plasmid, or chromosomal elements [115][116][117][118][119][120][121][122]. The occurrence and proliferation of antibiotic-resistant Salmonella in environmental samples, poultry, and other animals and humans may be due to the use of medicated feeds [123][124][125], the practice of dipping hatching eggs in solutions containing antimicrobial agents [126][127][128], routine inoculation of day-old poults with antibiotics [126][127][128] and treatment of other animals [129] and humans [117] with antibiotics. Salmonella strains of avian origin are also often resistant to variety of antimicrobials approved for poultry including tetracycline [130][131][132][133], oxytetracycline [134], penicillin [66,[130][131][132][133][134], aminoglycosides [130,132,133], sulfisoxazole [133] and fluoroquinolones [135].…”

Section: Risk Factorsmentioning

confidence: 99%

Avian Colibacillosis and Salmonellosis: A Closer Look at Epidemiology, Pathogenesis, Diagnosis, Control and Public Health Concerns

Kabir

2010

IJERPH

358

272

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Avian colibacillosis and salmonellosis are considered to be the major bacterial diseases in the poultry industry world-wide. Colibacillosis and salmonellosis are the most common avian diseases that are communicable to humans. This article provides the vital information on the epidemiology, pathogenesis, diagnosis, control and public health concerns of avian colibacillosis and salmonellosis. A better understanding of the information addressed in this review article will assist the poultry researchers and the poultry industry in continuing to make progress in reducing and eliminating avian colibacillosis and salmonellosis from the poultry flocks, thereby reducing potential hazards to the public health posed by these bacterial diseases.

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Section: Risk Factorsmentioning

confidence: 99%

Avian Colibacillosis and Salmonellosis: A Closer Look at Epidemiology, Pathogenesis, Diagnosis, Control and Public Health Concerns

Kabir

2010

IJERPH

358

272

View full text Add to dashboard Cite

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“…and the duration of the experiments was much shorter (only 11-21 d) than the 42 d reported here. In contrast, Dafuang et al (1987) (Smith 1971;Scioli et al 1983;Gast and Stephens 1988) might still occur at this allowable level.…”

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confidence: 89%

Effects of route and level of administration of procaine penicillin on the performance of broiler chickens

Proudfoot¹,

Hamilton²,

Jackson³

et al. 1993

Can. J. Anim. Sci.

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Three experiments were done to determine the effects of administering procaine penicillin G to broiler chickens. In exps. 1 and 2, groups of 100 male, day-old chicks received one of the following treatments: (1) control, no penicillin; (2) 27.5 mg penicillin kg−1 added to the diet; (3) an amount of penicillin added to the drinking water equivalent to the amount consumed the previous day by the birds in group 2; and (4) same route of administration as group 3, except the dose was one half of the daily intake by group 3. In exp. 3, both female and male (1200 each) broiler chickens were given diets that contained either 0, 1.1, 2.2 or 4.4 mg kg−1 of penicillin. Each experiment was terminated when the birds were 42 d of age. Route or level of penicillin administration had no effect (P > 0.05) on mortality or feed conversion in any of the experiments. When the penicillin was added to the diets of the birds in exps. 1 and 2, their body weights at 21 and 42 d were 3.5 and 2.9%, respectively, less than those of the control group, but when it was administered via the drinking water the weights were 1–3% higher at these ages than those of the control group. Lower monetary returns (> 0.05) were obtained for the chickens in the penicillin groups than in the control group; these differences (6.6–15.6%) were due mainly to the cost of the antibiotic. In exp. 3, higher body weights (P < 0.05) at 21 d (3.6–5.4%) but not (P > 0.05) at 42 d were obtained for the birds given penicillin-supplemented diets than for those fed the control diets. No measurable levels of residue (limit of detection 100 μg kg−1) were found in samples of kidney, liver and muscle (breast and thigh) from birds in exp. 2, which had received 27.5 mg penicillin kg−1 for the 42-d experimental period. Key words: Broiler chickens, growth promoter, procaine penicillin, route of administration, residue levels

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“…Pharmacokinetics of kanamycin has boon discussed previously in ruminants (George et al, 1986;Rule et al, 1988;Lashev et al, 1992) and in non-ruminants (Fox and Russell, 1987;Feodorov et al, 198 . 7;Firth et al, 1988;Gast and Stephens, 1988). Depending on the ionization constant of drugs, the biodisposition is determined different body fluid compartments by the value of pH.…”

Section: Introductionmentioning

confidence: 99%

Studies on Biodisposition Kinetics and Urinary Excretion of Kanamycin in Goats

Nafeesa¹,

Iqbal²,

Shiekh³

et al. 2000

Pakistan J. of Biological Sciences

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The biodisposition kinetin and urinary excretion of kanamycin was investigated in eight normal adult female goats of beetle breed after intravenous close of 5 mg/kg to each gear. After single intravenous administration of kanamycin. in goats, the distribution half-life and biological hall-life had average of 8.1±0.893 min and 2.87±0.12 hrs and ranged between 4.28 to 11.61minutes and 2.44 to 3.37 hrs respectively. The aapparent volume of distribution of kanamycin in goat calculated by area method was 584.6±34.21 mg/kg. The rate constants for Lananivein transfer across compartment 1 to 2, K 12 and 2 to 1, K 21 were 1.846±0.316 hrG 1 and 3.800±0.434 hr and ranged between 1.016 to 3.713 hrG 1 and 2.45 to 5.77 hrG 1 , respectively. Total body clearance of kanarnycin calculated on per kg basis ranged 1.79 to 3.59 ml/min/kg with an average value 2.389±0.194 ml/min/kg, Cumulative urinary excretion as percent of total does excreated at 12 hours was 10.266±1.233. The studies showed variation in pharmacokinetic behaviour of kanamycia in indigenous goats as compared to earlier studies.

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Effects of Kanamycin Administration to Poultry on the Proliferation of Drug-Resistant Salmonella

Cited by 15 publications

References 23 publications

Avian Colibacillosis and Salmonellosis: A Closer Look at Epidemiology, Pathogenesis, Diagnosis, Control and Public Health Concerns

Avian Colibacillosis and Salmonellosis: A Closer Look at Epidemiology, Pathogenesis, Diagnosis, Control and Public Health Concerns

Effects of route and level of administration of procaine penicillin on the performance of broiler chickens

Studies on Biodisposition Kinetics and Urinary Excretion of Kanamycin in Goats

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