Effects of KCA-012 on Bone Metabolism in Organ Culture

Abstract

ABSTRACT-3,9-Dihydroxy-5H-benzofuro[3,2-c]quinoline-6-one (KCA-012), the chemical structure of which is closely similar to that of the phytoestrogen coumestrol, inhibited parathyroid hormone-, 1a,25-dihydroxyvitamin D3-and prostaglandin E2-induced bone resorption of cultured fetal rat bones. KCA-012 also increased the calcium content of 9-day chick embryonic femur cultured in vitro. KCA-012 did not show any estrogenic activity as determined by an increase in the uterine weight of ovariectomized rats, whereas coumestrol did. These results indicate that KCA-012 has no estrogenic activity and has unique effects of inhibiting bone resorption and stimulating bone mineralization.

Block by Phytoestrogens of Recombinant Human Neuronal Nicotinic Receptors

“…In fact, it was reported that daidzein and genistein increased estrogen-specific human alkaline phosphatase activity (1). Phytoestrogens also exhibited estrogenic actions on bone metabolism (2) and vasodilation (3). On the other hands, beneficial effects of phytoestrogens against cardiovascular disease and cancer have been reported (4,5).…”