Effects of Ketamine on Serum and Tracheobronchial Aspirate Interleukin-6 Levels in Infants Undergoing Cardiac Surgery

Zeyneloğlu, Pınar; Dönmez, Aslı; Bilezikçi, Banu; Mercan, Şükrü

doi:10.1053/j.jvca.2005.03.010

Cited by 17 publications

(7 citation statements)

References 26 publications

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“…Nevertheless, at present, the studies conducted in a pediatric population failed to report any beneficial effect of ketamine on the postoperative inflammatory reaction [48][49][50].…”

Section: Anti-proinflammatory Effectmentioning

confidence: 85%

Something new about ketamine for pediatric anesthesia?

Lois

Kock

2008

Current Opinion in Anaesthesiology

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“…Nevertheless, at present, the studies conducted in a pediatric population failed to report any beneficial effect of ketamine on the postoperative inflammatory reaction [48][49][50].…”

Section: Anti-proinflammatory Effectmentioning

confidence: 85%

Something new about ketamine for pediatric anesthesia?

Lois

Kock

2008

Current Opinion in Anaesthesiology

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“…Another study conducted in a pediatric cardiac surgery population failed to demonstrate any anti‐inflammatory action of ketamine after ECC. The administration of steroids in both the control and the ketamine groups probably explains this negative result . In patients undergoing liver transplantation, ketamine administration was associated with reduced levels of circulating TNF‐α and IL‐6 .…”

Section: Ketamine As a “Regulator” Of The Inflammatory Reaction: Clinmentioning

confidence: 99%

Ketamine and Peripheral Inflammation

2013

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The old anesthetic ketamine has demonstrated interactions with the inflammatory response. This review intends to qualify the nature and the mechanism underlying this interaction. For this purpose, preclinical data will be presented starting with the initial works, and then, the probable mechanisms will be discussed. A summary of the most relevant clinical data will be presented. In conclusion, ketamine appears as a unique "homeostatic regulator" of the acute inflammatory reaction and the stress-induced immune disturbances. This is of some interest at a moment when the short- and long-term deleterious consequences of inadequate inflammatory reactions are increasingly reported. Large-scale studies showing improved patient's outcome are, however, required before to definitively assert the clinical reality of this positive effect.

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“…Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is commonly used in veterinary medicine, pediatric surgery, and neonatal intensive care for its anaesthetic and analgesic properties (Mellon et al 2007). Clinically, ketamine has been shown to be an anti-inflammatory agent acting by decreasing serum levels of interleukin 6 (IL-6) and tumour necrosis factor-alpha (TNFα) in patients undergoing cardiac surgeries and liver transplantation (Roytblat et al 1998;Zeyneloglu et al 2005;Yang et al 2006). In addition, in vitro studies have shown that lipopolysaccharide-activated macrophages ) and glial cells (Tanaka et al 2013) have decreased IL-6, TNFα, and IL-1β gene expression when treated with ketamine.…”

Section: Introductionmentioning

confidence: 99%

Ketamine suppresses hypoxia‐induced inflammatory responses in the late‐gestation ovine fetal kidney cortex

Chang

Zarate

Rabaglino

et al. 2015

The Journal of Physiology

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Key pointsr The fetus responds to decreases in arterial partial pressure of oxygen by redirecting the blood flow mainly to the brain and the heart, at a cost to other peripheral organs like the kidneys.r Renal hypoxia and ischaemia stimulate inflammatory and apoptotic responses. r Ketamine, an NMDA receptor antagonist, is able to reduce renal immune and inflammatory gene expressions stimulated by hypoxia.r Ketamine may have therapeutic potential for protection against ischaemic renal damage in fetuses subjected to acute hypoxia.Abstract Acute fetal hypoxia is a form of fetal stress that stimulates renal vasoconstriction and ischaemia as a consequence of the physiological redistribution of combined ventricular output. Because of the potential ischaemia-reperfusion injury to the kidney, we hypothesized that it would respond to hypoxia with an increase in the expression of inflammatory genes, and that ketamine (an N-methyl-D-aspartate receptor antagonist) would reduce or block this response. Hypoxia was induced for 30 min in chronically catheterized fetal sheep (125 ± 3 days), with or without ketamine (3 mg kg −1 ) administered intravenously to the fetus 10 min prior to hypoxia. Gene expression in fetal kidney cortex collected 24 h after the onset of hypoxia was analysed using ovine Agilent 15.5k array and validated with qPCR and immunohistochemistry in four groups of ewes: normoxic control, normoxia + ketamine, hypoxic control and hypoxia + ketamine (n = 3-4 per group). Significant differences in gene expression between groups were determined with t-statistics using the limma package for R (P ࣘ 0.05). Enriched biological processes for the 427 upregulated genes were immune and inflammatory responses and for the 946 downregulated genes were metabolic processes. Ketamine countered the effects of hypoxia on upregulated immune/inflammatory responses as well as the downregulated metabolic responses. We conclude that our transcriptomics modelling predicts that hypoxia activates inflammatory pathways and reduces metabolism in the fetal kidney cortex, and ketamine blocks or ameliorates this response. The results suggest that ketamine may have therapeutic potential for protection from ischaemic renal damage.

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Effects of Ketamine on Serum and Tracheobronchial Aspirate Interleukin-6 Levels in Infants Undergoing Cardiac Surgery

Cited by 17 publications

References 26 publications

Something new about ketamine for pediatric anesthesia?

Something new about ketamine for pediatric anesthesia?

Ketamine and Peripheral Inflammation

Ketamine suppresses hypoxia‐induced inflammatory responses in the late‐gestation ovine fetal kidney cortex

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