Effects of Ketamine on the Pregnant Uterus

Oats, Jeremy N.; Vasey, D. P.; Waldron, B. A.

doi:10.1097/00006254-198008000-00008

Cited by 3 publications

(3 citation statements)

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“…Ketamine: Ketamine rapidly crosses the placenta; however, no foetal effects have been observed during organogenesis and near delivery in rats, mice, rabbits and dogs . Ketamine increases uterine tone and should be avoided during pregnancy . An in‐depth review of caesarean section in dogs is available…”

Section: Section 3: Pain Management Protocolsmentioning

confidence: 99%

Guidelines for Recognition, Assessment and Treatment of Pain

Mathews¹,

Kronen²,

Lascelles³

et al. 2014

J of Small Animal Practice

267

122

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Section: Section 3: Pain Management Protocolsmentioning

confidence: 99%

Guidelines for Recognition, Assessment and Treatment of Pain

Mathews¹,

Kronen²,

Lascelles³

et al. 2014

J of Small Animal Practice

267

122

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“…14 Additionally, ketamine is reported to increase uterine tone. 15 With widespread prospective trials, the frequency and significance of these concerns may be addressed.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Use of Ketamine for Pain Control With Sickle Cell Crisis in Pregnancy

et al. 2018

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Sickle cell crises occur frequently during pregnancy and are difficult to treat, even with high-dose opioids. Analgesia with ketamine has been suggested as an alternative, but its use during pregnancy is underreported. Two pregnant patients with uncontrolled sickle cell pain were treated with ketamine. Patient A reported no decrease in her pain, but her opioid requirements decreased. Patient B's pain resolved during ketamine administration. No serious maternal or neonatal adverse effects occurred. Ketamine may be considered as an adjunct analgesic in pregnant patients with sickle cell pain, although prospective clinical data are needed to fully assess its efficacy.

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“…General anaesthetics work at the level of the spinal cord and in different areas of the brain, which results in relaxation of the muscles and central nervous system depression, although the exact mechanism of action has not been ascertained[ 125 ]. Thiopentone in late pregnancy showed no significant effect on intrauterine pressure, while ketamine was found to cause a uterine contraction in early pregnancy and no effect in late pregnancy[ 126 ]. Volatile anaesthetics such as halothane, sevoflurane, desflurane, and isoflurane have been shown to inhibit uterine contractility; thus, they may be beneficial in preventing preterm contractions[ 127 ].…”

Section: Preparing For Dr Progression In Pregnant Diabeticsmentioning

confidence: 99%

Review of the management of sight-threatening diabetic retinopathy during pregnancy

Choo¹,

Din²,

Azmi³

et al. 2021

WJD

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Diabetes mellitus (DM) is a noncommunicable disease reaching epidemic proportions around the world. It affects younger individuals, including women of childbearing age. Diabetes can cause diabetic retinopathy (DR), which is potentially sight threatening when severe nonproliferative DR (NPDR), proliferative DR (PDR), or sight-threatening diabetic macular oedema (STDME) develops. Pregnancy is an independent risk factor for the progression of DR. Baseline DR at the onset of pregnancy is an important indicator of progression, with up to 10% of women with baseline NPDR progressing to PDR. Progression to sight-threatening DR (STDR) during pregnancy causes distress to the patient and often necessitates ocular treatment, which may have a systemic effect. Management includes prepregnancy counselling and, when possible, conventional treatment prior to pregnancy. During pregnancy, closer follow-up is required for those with a long duration of DM, poor baseline control of blood sugar and blood pressure, and worse DR, as these are risk factors for progression to STDR. Conventional treatment with anti-vascular endothelial growth factor agents for STDME can potentially lead to foetal loss. Treatment with laser photocoagulation may be preferred, and surgery under general anaesthesia should be avoided. This review provides a management plan for STDR from the perspective of practising ophthalmologists. A review of strategies for maintaining the eyesight of diabetic women with STDR with emphasis on prepregnancy counselling and planning, monitoring and safe treatment during pregnancy, and management of complications is presented.

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Effects of Ketamine on the Pregnant Uterus

Cited by 3 publications

References 0 publications

Guidelines for Recognition, Assessment and Treatment of Pain

Guidelines for Recognition, Assessment and Treatment of Pain

Evaluating the Use of Ketamine for Pain Control With Sickle Cell Crisis in Pregnancy

Review of the management of sight-threatening diabetic retinopathy during pregnancy

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