Effects of ketamine treatment on cocaine-induced reinstatement and disruption of functional connectivity in unanesthetized rhesus monkeys

Maltbie, Eric; Gopinath, Kaundinya; Howell, Leonard L.

doi:10.1007/s00213-019-05204-4

Cited by 5 publications

(2 citation statements)

References 70 publications

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“…Several studies indicate that individuals with a first-degree family history of alcoholism may have a heightened and more prolonged antidepressant response to ketamine, perhaps as a result of epigenetic changes, glutamate subreceptor variations, and environmental factors (30,31). The neural changes associated with a predisposition to alcohol use disorder, and perhaps with disordered use itself, may therefore work to optimize the efficacy of ketamine.…”

Section: Discussionmentioning

confidence: 99%

A Single Ketamine Infusion Combined With Motivational Enhancement Therapy for Alcohol Use Disorder: A Randomized Midazolam-Controlled Pilot Trial

Dakwar

Levin

Hart

et al. 2020

AJP

118

111

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Pharmacotherapy and behavioral treatments for alcohol use disorder are limited in their effectiveness, and new treatments with innovative mechanisms would be valuable. In this pilot study, the authors tested whether a single subanesthetic infusion of ketamine administered to adults with alcohol dependence and engaged in motivational enhancement therapy affects drinking outcomes.Methods: Participants were randomly assigned to a 52minute intravenous administration of ketamine (0.71 mg/kg, N=17) or the active control midazolam (0.025 mg/kg, N=23), provided during the second week of a 5-week outpatient regimen of motivational enhancement therapy. Alcohol use following the infusion was assessed with timeline followback method, with abstinence confirmed by urine ethyl glucuronide testing. A longitudinal logistic mixed-effects model was used to model daily abstinence from alcohol over the 21 days after ketamine infusion.

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Section: Discussionmentioning

confidence: 99%

A Single Ketamine Infusion Combined With Motivational Enhancement Therapy for Alcohol Use Disorder: A Randomized Midazolam-Controlled Pilot Trial

Dakwar

Levin

Hart

et al. 2020

AJP

118

111

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“…Although our sample is a unique subset of the AUD population without comorbid depression, thus arguing against the ketamine response here implicating anti-depressant mechanisms, it is possible that the mood-boosting effects of ketamine interact with other aspects of mysticism in a meaningful way that impacts on treatment outcomes. Interestingly, these mood-enhancing effects may be more pronounced in individuals with a family history of AUD (Luckenbaugh et al, 2012; Maltbie et al, 2019); a majority of our participants had a first-degree family history of alcoholism (Dakwar et al, 2020), perhaps rendering them more susceptible to this response.…”

Section: Limitationsmentioning

confidence: 92%

Mystical-type experiences occasioned by ketamine mediate its impact on at-risk drinking: Results from a randomized, controlled trial

et al. 2020

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Background: Sub-anesthetic ketamine administration may be helpful for substance use disorders. Converging evidence suggests that the efficacy of ketamine for certain conditions may implicate a subset of its psychoactive effects. Aims: The aim of this analysis is to evaluate whether the mystical-type effects of ketamine are critical for clinical efficacy in alcohol-dependent individuals. In this secondary analysis, we determine if a subset of the psychoactive effects of ketamine, the so-called mystical-type experience, mediates the effect of ketamine, when combined with motivational enhancement therapy, on at-risk drinking behavior in alcohol-dependent individuals interested in treatment. Methods: Forty alcohol dependent adults were randomized to either a 52-minute infusion of ketamine or midazolam, which they received on a designated quit-day during the second week of a five-week motivational enhancement therapy regimen. Psychoactive effects were assessed following the infusion, and alcohol use was monitored for the subsequent 3 weeks at each twice-weekly visit. Results: We found that ketamine leads to significantly greater mystical-type effects (by Hood Mysticism Scale) and dissociation (by Clinician Administered Dissociative States Scale) compared to the active control. Ketamine also led to significant reduction in at-risk drinking. The Hood Mysticism Scale, but not Clinician Administered Dissociative States Scale score, was found to mediate the effect of ketamine on drinking behavior. Conclusions: This trial adds evidence to the literature on the importance of mystical-type experiences in addiction treatment. Future research should continue to investigate the relationship between the psychoactive effects of psychedelic therapeutics and clinical outcomes for other substance use and mental health disorders.

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Glutamatergic Agents for the Treatment of Cocaine Use Disorder

Hadizadeh

Flores

Mayerson

et al. 2022

Curr Behav Neurosci Rep

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Effects of ketamine treatment on cocaine-induced reinstatement and disruption of functional connectivity in unanesthetized rhesus monkeys

Cited by 5 publications

References 70 publications

A Single Ketamine Infusion Combined With Motivational Enhancement Therapy for Alcohol Use Disorder: A Randomized Midazolam-Controlled Pilot Trial

A Single Ketamine Infusion Combined With Motivational Enhancement Therapy for Alcohol Use Disorder: A Randomized Midazolam-Controlled Pilot Trial

Mystical-type experiences occasioned by ketamine mediate its impact on at-risk drinking: Results from a randomized, controlled trial

Glutamatergic Agents for the Treatment of Cocaine Use Disorder

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