Effects of Ketanserin &amp;ndash; a Serotonin Receptor Antagonist &amp;ndash; on Placental Blood Flow, Placental Weight and Fetal Weight of Spontaneously Hypertensive Rats and Normal Wistar Kyoto Rats

Furuhashi, N; Tsujiei, M.; Kimura, H.; Yajima, Akira

doi:10.1159/000292996

Cited by 16 publications

(6 citation statements)

References 9 publications

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“…Reduced fetal weight has been noted previously in the SHR (Ahokas et al 1986) but placental weights were not reported. However, two Japanese studies reported no difference in either fetal or placental weights between SHRs and WKY rats (Furuhashi et al 1991(Furuhashi et al , 1992. Unfortunately, comparisons of results from different centres using SHRs and WKY rats can present difficulties because it is now known that not all SHRs or WKY rats constitute single inbred strains.…”

Section: Discussionmentioning

confidence: 99%

Fetal growth retardation and increased placental weight in the spontaneously hypertensive rat

Johnston

1995

Reprod. Fertil. Dev.

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Epidemiological studies have linked low birth weight and increased placental weight with increased risk of hypertension in adult life. It has been proposed that the cardiovascular changes which lead to hypertension are initiated in utero by processes associated with intrauterine growth retardation. The alternative possibility, that hypertension may result from genetic influences which also determine fetal and placental size, has had less support because birth weight is not determined genetically in humans. However, in the spontaneously hypertensive rat (SHR) essential hypertension is known to be transmitted genetically. Fetal and placental weights were, therefore, measured at Day 20 gestation in SHRs and compared with those in the normotensive Wistar Kyoto (WKY) control strain. Fetal weight (1.93 +/- 0.04 g) was significantly (P < 0.001) reduced in SHRs compared with WKY fetuses (2.23 +/- 0.01 g) but placental weight was heavier (P < 0.001) in SHRs (0.347 +/- 0.005 g) than in WKY rats (0.300 +/- 0.006 g) although litter size was not different. As expected, maternal blood pressure recorded under 1% halothane anaesthesia was higher (126 +/- 2.7 mm Hg) in SHR than WKY rats (100 +/- 2.1 mm Hg; 1 mm Hg = 133 Pa). In addition the concentration of maternal blood glucose in SHR was significantly (P < 0.001) higher (4.8 +/- 0.32 mM v. 3.7 +/- 0.11 mM) and the concentration of plasma insulin was significantly (P < 0.05) lower in SHRs (18.8 +/- 3.0 ng mL-1) than in WKY dams (29.4 +/- 3.1 ng mL-1). Thus, the data support human population studies which show an association between adult hypertension and a reduced fetal:placental weight ratio at birth. However, because hypertension in the SHR is genetically determined, these data suggest that fetal growth retardation and increased placental weight may also be determined genetically.

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Section: Discussionmentioning

confidence: 99%

Fetal growth retardation and increased placental weight in the spontaneously hypertensive rat

Johnston

1995

Reprod. Fertil. Dev.

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“…It is well known that antihypertensive treatment for pre eclampsia results in a concomitant significant decrease of uteroplacental blood flow, which in turn adversely affects the oxygen supply to the fetus. In this study, we measured the placental blood flow in the PGK-treated rats with the clearance method using electroiytically generated hydro gen in order to investigate the effects of PGH on the pla cental blood flow as previously reported [21,22], The effect of exogenous PGH reduced placental blood flow in the SHR groups; on the other hand, the placental blood flow increased in the WKY 0.5-mg-treated group ( fig. 3).…”

Section: Discussionmentioning

confidence: 86%

Effects of Exogenous Prostacyclin on Placental Blood Flow, Placental Weight and Fetal Weight in Normotensive and Spontaneously Hypertensive Rats

Furuhashi¹,

Tsujiei²,

Kimura³

et al. 1992

Gynecol Obstet Invest

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Recently, prostacyclin (PGI₂) has been used for the treatment of preeclampsia. In this study, we investigated the effects of PGI₂ on placental blood flow (measured with clearance of hydrogen gas generated by electrolysis) in normotensive Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). The placental blood flow of PGI₂-treated SHR (0.25, 0.5 and 1 mg/kg) was significantly (p < 0.05) reduced compared with WKY. These data suggest that PGI₂ has a certain reducing effect on placental blood flow in SHR; on the other hand, in WKY, it has an increasing effect depending on the dose.

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“…We used a model of the instrument for evaluating the clearance of hydrogen gas generated by electrolysis made by Biomedical Science Co. (Kanazawa, Japan) as reported in our previous study [ 17,18].…”

Section: Methodsmentioning

confidence: 99%

Effects of Thromboxane Synthetase Inhibitor (OKY-046) on Placental Blood Flow, Placental Weight and Fetal Weight in Normotensive and Spontaneously Hypertensive Rats

Furuhashi¹,

Tsujiei²,

Kimura³

et al. 1993

Gynecol Obstet Invest

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Recently, thromboxane synthetase inhibitor has been used for the treatment of preeclampsia. In this study, we investigated the effects of thromboxane synthetase inhibitor (OKY-046) on placental blood flow (measured with clearance of hydrogen gas generated by electrolysis) in normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). The systolic blood pressure of OKY-046-treated SHR (1,4 and 8 mg/kg) decreased significantly (p < 0.05); however, the systolic blood pressure of WKY did not decrease. The placental blood flow of both OKY-046-treated WKY and SHR did not decrease. We found that OKY-046 has no reducing effect on placental blood flow in rats, and systolic blood pressure of SHR decreases. These data suggest that thromboxane synthetase inhibitor might have a beneficial effect on preeclampsia.

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Effects of Ketanserin – a Serotonin Receptor Antagonist – on Placental Blood Flow, Placental Weight and Fetal Weight of Spontaneously Hypertensive Rats and Normal Wistar Kyoto Rats

Cited by 16 publications

References 9 publications

Fetal growth retardation and increased placental weight in the spontaneously hypertensive rat

Fetal growth retardation and increased placental weight in the spontaneously hypertensive rat

Effects of Exogenous Prostacyclin on Placental Blood Flow, Placental Weight and Fetal Weight in Normotensive and Spontaneously Hypertensive Rats

Effects of Thromboxane Synthetase Inhibitor (OKY-046) on Placental Blood Flow, Placental Weight and Fetal Weight in Normotensive and Spontaneously Hypertensive Rats

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