Effects of Korean red ginseng extract on the prevention of atopic dermatitis and its mechanism on early lesions in a murine model

Cho, Eujin; Cho, Sang Hyun

doi:10.1016/j.jep.2012.11.006

Cited by 32 publications

(35 citation statements)

References 36 publications

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“…In a TNCB-induced AD mouse model, Korean Red Ginseng significantly reduced the total clinical severity score, ear thickness, and the level of thymic stromal lymphopoietin (TSLP) and TNF-α [33], [34]. Additionally, Korean Red Ginseng ethanol extract improved skin lesions and reduced the Th2-activated cytokines, such as IL-4, IL-10, and the serum IgE levels.…”

Section: Discussionmentioning

confidence: 99%

Korean Red Ginseng improves atopic dermatitis-like skin lesions by suppressing expression of proinflammatory cytokines and chemokines in vivo and in vitro

Kee

Jeon

Kim

et al. 2017

Journal of Ginseng Research

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BackgroundThe prevalence of allergic inflammatory diseases such as atopic dermatitis (AD), asthma, and allergic rhinitis worldwide has increased and complete recovery is difficult. Korean Red Ginseng, which is the heat-processed root of Panax ginseng Meyer, is widely and frequently used as a traditional medicine in East Asia. In this study, we investigated whether Korean Red Ginseng water extract (RGE) regulates the expression of proinflammatory cytokines and chemokines via the mitogen-activated protein kinases (MAPKs)/nuclear factor kappa B (NF-κB) pathway in allergic inflammation.MethodsCompound 48/80-induced anaphylactic shock and 1-fluoro-2,4-dinitrobenzene (DNFB)-induced AD-like skin lesion mice models were used to investigate the antiallergic effects of RGE. Human keratinocytes (HaCaT cells) and human mast cells (HMC-1) were also used to clarify the effects of RGE on the expression of proinflammatory cytokines and chemokines.ResultsAnaphylactic shock and DNFB-induced AD-like skin lesions were attenuated by RGE administration through reduction of serum immunoglobulin E (IgE) and interleukin (IL)-6 levels in mouse models. RGE also reduced the production of proinflammatory cytokines including IL-1β, IL-6, and IL-8, and expression of chemokines such as IL-8, thymus and activation-regulated chemokine (TARC), and macrophage-derived chemokine (MDC) in HaCaT cells. Additionally, RGE decreased the release of tumor necrosis factor-α (TNF-α), IL-1β, IL-6, and IL-8 as well as expressions of chemokines including macrophage inflammatory protein (MIP)-1α, MIP-1β, regulated on activation, normal T cell expressed and secreted (RANTES), monocyte chemoattractant protein (MCP)-1, and IL-8 in HMC-1 cells. Furthermore, our data demonstrated that these inhibitory effects occurred through blockage of the MAPK and NF-κB pathway.ConclusionRGE may be a useful therapeutic agent for the treatment of allergic inflammatory diseases such as AD-like dermatitis.

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Section: Discussionmentioning

confidence: 99%

Korean Red Ginseng improves atopic dermatitis-like skin lesions by suppressing expression of proinflammatory cytokines and chemokines in vivo and in vitro

Kee

Jeon

Kim

et al. 2017

Journal of Ginseng Research

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“…As supplementation with red ginseng is believed to improve health, numerous studies have been conducted to validate its beneficial effects. They demonstrated that RGEs had anti-inflammatory [12, 13], antidiabetic [14, 15], and anticancer [16] effects. Anti-inflammatory property of RGE leads to the understanding that it may have antiarthritic effect via modulating inflammation.…”

Section: Introductionmentioning

confidence: 99%

Red Ginseng Extract Ameliorates Autoimmune Arthritis via Regulation of STAT3 Pathway, Th17/Treg Balance, and Osteoclastogenesis in Mice and Human

Jhun

Lee

Byun

et al. 2014

Mediators of Inflammation

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Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic joint inflammation. Red ginseng is a steamed and dried Panax ginseng C.A. Meyer, which has been used as alternative medicine for thousands of years. This study was undertaken to investigate the effects of red ginseng extracts (RGE) on autoimmune arthritis in mice and humans and to delineate the underlying mechanism. RGE was orally administered three times a week to mice with arthritis. Oral administration of RGE markedly ameliorated clinical arthritis score and histologically assessed joint inflammation in mice with CIA. A significant reduction in STAT3 phosphorylation and a decrease in the number of Th17 cells were observed with RGE treatment. There was also a marked reduction in RANKL-induced osteoclastogenesis with treatment of RGE. The inhibitory effect of RGE on Th17 differentiation and osteoclastogenesis observed in mice was also confirmed in the subsequent experiments performed using human peripheral blood mononuclear cells. Our findings provide the first evidence that RGE can regulate Th17 and reciprocally promote Treg cells by inhibiting the phosphorylation of STAT3. Therefore, RGE can ameliorate arthritis in mice with CIA by targeting pathogenic Th17 and osteoclast differentiation, suggesting a novel therapy for treatment of RA.

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“…They also found that RG extract suppressed the ear thickness, IgE levels in the blood, and regulatory (FOXP3 + ) T cell and Langerhans cell (CD1a + ) populations in the lesions of TNCB-sensitized NC/Ng mice [50]. Treatment with RG inhibited thymic stromal lymphopoietin (TSLP) and TNF-α expression and Langerhans cell populations in NC/Nga mice with TNCB-induced AD [51]. Kim et al reported that topical application of RG significantly suppressed the clinical skin severity score in NC/Nga mice with TNCB-induced AD [52].…”

Section: The In Vitro and In Vivo Anti-allergic Effects Of Ginsengmentioning

confidence: 96%

Effects of Red and Fermented Ginseng and Ginsenosides on Allergic Disorders

Han

Kim

2020

Biomolecules

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Both white ginseng (WG, dried root of Panax sp.) and red ginseng (RG, steamed and dried root of Panax sp.) are reported to exhibit a variety of pharmacological effects such as anticancer, antidiabetic, and neuroprotective activities. These ginsengs contain hydrophilic sugar-conjugated ginsenosides and polysaccharides as the bioactive constituents. When taken orally, their hydrophilic constituents are metabolized into hydrophobic ginsenosides compound K, Rh1, and Rh2 that are absorbable into the blood. These metabolites exhibit the pharmacological effects more strongly than hydrophilic parental constituents. To enforce these metabolites, fermented WG and RG are developed. Moreover, natural products including ginseng are frequently used for the treatment of allergic disorders. Therefore, this review introduces the current knowledge related to the effectiveness of ginseng on allergic disorders including asthma, allergic rhinitis, atopic dermatitis, and pruritus. We discuss how ginseng, its constituents, and its metabolites regulate allergy-related immune responses. We also describe how ginseng controls allergic disorders.

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Effects of Korean red ginseng extract on the prevention of atopic dermatitis and its mechanism on early lesions in a murine model

Cited by 32 publications

References 36 publications

Korean Red Ginseng improves atopic dermatitis-like skin lesions by suppressing expression of proinflammatory cytokines and chemokines in vivo and in vitro

Korean Red Ginseng improves atopic dermatitis-like skin lesions by suppressing expression of proinflammatory cytokines and chemokines in vivo and in vitro

Red Ginseng Extract Ameliorates Autoimmune Arthritis via Regulation of STAT3 Pathway, Th17/Treg Balance, and Osteoclastogenesis in Mice and Human

Effects of Red and Fermented Ginseng and Ginsenosides on Allergic Disorders

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