Effects of L-Arginine supplementation of drinking water on the kidney and liver of Sasso chickens

Abstract

The present study was conducted to determine the effects of L-arginine supplementation of drinking water on the kidney and liver of Sasso chickens. The study comprised 297 mixed sex Sasso chickens of twelve-weeks old raised in floor pens; the birds were randomly distributed into three treatments and three replicates with thirty-three birds per replicate. The design of the experiment is the completely randomized design (CRD). The birds were fed grower's mash and given different treatment of 0 mg/L (Treatment A at 0% supplementation), 167 mg/L (Treatment B at 50% supplementation), and 334 mg/L (Treatment C at 100% supplementation) of L-arginine supplement in drinking water of 9 L per replicate daily for a period of five consecutive weeks, after which the birds were decapitated. The kidney and liver were removed and taken to histopathology laboratory for histological analysis. The chickens administered 0 mg/L L-arginine (0%) supplementation was without lesions. However, kidney and liver of chickens that received 167 mg/L (50%) and 334 mg/L (100%) supplementation showed explicit damage. There was congestion of the vascular channels in the kidneys and liver of birds that received 167 mg/L of L-arginine and destruction of the glomeruli and tubules in the kidney and peri portal mononuclear inflammatory infiltration in the liver of those given 334 mg/L of L-arginine. This could possibly be a result of the over-expression of nitric oxide which is a vasodilator. These present findings showed that supplementing the diets of Sasso chickens with L-arginine of 50 and 100% have detrimental effect on the structure and functions of the kidney and liver.

Effect of In Ovo Injection of L-Arginine in Different Chicken Embryonic Development Stages on Post-Hatchability, Immune Response, and Myo-D and Myogenin Proteins

“…The hepatocyte gap appeared in normal architecture in the 1C, 1C1, 2C1, 3C1, 1T1, and 2T2 groups. The degeneration of livers was observed for birds when treated with 167 and 334 mg/L of L-Arg, which had an adverse effects on organs [60]. The liver after treatment with L-Arg (334 mg/L) had congested vascular spaces and periportal mononuclear inflammatory infiltration [61].…”

Effect of in ovo Injection of L-Arginine in Different Chicken Embryonic Development Stages on Post-hatch Growth Performance, Immune Response and Muscle Development Proteins

“…The hepatocyte gap appears in normal architecture in 1C, 1C1, 2C1, 3C1, 1T1, and 2T2. Degeneration of livers were observed for birds when treated with 167 and 334 mg/L of L-Arg had adverse effects on organs [52]. The liver after treatment with L-Arg (334mg/L) had congested vascular spaces and periportal mononuclear inflammatory infiltration [53].…”