Effects of L-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and nitric oxide production after exercise

Sureda, Antoni; Córdova, Alfredo; Ferrer, Miguel D.; Tauler, Pedro; Pérez, Gerardo; Tur, Josep A.; Pons, Antoni

doi:10.1080/10715760903071664

Cited by 69 publications

(78 citation statements)

References 52 publications

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“…Much evidence suggests that L-citrulline can decrease suppress oxidative damage induced by exhaustive exercise. 15 Moreover, L-citrulline can become the effective precursor of L-arginine which is a substrate for endothelial NO synthase (eNOS) via the L-citrulline/L-arginine pathway, and plays an important role in the metabolism and regulation of NO. 16 Others demonstrated that oral supplementation of L-citrulline can inhibition the increased inducible nitric oxide synthase (iNOS) activity, upregulate endothelial NO synthase (eNOS) activity, and improve endothelial function in animal.…”

Section: Introductionmentioning

confidence: 99%

L-Citrulline Protects Against Glycerol-Induced Acute Renal Failure in Rats

Liu

Gou

et al. 2013

Renal Failure

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There is an increasing evidence that oxidative stress plays an important role in the pathogenesis of rhabdomyolysisinduced acute renal failure (ARF). In this study, protective effects of L-citrulline on glycerol-induced ARF in rats were investigated. Six groups of rats were employed in this study: group 1 served as a control; group 2 was only given glycerol (50%, 10 mL/kg, i.m.); group 3 was given glycerol plus dexamethasone (0.1 mg/kg, i.g.) as positive reference drug, starting at the same time as the glycerol injections; the last three groups were given glycerol plus L-citrulline (300, 600, and 900 mg/kg, i.g.) respectively, starting at the same time as the glycerol injections. The injections of glycerol were only once, and after glycerol injections the i.g. administrations of dexamethasone and L-citrulline were repeated every 24 h for 7 days. After 7 days of glycerol injections, the blood samples and kidney tissues were harvested for future biochemical and pathology analyses. The levels of creatinine (Cr) and urea nitrogen (BUN) in plasma, the content of malondialdehyde (MDA), glutathione (GSH), nitric oxide (NO), the activity of total nitric oxide synthase (TNOS), inducible nitric oxide synthase (iNOS), endothelial NO synthase (eNOS), and superoxide dismutase (SOD) were evaluated in kidney tissues. Consequently, administrations of L-citrulline improved an impaired intrarenal oxygenation and kidney function compared with the glycerol group, and prevented the renal oxidative stress damage as well as severe functional and morphological renal deterioration. Therefore, L-citrulline might have potential application in the amelioration of glycerol-induced ARF.

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Section: Introductionmentioning

confidence: 99%

L-Citrulline Protects Against Glycerol-Induced Acute Renal Failure in Rats

Liu

Gou

et al. 2013

Renal Failure

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“…Cell lysates were stored at −80 °C until biochemical analyses. Venous blood samples were obtained after 12 h, overnight, fasted conditions (basal sample), and 2 h after finishing training as this is coincident with an increment in circulating immune cells, with changes in antioxidant enzymes activities and in markers of oxidative damage [29,30].…”

Section: Methodsmentioning

confidence: 99%

Docosahexaenoic Acid Supplementation Promotes Erythrocyte Antioxidant Defense and Reduces Protein Nitrosative Damage in Male Athletes

Martorell

Capó

Bibiloni

et al. 2014

Lipids

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The aim of this study was to determine the influence of long-term docosahexaenoic acid (DHA) dietary supplementation on the erythrocyte fatty acid profile and oxidative balance in soccer players after training and acute exercise. Fifteen volunteer male athletes (age 20.0 ± 0.5 years) were randomly assigned to a placebo group that consumed an almond-based beverage (n = 6), or to an experimental group that consumed the same beverage enriched with DHA (n = 9) for 8 weeks. Blood samples were taken in resting conditions at the beginning and after 8 weeks of nutritional intervention and training in resting and in post-exercise conditions. Oxidative damage markers (malonyldialdehyde, carbonyl and nitrotyrosine indexes) and the activity and protein level of antioxidant enzymes (catalase, superoxide dismutase, glutathione reductase and peroxidase) were assessed. The results showed that training increased antioxidant enzyme activities in erythrocytes. The experimental beverage increased DHA from 34.0 ± 3.6 to 43.0 ± 3.6 nmol/10(9) erythrocytes. DHA supplementation increased the catalytic activity of superoxide dismutase from 1.48 ± 0.40 to 10.5 ± 0.35 pkat/10(9) erythrocytes, and brought about a reduction in peroxidative damage induced by training or exercise. In conclusion, dietary supplementation with DHA changed the erythrocyte membrane composition, provided antioxidant defense and reduced protein peroxidative damage in the red blood cells of professional athletes after an 8-week training season and acute exercise.

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“…This cycle is physiologically significant because it constantly recycles Cit in order to maintain a sufficient concentration of Arg within cells [66]. For example, male cyclists who received 6 g Cit supplementation prior to cycling events showed increased plasma levels of Cit, Arg and NO concentrations [67]. Cit is therefore of paramount importance in the body.…”

Section: Arginine Synthesismentioning

confidence: 99%