Effects of L-cysteine on lead acetate induced neurotoxicity in albino mice

Mahmoud, Yomna I.; Sayed, S.

doi:10.3109/10520295.2016.1164897

Cited by 27 publications

(9 citation statements)

References 18 publications

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“…2I. The PbAc dose (40 mg/kg body weight "bw") was chosen and given intraperitoneally (ip)according to previous study 77 . The BVJ dose ("1 g BVJ dissolved in distilled water/kg bw = 8 mL juice/kg bw, where 1 g of BVJ contains 17.26 mg galic acid equivalent as total phenolic compounds) was chosen and given orally using oral cavage according to the previous study 78 .…”

Section: Investigation Of the Phytochemical Compositions Of Bvj Usingmentioning

confidence: 99%

Synergistic protective effect of Beta vulgaris with meso-2,3-dimercaptosuccinic acid against lead-induced neurotoxicity in male rats

Shaban

El-Kader

Mogahed

et al. 2021

Sci Rep

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Lead (Pb) toxicity is one of the most prevalent causes of human neurotoxicity. The available chelator drugs used now have many adverse effects. So, in this study, the protective role of Betavulgaris juice (BVJ) on rat neurotoxicity induced by Pb was evaluated and the results were compared with the results of dimercaptosuccinic acid (DMSA, as used drug). Additionally, the synergistic effect of BVJ and DMSA against Pb-induced neurotoxicity was assessed. The study focused on the determination of the antioxidant, anti-inflammatory, and neurological potential of BVJ (alone, and with DMSA) towards lead-induced neurotoxicity. Also, the characterization of BVJ was studied. The results showed that BVJ contains considerable quantities of polyphenols, triterpenoids, and betalains which play an important role as antioxidants and anti-inflammatory. BVJ exhibited a protective effect against neurotoxicity via the reduction of Pb levels in blood and brain. Moreover, BVJ decreased the oxidative stress, inflammation, and cell death induced by Pb. Also, BVJ regulated the activities of acetylcholine esterase and monoamine oxidase-A which changed by Pb toxicity. BVJ and DMSA combination displayed a synergistic antineurotoxic effect (combination index ˂ 1). These results were in harmony with brain histopathology. Conclusion: BVJ has a powerful efficacy in the protection from brain toxicity via diminishing Pb in the brain and blood circulation, resulting in the prevention of the oxidative and inflammatory stress. Treatment with BVJ in combination with DMSA revealed a synergistic effect in the reduction of neurotoxicity induced by Pb. Also, the antioxidant and anti-inflammatory effects of the BVJ lead to the improvement of DMSA therapy.

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Section: Investigation Of the Phytochemical Compositions Of Bvj Usingmentioning

confidence: 99%

Synergistic protective effect of Beta vulgaris with meso-2,3-dimercaptosuccinic acid against lead-induced neurotoxicity in male rats

Shaban

El-Kader

Mogahed

et al. 2021

Sci Rep

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“…Also lightly stained Nissl and numerous chromatolytic cells were observed. Several earlier studies had reported the ability of Pb to cause neuronal degeneration, chromatolysis and distortion of cortical layers [39][40][41][42]. This result indicates that the number of healthy neurons available to carry out normal function within the DLPFC will be low, thereby affecting is the function in working memory (Figure 1).…”

Section: Discussionmentioning

confidence: 92%

Lead acetate-induced neurodegenerative changes in the dorsolateral prefrontal cortex of mice: the role of Vitexin

Amedu

Omotoso

2020

Environ Anal Health Toxicol

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This study was aimed at investigating the neuroprotective effect of Vitexin against lead (Pb) induced neurodegenerative changes in the dorsolateral prefrontal cortex (DLPFC) and working memory in mice. Thirty-two adolescent male albino mice were divided into four groups (n=8). Control group received 0.2 mL of normal saline; Pb group received 100 mg/kg of Pb acetate for 14 days, Vitexin group received 1mg/kg of Vitexin for 14 days, and Pb+Vitexin group received 100 mg/kg of Pb acetate and 1 mgkg of Vitexin for 14 days. Barnes maze test and novel object recognition test were done to ascertain working memory. Histoarchitectural assessment of DLPFC was done with haematoxylin and eosin (H&E), cresyl fast violet and congo red stains. Furthermore, cell count and other morphometric measurements were done. There was significant decline in working memory in the Pb group, but a combination of Pb+Vitexin improved the working memory. Vitexin significantly reduced neuronal death and chromatolysis caused by Pb. Amyloid aggregation was not observed in any of the groups. This study has shown that concurrent administration of Vitexin and Pb will significantly reduce neurodegeneration and improve working memory. However, Pb treatment or Pb+Vitexin treatment does not have any effect on intercellular distance, neuronal length and the cross-sectional area of neurons in layer III of DLPFC.

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“…Group I was given deionised water and served as the control group. Group II received 40 mg/kg bw of lead acetate according to Mahmoud et al [22] Group III received 40 mg/kg bw of lead acetate and 1 mL/kg bw of honey according to Abdulmajeed et al [23] Group IV received 40 mg/kg bw of lead acetate and 100 mg/kg of Vitamin C according to Li et al [24] Group V received 40 mg/kg bw of lead acetate, 1 mL/kg bw honey, and 100 mg/kg bw of Vitamin C. All treatments were coadministered with lead acetate orally for a period of 28 days according to Abdulmajeed et al [23]…”

Section: Animal Groupingmentioning

confidence: 99%

Honey supplemented with Vitamin C prevents dyslipidaemia and oxidative stress induced by exposure to lead acetate in Wistar rats

Adeyomoye

Olaniyan

Adewumi

et al. 2022

IJPP

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Objectives: Lead is an environmental toxicant known to cause dyslipidaemia through oxidative stress damage. The therapeutic potential of honey has widely been reported. However, there is a paucity of reports on its effects on lipid profile in Wistar rats exposed to lead. Materials and Methods: The effects of honey on antioxidants and lipid profile indicators were studied in 25 male Wistar rats. The rats were randomly assigned to one of the five groups (n = 5) as follows: Group I served as the control and received deionised water; Group II served as a lead acetate group (40 mg/kg bw) and Groups III, IV and V served as lead acetate groups coadministered with honey (1 mL/kg bw), Vitamin C (100 mg/kg bw) and honey+Vitamin C, respectively. The treatments were orally administered for 28 days. Body and liver weights were determined using an analytical weighing balance. Glucose and lead concentration, superoxide dismutase (SOD), total antioxidant capacity (TAC), malondialdehyde (MDA), and the lipid profile indicators were determined using spectrophotometry. The liver histology was assessed by haematoxylin and eosin staining techniques. Statistical analysis was done using analysis of variance, and the results were expressed as mean ± S.E.M. at P < 0.05. Results: Body weight, SOD, and TAC increased significantly in the treatment groups compared to lead acetate only. However, lead, glucose concentration, MDA, total cholesterol, triglycerides, HDL, and LDL decreased significantly in the treatment groups compared to lead acetate only. Normal histoarchitecture of the liver was seen in the treatment groups compared to lead acetate, which showed areas of inflammation. Conclusion: These findings imply that honey prevents dyslipidaemia which is a risk factor for metabolic diseases.

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Effects of L-cysteine on lead acetate induced neurotoxicity in albino mice

Cited by 27 publications

References 18 publications

Synergistic protective effect of Beta vulgaris with meso-2,3-dimercaptosuccinic acid against lead-induced neurotoxicity in male rats

Synergistic protective effect of Beta vulgaris with meso-2,3-dimercaptosuccinic acid against lead-induced neurotoxicity in male rats

Lead acetate-induced neurodegenerative changes in the dorsolateral prefrontal cortex of mice: the role of Vitexin

Honey supplemented with Vitamin C prevents dyslipidaemia and oxidative stress induced by exposure to lead acetate in Wistar rats

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