Effects of Labisia pumila on oxidative stress in rat model of post-menopausal osteoporosis

Nurdiana, Nurdiana; Mariati, Nelly; Noorhamdani, Noorhamdani; Setiawan, Bambang; Budhiparama, Nicolaas C.; Noor, Zairin

doi:10.1016/j.apjr.2016.07.015

Cited by 7 publications

(13 citation statements)

References 17 publications

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“…Besides, MDA can inhibit the protein and nucleic acid synthesis and decrease the enzyme activity, resulting in decreased antioxidant substances in the body and thus gradually reducing the bone mass. After OS stimulates the osteoclast growth and differentiation, osteoclasts will in turn produce more ROS, exacerbate the damage to the antioxidant defense mechanism in the body and form a vicious circle, ultimately leading to extensive OP ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

Relationship of melatonin level, oxidative stress and inflammatory status with osteoporosis in maintenance hemodialysis of chronic renal failure

2018

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The relationship of melatonin (MT) level, oxidative stress and inflammatory status with osteoporosis in the maintenance hemodialysis (MHD) of chronic renal failure was investigated. Ninety-four patients with chronic renal failure treated in Dezhou People's Hospital (Dezhoo, China) and receiving MHD for more than 3 months from May to April 2017 were selected and divided into the osteoporosis group (observation group, n=49) and the non-osteoporosis group (control group, n=45) based on whether osteoporosis was involved. The serum advanced oxidation protein products (AOPP), MT level and inflammatory factors [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and IL-1] in patients were detected via enzyme-linked immunosorbent assay (ELISA). Moreover, the malondialdehyde (MDA) level in serum was detected via thibabituric acid (TBA) assay and the spinal bone mineral density (BMD) was detected using the total BMD testing instrument, followed by correlation analysis. The MT level in observation group was significantly lower than that in control group, but the levels of AOPP and MDA were significantly higher than those in control group (P<0.05). The levels of inflammatory factors (TNF-α, IL-6 and IL-1) in observation group were obviously higher than those in the control group (P<0.05). Besides, the spinal BMD and T-value in observation group were significantly lower than those in the control group (P<0.05). Pearson's correlation analysis showed that AOPP, MDA, TNF-α, IL-6 and IL-1 levels were negatively correlated with BMD, but MT was positively correlated with BMD (P<0.05). Osteoporosis occurs easily in MHD patients; oxidative stress and inflammatory degree are negatively correlated with osteoporosis, but MT is positively correlated with osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Relationship of melatonin level, oxidative stress and inflammatory status with osteoporosis in maintenance hemodialysis of chronic renal failure

2018

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“…In addition, five control rats were subjected to sham surgery. Subsequent to ovariectomy, wound care was performed for 10 days and then extract treatment was started [15,16].…”

Section: Procedures For Ovariectomymentioning

confidence: 99%

“…Preparation of L. pumila extracts was performed according our previous study [15,17]. The ethanol extract of L. pumila was administered according to the dose using an oral feeding tube to the ovariectomized rats.…”

Section: Preparation Of Extractsmentioning

confidence: 99%

Effects of Labisia pumila on bone turnover markers and OPG/RANKL system in a rat model of post-menopausal osteoporosis

Nurdiana

Mariati

Noorhamdani

et al. 2018

Clinical Nutrition Experimental

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“…Based on the types of activity, 16 studies focused on antioxidative activities, three studies focused on anti-inflammatory activities and two studies investigated both antioxidative and anti-inflammatory activities of M. pumilum. Animal studies used Sprague Dawley rats [35][36][37], Wistar rats [38][39][40] and ICR mice [36] as the experimental model. In the two in vitro cell culture studies were described in this review, where murine monocytic macrophage cell line RAW 264.7 was used in one study [41] and human peripheral blood mononuclear cells and plasma were used in another study [55].…”

Section: Study Design Characteristicsmentioning

confidence: 99%

“…Several chemical assays such as 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, ferric reducing antioxidant potential (FRAP), oxygen radical absorbance capacity (ORAC), oxygen (O2) radical scavenging, hydrogen peroxide (H2O2) radical scavenging, hydroxyl (OH•) radical scavenging, β-carotene bleaching, nitric oxide (NO) radical scavenging and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging were used in the chemical studies [42][43][44][45][46][47][48][49][50][51][52][53]. Biochemical tests such as superoxide dismutase (SOD), glutathione peroxidise (GPx), and malondialdehyde (MDA) were also used to detect antioxidative activity [37][38][39][40]. Formalin-induced inflammation test, carrageenan-induced paw edema test and arachidonic acid-induced ear edema test were used to investigate anti-inflammatory activity in different studies [35,36].…”

Section: Study Design Characteristicsmentioning

confidence: 99%

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2018

Rec.Nat.Prod.

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Marantodes pumilum is a herbaceous plant that has widely recognized for its medicinal use. The plant used widely has led to many studies on its phytochemical identification, pharmacological and toxicological activities. Phytoconstituents found in the Marantodes pumilum extracts showed high antioxidant and antiinflammatory properties which are essential for many pharmacological effects. The aim of the systematic review is to provide the information of antioxidant and anti-inflammatory properties found in Marantodes pumilum. A critical literature search from three electronic databases such as SCOPUS, EBSCOhost and Ovid Medline was conducted for related studies published from the years 1946 to November 2017. The research studies published in English and related with the antioxidant and anti-inflammatory effects of Marantodes pumilum were the main inclusion criteria in this review. A total 512 relevant articles was identified, whereby 21 articles met the inclusion criteria. Twelve chemical assay studies, five animal studies, two in vitro cell culture study, one combined in vivo animal and chemical study and one combined chemical assay and in vitro cell culture study included in this review. All of the studies reported moderate to noticeable positive effects of Marantodes pumilum against oxidation and inflammation. This systematic review highlights the antioxidant and antiinflammatory effects and their relation with phytoconstituents of Marantodes pumilum extracts.

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Effects of Labisia pumila on oxidative stress in rat model of post-menopausal osteoporosis

Cited by 7 publications

References 17 publications

Relationship of melatonin level, oxidative stress and inflammatory status with osteoporosis in maintenance hemodialysis of chronic renal failure

Relationship of melatonin level, oxidative stress and inflammatory status with osteoporosis in maintenance hemodialysis of chronic renal failure

Effects of Labisia pumila on bone turnover markers and OPG/RANKL system in a rat model of post-menopausal osteoporosis

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