Effects of Lactobacillus plantarum on intestinal integrity and immune responses of egg-laying chickens infected with Clostridium perfringens under the free-range or the specific pathogen free environment

Xu, Tianyue; Chen, Yan; Yu, Longfei; Wang, Jun; Huang, Mingxing; Zhu, Ni

doi:10.1186/s12917-020-2264-3

Cited by 29 publications

(27 citation statements)

References 42 publications

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“…can limit the proliferation of pathogenic bacterial such as Clostridium perfringens , Salmonella spp. and E. coli via bacteriocins, bacteriostatic, and bacteriocidal effects 65–67 and by competitive exclusion of pathogens 66,67 . Our findings agree with those of previous research in which the dietary supplementation of onion bulb reduced E. coli and improved Lactobacillus spp.…”

Section: Resultssupporting

confidence: 92%

Onion leaf and synthetic additives in broiler diet: impact on splenic cytokines, serum immunoglobulins, cecal bacterial population, and muscle antioxidant status

et al. 2021

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BACKGROUND The disadvantages associated with the use of synthetic additives in animal production could threaten human and animal health, and the safety of animal‐derived foods. This study assessed the growth performance, blood chemistry, immune indices, selected caeca bacterial population, muscle antioxidant enzyme activities, and meat quality in broiler chickens fed diet supplemented with antibiotic (70% oxytetracycline +30% neomycin), tert‐butylhydroxytoluene or onion leaf powder (OLP). One day old Ross 308 chicks (n = 240) were assigned randomly to either D‐1, control diet (CD) without additives; D‐2, CD + 0.3 g kg−1 antibiotic +0.15 g kg−1 tert‐butylhydroxytoluene; D‐3, CD + 2.5 g kg−1 OLP; or D‐4, CD + 5 g kg−1 OLP for 42 days. RESULTS The D‐2 and D‐4 diets improved (P < 0.05) bodyweight gain and feed efficiency in broilers. Platelet and cecal Lactobacillus spp. counts were higher (P < 0.05) whereas muscle cholesterol was lower (P < 0.05) in the OLP‐supplemented birds. Supplemented birds had higher (P < 0.01) splenic interleukin‐10 and lower (P < 0.01) splenic tumor necrosis factor‐α, immunoglobulin A, cecal E. coli and C. perfringens counts compared with the D‐1 birds. The D‐4 birds had the least (P < 0.05) splenic interleukin‐1β. Dietary supplements increased (P < 0.05) catalase, glutathione peroxidase, and total antioxidant capacity, and lowered (P < 0.05) drip loss, malondialdehyde and carbonyl content in breast meat. CONCLUSION Dietary supplementation of 5 g kg−1 OLP exerted antimicrobial, immunomodulatory, and antioxidant effects that were comparable to those of antibiotics and tert‐butylhydroxytoluene in broiler chickens. © 2021 Society of Chemical Industry.

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Section: Resultssupporting

confidence: 92%

Onion leaf and synthetic additives in broiler diet: impact on splenic cytokines, serum immunoglobulins, cecal bacterial population, and muscle antioxidant status

et al. 2021

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“…and other Gram-negative bacteria species are common pathogens found in poultry farming [ 99 , 100 ]. These pathogens damage the villus–crypt units and intestinal mucosa of birds, lower the surface area for nutrient digestion and absorption, then reduce overall performance [ 101 , 102 ]. BA and CA are weak organic acids having different antibacterial actions, depending on the pKa value of the acids and intestinal pH [ 38 , 103 ] that cause the death of harmful bacteria in the gut of animals [ 16 , 104 ].…”

Section: Biological Functions Of Ba and Camentioning

confidence: 99%

Butyric and Citric Acids and Their Salts in Poultry Nutrition: Effects on Gut Health and Intestinal Microbiota

Melaku

Zhong

Han

et al. 2021

IJMS

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Intestinal dysfunction of farm animals, such as intestinal inflammation and altered gut microbiota, is the critical problem affecting animal welfare, performance and farm profitability. China has prohibited the use of antibiotics to improve feed efficiency and growth performance for farm animals, including poultry, in 2020. With the advantages of maintaining gut homeostasis, enhancing digestion, and absorption and modulating gut microbiota, organic acids are regarded as promising antibiotic alternatives. Butyric and citric acids as presentative organic acids positively impact growth performance, welfare, and intestinal health of livestock mainly by reducing pathogenic bacteria and maintaining the gastrointestinal tract (GIT) pH. This review summarizes the discovery of butyric acid (BA), citric acid (CA) and their salt forms, molecular structure and properties, metabolism, biological functions and their applications in poultry nutrition. The research findings about BA, CA and their salts on rats, pigs and humans are also briefly reviewed. Therefore, this review will fill the knowledge gaps of the scientific community and may be of great interest for poultry nutritionists, researchers and feed manufacturers about these two weak organic acids and their effects on intestinal health and gut microbiota community, with the hope of providing safe, healthy and nutrient-rich poultry products to consumers.

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“…Administration of a probiotic containing a blend of Saccharomyces and Pediococcus has shown an improvement over the antibody response in Eimeria-challenged broilers [ 3 ]. Recent evidence indicates that probiotics may enhance host defenses against infection because of the bacteria’s effect on host immunity and gut integrity under enteric pathogen challenge [ 7 , 9 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Protective and immunostimulatory effects of in-feed preparations of an anticoccidial, a probiotic, a vitamin-selenium complex, and Ferulago angulata extract in broiler chickens infected with Eimeria species

et al. 2021

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Background Two experiments were conducted to compare the growth-promoting (experiment 1), protective, and immunostimulatory effects (experiment 2) of salinomycin, probiotic, a vitamin-selenium complex, and Ferulago angulata hydroalcoholic extract (FAE) against coccidiosis in broilers. In each experiment, 350 1-day-old broiler chickens were equally divided in 7 groups: uninfected negative control (NC); infected positive control (PC); or PC supplemented with salinomycin (Sal); probiotic (Pro); a combination of vitamin E, vitamin C, and selenium (ECSe); 200 mg/kg of FAE (FAE200); or 400 mg/kg of FAE (FAE400). All these groups (except NC) were challenged via oral gavage with oocysts of mixed Eimeria spp. on d 10 (experiment 1) or d 14 (experiment 2). Results In the first trial, all treatments improved growth and feed conversion compared with the PC group, where the best values were noticed in the NC and FAE400 groups throughout the entire experimental period (d 1 to 42). Further, a lower mortality rate (P < 0.05) was observed in the NC, Sal, and FAE400 groups as compared to that in the PC group. In the second trial, intestinal lesion scores and total oocyst numbers were reduced in the Sal, Pro, and FAE400 groups compared to the PC group, albeit all coccidiosis-challenged groups had higher oocyst shedding (P < 0.05) compared to NC group. Immune responses revealed that among challenged birds, those fed diets Pro, ECSE, and FAE400 had significantly higher primary total and secondary total and IgG antibody titers against sheep red blood cells, serum and cecum specific IgG levels, and serum IFN-γ concentration than the PC group. Conclusions Considering the results, dietary FAE, especially at high levels of inclusion in broiler diet (400 mg/kg), could beneficially influence growth performance and immune status under coccidiosis challenge, which was comparable to that of probiotic supplement.

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Effects of Lactobacillus plantarum on intestinal integrity and immune responses of egg-laying chickens infected with Clostridium perfringens under the free-range or the specific pathogen free environment

Cited by 29 publications

References 42 publications

Onion leaf and synthetic additives in broiler diet: impact on splenic cytokines, serum immunoglobulins, cecal bacterial population, and muscle antioxidant status

Onion leaf and synthetic additives in broiler diet: impact on splenic cytokines, serum immunoglobulins, cecal bacterial population, and muscle antioxidant status

Butyric and Citric Acids and Their Salts in Poultry Nutrition: Effects on Gut Health and Intestinal Microbiota

Protective and immunostimulatory effects of in-feed preparations of an anticoccidial, a probiotic, a vitamin-selenium complex, and Ferulago angulata extract in broiler chickens infected with Eimeria species

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