Effects of Large Doses of Nicotinyl Alcohol on Serum Lipid Levels and Carbohydrate Tolerance

Gaut, Zane N.; Taylor, William G.

doi:10.1002/j.1552-4604.1968.tb00112.x

Cited by 3 publications

(3 citation statements)

References 31 publications

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“…In previous studies, nicotinic acid has been shown to both increase and decrease plasma glucose concentration in normal and diabetic humans and animals (7,(66)(67)(68)(69)(70)(71)(72)(73)(74). The reason for these discrepancies is not clear.…”

Section: Resultsmentioning

confidence: 99%

Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus.

Vaag¹,

Skøtt²,

Damsbo³

et al. 1991

J. Clin. Invest.

120

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IntroductionIncreased nonesterified fatty acid (NEFA) levels may be important in causing insulin resistance in skeletal muscles in patients with non-insulin-dependent diabetes mellitus (NIDDM). The acute effect of the antilipolytic nicotinic acid analogue Acipimox (2 X 250 mg) on basal and insulin-stimulated (3 h, 40 mU/m2 per min) glucose metabolism was therefore studied in 12 patients with NIDDM. Whole-body glucose metabolism was assessed using 13-3Hjglucose and indirect calorimetry.Biopsies were taken from the vastus lateralis muscle during basal and insulin-stimulated steady-state periods. Acipimox reduced NEFA in the basal state and during insulin stimulation. Lipid oxidation was inhibited by Acipimox in all patients in the basal state (20±2 vs. 33±3 mg/m2 per min, P < 0.01) and during insulin infusion (8±2 vs. 17±2 mg/m2 per min, P < 0.01). Acipimox increased the insulin-stimulated glucose disposal rate (369±49 vs. 262±31 mg/m2 per min, P < 0.01), whereas the glucose disposal rate was unaffected by Acipimox in the basal state. Acipimox increased glucose oxidation in the basal state (76±4 vs. 50±4 mg/m2 per min, P < 0.01). During insulin infusion Acipimox increased both glucose oxidation (121±7 vs. 95±4 mg/m2 per min, P < 0.01) and nonoxidative glucose disposal (248±47 vs. 167±29 mg/m2 per min, P < 0.01). Acipimox enhanced basal and insulin-stimulated muscle fractional glycogen synthase activities (32±2 vs. 25±3%, P < 0.05, and 50±5 vs. 41±4%, P < 0.05). Activities of muscle pyruvate dehydrogenase and phosphofructokinase were unaffected by Acipimox. In conclusion, Acipimox acutely improved insulin action in patients with NIDDM by increasing both glucose oxidation and nonoxidative glucose disposal. This supports the hypothesis that elevated NEFA concentrations may be important for the insulin resistance in NIDDM. The mechanism responsible for the increased insulin-stimulated nonoxidative glucose disposal may be a stimulatory effect of Acipimox on glycogen synthase activity in skeletal muscles. (J.

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Section: Resultsmentioning

confidence: 99%

Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus.

Vaag¹,

Skøtt²,

Damsbo³

et al. 1991

J. Clin. Invest.

120

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Section: Nicotinic Acidmentioning

confidence: 99%

Hypolipaemic drugs and coronary heart disease

Howard¹

1975

J Clin Pathol

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“…Attempts to modify the side effects by a change in chemical constitution have not been too successful since the action of the drug is dependent on the free nicotinic acid form. fl-Pyridylcarbinol (Gaut and Taylor, 1968) and pentaerythryl nicotinate (Harthon and Svedmyr, 1974) are claimed to offer some improvement and fewer side effects. NEOMYCIN This antibiotic, which is chiefly unabsorbed in the gastrointestinal tract, is a potent hypocholesterolaemic agent (Samuel, Holtzman, and Goldstein, 1967).…”

Section: D-thyroxinementioning

confidence: 99%

Hypolipaemic drugs and coronary heart disease

Howard¹

1975

Journal of Clinical Pathology

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Effects of Large Doses of Nicotinyl Alcohol on Serum Lipid Levels and Carbohydrate Tolerance

Cited by 3 publications

References 31 publications

Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus.

Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus.

Hypolipaemic drugs and coronary heart disease

Hypolipaemic drugs and coronary heart disease

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