Effects of lawsone methyl ether mouthwash on oral <i><scp>C</scp>andida</i> in <scp>HIV</scp>‐infected subjects and subjects with denture stomatitis

Nittayananta, Wipawee; Pangsomboon, Kanokporn; Panichayupakaranant, Pharkphoom; Chanowanna, Nilnara; Chelae, Sureerat; Vuddhakul, Varaporn; Sukhumungoon, Pharanai; Pruphetkaew, Nannapat

doi:10.1111/jop.12060

Cited by 27 publications

(17 citation statements)

References 34 publications

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“…Increasing resistance of Candida spp. to the generally used antimycotics such as nystatin, fluconazole, miconazole, itraconazole, and ketonazole, constitutes a serious problem in both local and general treatment of patients with diagnosed mycosis (6)(7)(8)(9). The analysis of drug susceptibility of C. albicans and non-Candida albicans strains isolated from the hands of people without any symptoms of disease over a 16-year period in Poland showed increased C. albicans and non-Candida albicans strains resistance to commonly used antifungal chemotherapeutics, mainly imidazole.…”

Section: Discussionmentioning

confidence: 99%

Antifungal drugs resistance profiles of C. albicans strains isolated from the oral cavity of children and adolescents

Kamińska¹,

Malm²,

Szymańska³

2019

Acta Poloniae Pharmaceutica - Drug Research

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Fungi, mainly yeast-like fungi of the Candida genus, and especially the species Candida albicans, occupy an important place among microorganisms that colonize the oral cavity. The aim of this paper was to assess the susceptibility of different strains to some antifungal drugs. The study material consisted of swab samples taken from the buccal mucosa of 376 healthy individuals of both genders, from neonate to18 years. C. albicans strains were isolated in 79 persons. To evaluate drug resistance phenotypes of the isolated C. albicans strains Fungitest TM (Bio-Rad) was used. The study showed that in different age groups the percentage of the tested C. albicans isolates susceptible to all the tested azole drugs varied from 76% to 95%. Drug-resistant strains were found only in the eldest age group (4.8%). Phenotypic diversity (drug resistance types) of the studied isolates indicates a wide range of adaptation possibilities enabling colonization of various ecological niches in the oral cavity ecosystem. The presence of C. albicans strains intermediate or resistant to azole drugs among the tested isolates may be due to the overuse of that drug group in general therapy and the oral cavity treatment.

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Section: Discussionmentioning

confidence: 99%

Antifungal drugs resistance profiles of C. albicans strains isolated from the oral cavity of children and adolescents

Kamińska¹,

Malm²,

Szymańska³

2019

Acta Poloniae Pharmaceutica - Drug Research

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“…In addition, no allergic reaction was reported, and subjects’ satisfaction on taste and smell of LME mouthwash was significantly greater than that of CHX ( P < 0.05) (Sritrairat et al , ). In addition, effects of 0.025% LME mouthwash on antifungal drug resistance and changes in genotypes of oral Candida were determined (Nittayananta et al , ). It has been noted that 0.025% LME mouthwash three times a day for 2 weeks showed neither resistance strains nor changes in genotypes of Candida (Nittayananta et al , ).…”

Section: Herbal Plants With Antifungal Activity: Do They Help?mentioning

confidence: 99%

Oral fungi inHIV: challenges in antifungal therapies

Nittayananta

2016

Oral Diseases

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Oral candidiasis (OC) caused by Candida species is a common fungal infection among HIV‐infected individuals. Despite the wide use of antiretroviral therapy (ART) resulting in a declined prevalence, OC remains the most common oral lesions seen in those living with HIV/AIDS. Various topical and systemic antifungal drugs are available to treat OC. However, due to the patients’ immunodeficiency and the nature of OC as biofilm‐associated infection, relapse is frequently observed after cessation of antifungal therapy. In addition, long‐term antifungal therapy may lead to drug resistance. This review article addressed three major challenges in the treatment of OC in HIV infection including antifungal drug resistance, biofilm‐associated infection of OC, and the host underlying immunodeficiency. To reduce the risks of antifungal drug resistance, the author recommends that future studies should focus on herbal plant‐derived compounds with antifungal activity that may be used in combination with the drugs. Also, it is recommended that more research should be carried out to explore how to enhance the host innate immunity against oral Candida.

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“…Some medicinal plants have been extensively studied in order to find more effective and/ or less toxic compounds. One such example is lawsone methyl ether, a potent antifungal agent from Impatiens balsamina L. (Balsaminaceae) leaves (Sakunphueak & Panichayupakaranant 2010), and has been used in a mouthwash for prophylaxis of oral candidiasis in HIVinfected patients and denture wearers, showed the same efficacy to a chlorhexidine mouthwash and no antifungal drug resistance was observed (Nittayananta et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Bioassay-guided isolation and evaluation of antimicrobial compounds from Ixora megalophylla against some oral pathogens

Panyo

Matsunami

Panichayupakaranant

2016

Pharmaceutical Biology

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Context Ixora megalophylla Chamch. (Rubiaceae) is a new plant species recently found in southern Thailand. Ethyl acetate extracts of its leaves and stems showed antimicrobial activities. Objectives To isolate and identify the antimicrobial compounds from I. megalophylla leaves and stems. Materials and methods The dried leaves (1.7 kg) and stems (3.5 kg) were consecutively extracted with petroleum ether (5 L Â 4), ethyl acetate (5 L Â 3) and ethanol (5 L Â 4) under reflux conditions. The ethyl acetate extract was subjected to an antimicrobial assay guided isolation with Candida albicans and Streptococcus mutans. Compounds 1-10 were identified by 1 H NMR, 13 C NMR and EI-MS. Minimal lethal concentration (MLC) against C. albicans and Streptococcus spp. was determined using a broth microdilution method for 48 and 24 h, respectively. Results and discussion On the basis of the antimicrobial assay guided isolation, 10 known compounds, including vanillic acid (1), syringic acid (2), 4-hydroxy benzaldehyde (3), scopoletin (4), loliolide (5), syringaldehyde (6), sinapaldehyde (7), coniferaldehyde (8), syringaresinol (9) and 2,2 0 -dithiodipyridine (10), were identified. Compounds 1-5 were purified from the ethyl acetate extract of the leaves, while 6-9 and 10 were from the ethyl acetate and ethanol extracts of the stems, respectively. Among these isolates, 10 showed the strongest antibacterial activities against S. mutans and Streptococcus mitis, with minimum inhibitory concentrations (MICs) of 2-4 mg/mL, and MLC of 4 mg/mL, as well as having a weak antifungal activity against C. albicans (MIC of 125 mg/mL). This is the first report of the antimicrobial activities of 10. ARTICLE HISTORY

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Effects of lawsone methyl ether mouthwash on oral Candida in HIV‐infected subjects and subjects with denture stomatitis

Abstract: Use of LME mouthwash for 2 weeks neither led to antifungal drug resistance nor significant changes in genotype of oral Candida. Thus, LME may be an alternative mouthwash in prophylaxis of oral candidiasis among those at risk of developing the disease.

Cited by 27 publications

References 34 publications

Antifungal drugs resistance profiles of C. albicans strains isolated from the oral cavity of children and adolescents

Antifungal drugs resistance profiles of C. albicans strains isolated from the oral cavity of children and adolescents

Oral fungi inHIV: challenges in antifungal therapies

Bioassay-guided isolation and evaluation of antimicrobial compounds from Ixora megalophylla against some oral pathogens

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