Effects of Lead Administration on Developing Rat Kidney

Heavy metal concentrations in female wild mink (Neovison vison) in Sweden: Sources of variation and associations with internal organ weights

“…Environ Toxicol Chem 36, 2017Chem 36, 2033 weight [46,47]. This contrasts with our findings, where mink with high concentrations of Pb had a lower kidney weight.…”

“…A common finding in experimental studies on rats is that Pb seems to cause an increase in kidney weight [43][44][45][46][47]; however, there are also some studies reporting no effect on kidney …”

The Metallothionein-Null Phenotype Is Associated with Heightened Sensitivity to Lead Toxicity and an Inability to Form Inclusion Bodies

“…These data suggest that increases in GST precede cellular and physical changes induced by lead, and thereby provide an extremely sensitive tissue biomarker of lead exposure. 44 Moser and colleagues 45 and Oberley and colleagues 46 have also reported that acute or chronic inorganic lead exposure during development produces cell-type-specific increases in GST expression in the rat kidney. However, whether these increases in GSTs are a result of lead-induced injury or serve as a protective adaptation is not clear.…”

Evaluation of Low Blood Lead Levels and Its Association with Oxidative Stress in Pregnant Anemic Women: A Comparative Prospective Study

“…Pb absorbed by the pregnant mother is readily transferred to the developing fetus [7,8]. There is evidence from animal studies that intrauterine exposure to Pb may disrupt endocrine balance during pregnancy [9,10], and lead to abnormalities of renal structure and function [11], abnormalities of the reproductive system [12], and neurodevelopmental toxicity [13] in offspring. Human evidence corroborates these findings, linking prenatal exposure to Pb with reduced birth weight and preterm delivery [14] and with neurodevelopmental abnormalities in offspring [15,16].…”