Effects of lead exposure on oxidative stress biomarkers and plasma biochemistry in waterbirds in the field

Abstract

and in all common pochards (Aythya ferina) (n ¼ 4), but common coots (Fulica atra) (n ¼ 37) and moorhens (Gallinula chloropus) (n ¼ 12) were all o 20 mg/dl. ALAD ratio in mallards and coots decreased with PbB levels 4 6 mg/dl. In mallards, an inhibition of glutathione peroxidase (GPx) and an increased level of oxidized glutathione (oxGSH) in red blood cells (RBC) were associated with PbB levels 4 20 mg/ dl. In coots, PbB levels were negatively related to vitamin A and carotenoid levels in plasma, and total glutathione in RBCs; and positively related with higher superoxide dismutase and GPx activities and % oxGSH in RBCs. Overall, the results indicate that previously assumed background levels of PbB for birds need to be revised.

Lead Exposure and Oxidative Stress: A Systematic Review

“…These data indicate that lead induces ROS formation due to increased GSSG levels and depletion of GSH levels. Similar results were also obtained in experimental studies (Schwartz et al 2000 ;Martinez-Haro et al 2011 ).…”

“…Lead is an environmental toxicant that can induce oxidative stress (OS) via reactive oxygen species (ROS) generation, which has been reported as an important mechanism underlying lead toxicity (Gurer and Ercal 2000 ;Pande and Flora 2002 ;Kasperczyk et al 2004a ;Farmand et al 2005 ;Verstraeten et al 2008 ;Wang et al 2009 ;Martinez-Haro et al 2011 ). OS occurs when the generation of ROS exceeds the antioxidant system's ability to defend cells against oxidized molecules.…”

Intoxicación por munición de plomo en aves silvestres en España y medidas para reducir el riesgo

“…Por ejemplo, en la Laguna de Medina se ha detectado que el 19 % de los ánades azulones capturados presentaban niveles de plomo en sangre >20 µg/dl, que son indicativos de una posible ingestión de perdigones (Martínez-Haro et al 2011b). En los últimos años, el muestreo no invasivo de heces también ha permitido identificar la frecuencia de ingestión de perdigones de plomo en determinadas especies de aves acuáticas sin la necesidad del trampeo o de muestrear aves abatidas por cazadores (Martínez-Haro et al 2010).…”

Blood oxidative stress and antioxidant defense profile of White Stork Ciconia ciconia chicks reflect the degree of environmental pollution

“…The mechanisms producing the harmful effects of oxidative stress are complex with different biomolecular mechanisms associated with ecotoxicological and ecological aspects (Koivula & Eeva 2010). Components of the antioxidant defense system have the widest scope and greatest potential for use as subcellular biomarkers of the contamination of birds with metals from the environment (Berglund et al 2007(Berglund et al , 2011Hoffman 2002;Hoffman et al 2005Hoffman et al , 2009Hoffman et al , 2011Kamiński et al 2009a;Kurhalyuk et al 2006a, b;Kenow et al 2008;Koivula et al 2011;Martinez-Haro et al 2011;Mateo et al 2003;Mateo & Hoffman 2001).…”

“…Antioxidants and their oxidation products are important indicators of oxidative stress induced by toxic chemicals from environment (Berglund et al 2007(Berglund et al , 2011Hoffman 2002;Hoffman et al 2005Hoffman et al , 2009Hoffman et al , 2011Kamiń-ski et al 2009a, b;Kurhalyuk et al 2006a, b;Kenow et al 2008;Koivula et al 2011;Martinez-Haro et al 2011;Mateo et al 2003;Mateo & Hoffman 2001).…”