Effects of Lens-Care Solutions on Hydrogel Lens Performance

Kitamata-Wong, Britney; Yuen, Tiffany; Li, Wing; Svitova, Tatyana F.; Zhou, Yuquan; Lin, Meng C.

doi:10.1097/opx.0000000000001125

Cited by 9 publications

(14 citation statements)

References 47 publications

(67 reference statements)

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“…These agents could induce toxic and inflammatory responses, including clinical signs of corneal staining, limbal and conjunctival hyperaemia as well as a variety of symptoms [293,294,342,[357][358][359]383,384]. The use of care solutions can cause cytotoxicity, oxidative stress and corneal epithelium disruption [258,345,347,358,370,372,[385][386][387][388]. Additionally, certain MPDS and lens combinations may increase the risk of corneal infiltrative and inflammatory events [46,389].…”

Section: Discussionmentioning

confidence: 99%

“…Using tear interferometry to assess the PLTF, only one MPDS (COMPLETE, Abbott Medical Optics, containing PHMB and poloxamer 237) was able to maintain wettability over the 8 -h lens wear period [103]. Similarly, in a study where a hydrogel contact lens was pre-soaked for six to 14 days in different lens care solutions, tear film stability was increased in vivo with one of the solutions (RevitaLens OcuTec, Johnson & Johnson Vision, containing PQ-1 and alexidine dihydrochloride with tetronic 904), but not with the others (PureMoist or Biotrue) [258]. A study [110] was unable to measure a difference in in vivo wettability after 15 ), compared to saline.…”

Section: Lens Care Solutionsmentioning

confidence: 97%

“…its location being predominantly on the surface or in the bulk of the lens) were partially dependant on whether a surface coating on the lens was present [253]. While several studies report differences in lens wettability or adsorption of wetting agents with different lens care solutions in vitro [254,255], reports are inconsistent on the ability of lens care solutions to maintain contact lens wettability during wear [103,106,110,[256][257][258].…”

Section: Lens Care Solutionsmentioning

confidence: 99%

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BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Willcox

Keir

Maseedupally

et al. 2021

Contact Lens and Anterior Eye

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Contact lens materials have undergone significant changes over the past 20 years, particularly with respect to the introduction of silicone hydrogel materials. Whilst this development addressed hypoxic issues, other important areas relating to contact lens success, notably comfort, require further research.Contact lens wettability remains a crucially important part of biocompatibility. Contact lenses can be made more wettable by incorporation of surfactants into blister packs, internal wetting agents, surface treatments or care solutions. However, there remains no clear association between contact lens wettability and comfort, making it challenging to determine the potential for these approaches to be of significant clinical benefit. Most contact lenses are used on a daily wear, reusable basis, which requires them to be disinfected when not worn. The ideal disinfecting solution would also improve comfort during wear. However, balancing these requirements with other factors, including biocompatibility, remains a challenge. Soft lens materials invariably take up and subsequently release certain components of disinfecting solutions onto the ocular surface. This may affect tear film stability and the normal ocular microbiome, and further research is needed in this area to determine whether this has any affect on comfort. Finally, contact lens materials sorb components of the tear film, and these interactions are complex and may change the biochemistry of the tear film, which in turn may affect their comfort.In conclusion, the interaction between lens materials, tear film and disinfection solution plays an important role in the biocompatibility of lenses. However, the exact role and whether this can be altered to improve biocompatibility and comfort during wear remains debatable. This report summarises the best available evidence to examine this complex relationship and the opportunities for practitioners to enhance in-eye comfort of contemporary lenses, along with providing suggestions for areas of study that may provide further information on this topic.

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Section: Discussionmentioning

confidence: 99%

Section: Lens Care Solutionsmentioning

confidence: 97%

Section: Lens Care Solutionsmentioning

confidence: 99%

See 1 more Smart Citation

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Willcox

Keir

Maseedupally

et al. 2021

Contact Lens and Anterior Eye

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“…Although several studies report no difference in comfort between various multipurpose solutions [393,445,447], those that are PHMB-based have frequently been associated with decreased comfort [448,449] and higher levels of gritty or scratchiness symptoms compared to polyquaternium-based systems [450]. Short-term studies reporting on the comfort of contact lenses pre-soaked in solution [451,452] would have greater relevance if comfort was reported for longer than 2 h of wear.…”

Section: Lens Hygiene and Replacement Frequency-related Risk Factorsmentioning

confidence: 99%

BCLA CLEAR - Contact lens complications

Stapleton

Bakkar

Carnt

et al. 2021

Contact Lens and Anterior Eye

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Contact lens-related complications are common, affecting around one third of wearers, although most are mild and easily managed. Contact lenses have well-defined anatomical and physiological effects on the ocular surface and can result in other consequences due to the presence of a biologically active material. A contact lens interacts with the tear film, ocular surface, skin, endogenous and environmental microorganisms, components of care solutions and other antigens which may result in disease specific to contact lens wear, such as metabolic or hypersensitivity disorders. Contact lens wear may also modify the epidemiology or pathophysiology of recognised conditions, such as papillary conjunctivitis or microbial keratitis. Wearers may also present with intercurrent disease, meaning concomitant or pre-existing conditions unrelated to contact lens wear, such as allergic eye disease or blepharitis, which may complicate the diagnosis and management of contact lens-related disease.Complications can be grouped into corneal infection (microbial keratitis), corneal inflammation (sterile keratitis), metabolic conditions (epithelial: microcysts, vacuoles, bullae, tight lens syndrome, epithelial oedema; stromal: superficial and deep neovascularisation, stromal oedema [striae/folds], endothelial: blebs, polymegethism/ pleomorphism), mechanical (corneal abrasion, corneal erosion, lens binding, warpage/refractive error changes; superior epithelial arcuate lesion, mucin balls, conjunctival epithelial flaps, ptosis, discomfort), toxic and allergic disorders (papillary conjunctivitis, solution-induced corneal staining, incomplete neutralisation of peroxide, Limbal Stem Cell Deficiency), tear resurfacing disorders/dry eye (contact lens-induced dry eye, Meibomian gland dysfunction, lid wiper epitheliopathy, lid parallel conjunctival folds, inferior closure stain, 3 and 9 o'clock stain, dellen, dimple veil) or contact lens discomfort. This report summarises the best available evidence for the classification, epidemiology, pathophysiology, management and prevention of contact lensrelated complications in addition to presenting strategies for optimising contact lens wear.

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“…9 LWE formation has also been attributed to lid pressure, tear composition, tear viscosity, surface texture, and blink velocity. [3][4][5]10 As contact lens wear is associated with increased tear film instability, 11 it may explain why LWE may occur more frequently among contact lens wearers, possibly more so in contact lenses with a higher coefficient of friction. 10,12 It has been hypothesized that the subsequent irregularities in the lid wiper region can lead to greater friction during blinks, which translates to a corresponding increase in ocular discomfort and dryness.…”

mentioning

confidence: 99%

The Relationship of Lid Wiper Epitheliopathy to Ocular Surface Signs and Symptoms

Yeh

Leung

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. There has been interest in determining whether lid wiper epitheliopathy (LWE) plays a key role in causing ocular discomfort. Conflicting reports have made it difficult to discern whether LWE is more prevalent in certain populations, what characteristics are associated with its severity, and what its role is in symptomology. This cross-sectional study on a large and diverse population attempts to answer these questions.METHODS. Subjects were asked to complete questionnaires related to dry eye and to ocular discomfort. A comprehensive set of ocular surface parameters were assessed, including LWE length and width, tear-film lipid layer thickness, fluorescein tear breakup time (FTBUT), lidparallel conjunctival folds (LIPCOF), and corneal staining. RESULTS.A total of 287 subjects participated in the study. LWE was observed in 45% of the study cohort and was twice as prevalent in Asians than non-Asians (P < 0.005). LWE was more likely to present in contact lens wearers than non-contact lens wearers (P ¼ 0.03). Decreased FTBUT was associated with increased LWE length and width (P < 0.005 and P ¼ 0.01, respectively), although only a small effect size was noted. Presence of LIPCOF was linked with a 0.25-grade increase in LWE width (P ¼ 0.01). Only LWE width was associated with greater symptoms in contact lens wearers.CONCLUSIONS. LWE was associated with decreased tear-film stability, contact lens wear, lid anatomy, and LIPCOF. LWE was not associated with symptoms in non-contact lens wearers. LWE width was associated with greater symptoms in contact lens wearers but was only clinically significant with moderate to severe LWE width.

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Effects of Lens-Care Solutions on Hydrogel Lens Performance

Cited by 9 publications

References 47 publications

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

BCLA CLEAR - Contact lens complications

The Relationship of Lid Wiper Epitheliopathy to Ocular Surface Signs and Symptoms

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