Effects of Lesions and Electrical Stimulation of the Amygdala on Hypothalamic-Hypophyseal-Regulation

Zolovick, A.J.

doi:10.1007/978-1-4615-8987-7_25

Cited by 49 publications

(30 citation statements)

References 94 publications

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“…The hypothalamus integrates activity of the ANS and neuroendocrine system (Fuchs et al, 1985;Swaab, 2004). Central amygdala connects reciprocally with PVN, VMN, and PPN, modulates pituitary hormone secretion and reproductive functions (Zolovick, 1972), and is involved in aggression and the stress response. The amygdala and hypothalamus project to the brainstem, thus giving limbic system input to the control of the ANS (Armony and LeDoux, 2000).…”

Section: Discussionmentioning

confidence: 99%

Hormonal Cycle Modulates Arousal Circuitry in Women Using Functional Magnetic Resonance Imaging

Goldstein¹,

Jerram²,

Poldrack³

et al. 2005

J. Neurosci.

323

254

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Sex-specific behaviors are in part based on hormonal regulation of brain physiology. This functional magnetic resonance imaging (fMRI) study demonstrated significant differences in activation of hypothalamic-pituitary-adrenal (HPA) circuitry in adult women with attenuation during ovulation and increased activation during early follicular phase. Twelve normal premenopausal women were scanned twice during the early follicular menstrual cycle phase compared with late follicular/midcycle, using negative valence/high arousal versus neutral visual stimuli, validated by concomitant electrodermal activity (EDA). Significantly greater magnitude of blood oxygenation level-dependent signal changes were found during early follicular compared with midcycle timing in central amygdala, paraventricular and ventromedial hypothalamic nuclei, hippocampus, orbitofrontal cortex (OFC), anterior cingulate gyrus (aCING), and peripeduncular nucleus of the brainstem, a network of regions implicated in the stress response. Arousal (EDA) correlated positively with brain activity in amygdala, OFC, and aCING during midcycle but not in early follicular, suggesting less cortical control of amygdala during early follicular, when arousal was increased. This is the first evidence suggesting that estrogen may likely attenuate arousal in women via cortical-subcortical control within HPA circuitry. Findings have important implications for normal sex-specific physiological functioning and may contribute to understanding higher rates of mood and anxiety disorders in women and differential sensitivity to trauma than men.

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Section: Discussionmentioning

confidence: 99%

Hormonal Cycle Modulates Arousal Circuitry in Women Using Functional Magnetic Resonance Imaging

Goldstein¹,

Jerram²,

Poldrack³

et al. 2005

J. Neurosci.

323

254

View full text Add to dashboard Cite

show abstract

“…Transection of the stria blocks this ovulatory response, whereas lesion of the ventral amygdalofugal pathway does not (26). Bilateral ablation of the basolateral amygdala in adult female deermice can induce anovulatory cycles and the accumulation of small ovarian cysts, which are reminiscent of PCOS (27). Stimulation of the corticomedial amygdala increases gonadotropin secre- and PMV that are involved in reproductive and reproductive endocrine functions supports this hypothesis.…”

Section: Discussionmentioning

confidence: 78%

Lateral Asymmetry in Activation of Hypothalamic Neurons with Unilateral Amygdaloid Seizures

et al. 2000

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Summary:Purpose: Reproductive disorders are unusually frequent among women with temporal lobe seizures. The particular type of disorder may be related to the laterality and focality of epileptiform discharges. Here we examined whether unilateral amygdaloid seizures activate hypothalamic neurons involved in reproductive function and reproductive endocrine secretion in female rats and whether such activation shows lateral asymmetry.Methods: Numbers of Fos-immunoreactive (Fos-ir) neurons in various hypothalamic regions were compared for three groups of animals: (a) unilateral amygdala-kindled, (b) implanted but unstimulated, and (c) unimplanted.Results: Fos-ir neurons showed strong ipsilateral occurrence in the medial preoptic, ventrolateral part of the ventromedial, and ventral premammillary nuclei, sexually dimorphic regions involved i n reproductive endocrine regulation. No significant lateral asymmetry was observed for other investigated hypothalamic regions.Conclusions: Unilateral amygdaloid seizures activate hypothalamic neurons that regulate reproductive endocrine secretion in a laterally asymmetric fashion. This may explain the clinical association of different reproductive endocrine disorders with left and right temporal epileptiform discharges.

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“…Калимуллиной (1993) [1] убедительно показано наличие в миндалевидном комплексе (МК) зон по-лового диморфизма, реагирующих на изменения концентрации гормонов. Данные о причастности МК к нейроэндокринным структурам, вовлеченным в регуляцию процессов размножения, появились в начале 50-х годов прошлого столетия [12]. В начале 70-х годов была выявлена способность нейронов МК связывать половые стероиды, и появились осно-вания говорить о существовании в них специфиче-ских рецепторов [5,11].…”

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“…Исследованиями ряда авторов уста-новлено, что уровень молочной продуктивности, качество продукции, воспроизводительная способ-ность и продолжительность хозяйственного исполь-зования коров определяется, в первую очередь, уровнем их кормления, качеством кормов и струк-турой сбалансированных по питательным веще-ствам рационов [1-3, 5, 8, 9]. В достижении высоко-го уровня биологической полноценности кормления животных в последние годы стали широко исполь-зовать различные кормовые добавки, позволяющие сбалансировать рационы по биологически активным веществам [1][2][3][4][5][6][7][8][9][10][11][12]. В связи с этим использование комплексной кормовой добавки «Биодарин» в раци-онах молочных коров черно-пестрой породы в каче-стве катализатора обменных процессов в организме, а также изучение её влияния на молочную продук-тивность и на технологические свойства молока и молочных продуктов является актуальным и имеет научно-практическое значение.…”

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THE ANALYSIS OF ULTRASTRUCTURAL PECULIARITIES OF NEURONS OF AMYGDALA’S ANTERIOR CORTICAL NUCLEUS IN THE BRAIN OF WAG/Rij RATS DEPENDING ON THE SEX

Garipova¹,

Хисматуллина²

2016

VESTNIK BSAU

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Effects of Lesions and Electrical Stimulation of the Amygdala on Hypothalamic-Hypophyseal-Regulation

Cited by 49 publications

References 94 publications

Hormonal Cycle Modulates Arousal Circuitry in Women Using Functional Magnetic Resonance Imaging

Hormonal Cycle Modulates Arousal Circuitry in Women Using Functional Magnetic Resonance Imaging

Lateral Asymmetry in Activation of Hypothalamic Neurons with Unilateral Amygdaloid Seizures

THE ANALYSIS OF ULTRASTRUCTURAL PECULIARITIES OF NEURONS OF AMYGDALA’S ANTERIOR CORTICAL NUCLEUS IN THE BRAIN OF WAG/Rij RATS DEPENDING ON THE SEX

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