Effects of Lespedeza cuneate Extracts on Andropause Symptoms and Testosterone Metabolism in Aged Rats

Byun, Jae-Hyuk; Choung, Se‐Young

doi:10.17480/psk.2019.63.6.359

Yakhak Hoeji

2019

DOI: 10.17480/psk.2019.63.6.359

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Effects of Lespedeza cuneate Extracts on Andropause Symptoms and Testosterone Metabolism in Aged Rats

Jae-Hyuk Byun¹,

Se‐Young Choung²

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Effects of elephant garlic (Allium ampeloprasum) extract on testosterone synthesis in TM3 Leydig cells

Park¹,

Lee²,

Jeong³

et al. 2022

Korean J. Food Preserv.

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This work investigated the effects of Allium ampeloprasum extract (AME) on testosterone synthesis in TM3 Leydig cells under hydrogen peroxide (H2O2)-induced oxidative stress. AME showed no increment of cell proliferation in the oxidatively stressed cells. Testosterone level lowered when the cells were treated with H2O2, but increased in the presence of AME. To determine the effect of AME on the testosterone biosynthetic pathway, we examined the expression level of the proteins involved in the synthesis or degradation of testosterone. The protein expression levels of CYP11A1, 3β-HSD2 and 17β-HSD3 (which are involved in testosterone synthesis) were decreased by H2O2 but increased by the AME treatment. Furthermore, the protein expression levels of 5α-reductase2 and aromatase (which are involved in testosterone degradation) were increased by H2O2 but decreased by the AME treatment. In conclusion, AME increased the testosterone level by increasing the expression of testosterone synthetase and decreasing the expression of the testosterone converting enzyme in TM3 Leydig cells under H2O2-induced oxidative stress. These results indicated that AME can alleviate andropause syndrome by restoring testosterone.

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Effects of elephant garlic (Allium ampeloprasum) extract on testosterone synthesis in TM3 Leydig cells

Park¹,

Lee²,

Jeong³

et al. 2022

Korean J. Food Preserv.

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Improvement of Late-Onset Hypogonadism Symptoms of Fermented Morinda citrifolia Extract in TM3 Leydig and TM4 Sertoli Cells

Kwon,

Lee,

Choi

et al. 2024

Nutrients

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Background/Objectives: Late-onset hypogonadism (LOH), characterized by declining testosterone levels with age, negatively affects the health of men, causing physical, psychological, and sexual dysfunction. Conventional testosterone replacement therapies have side effects, which has led to interest in natural alternatives. We investigated the effects of a standardized fermented Morinda citrifolia extract (FME) on oxidative stress-induced damage in TM3 Leydig and TM4 Sertoli cells. The cells were treated with H2O2 to simulate oxidative stress, followed by the FME treatment. Methods: Cytotoxicity assays, testosterone measurements, and gene and protein expression analyses were conducted to evaluate the restorative properties of FME. Results: The H2O2 treatment significantly decreased the cell viability, testosterone production, and the expression of proteins involved in testosterone synthesis and spermatogenesis, and the FME treatment improved testosterone production and restored the luteinizing hormone receptor, steroidogenic acute regulatory protein, CYP11A1, 3β-hydroxysteroid dehydrogenase, 17,20 desmolase, and 17β-hydroxysteroid dehydrogenase levels in the TM3 Leydig cells. It also reduced the expression of testosterone-degrading enzymes, aromatase and 5α-reductase. The FME treatment restored the levels of the androgen receptor and follicle-stimulating hormone receptor in the TM4 Sertoli cells. Conclusions: FME alleviates oxidative stress-induced damage in Leydig and Sertoli cells by promoting testosterone synthesis and spermatogenesis while regulating testosterone metabolism. These findings suggest that FME could be a promising candidate for the management of LOH symptoms.

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Effects of Lespedeza cuneate Extracts on Andropause Symptoms and Testosterone Metabolism in Aged Rats

Cited by 2 publications

References 0 publications

Effects of elephant garlic (Allium ampeloprasum) extract on testosterone synthesis in TM3 Leydig cells

Effects of elephant garlic (Allium ampeloprasum) extract on testosterone synthesis in TM3 Leydig cells

Improvement of Late-Onset Hypogonadism Symptoms of Fermented Morinda citrifolia Extract in TM3 Leydig and TM4 Sertoli Cells

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