2008
DOI: 10.1111/j.1528-1167.2007.01523.x
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Effects of levetiracetam on EEG abnormalities in juvenile myoclonic epilepsy

Abstract: Juvenile myoclonic epilepsy (JME) is a genetically determined epilepsy syndrome. It presents with myoclonic

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Cited by 57 publications
(43 citation statements)
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“…Moreover, 45% of the patients had become seizure free for almost 7 months to 1 year with normalization of EEG in 80% of these patients. This finding is consistent with a previous study which revealed that LEV appeared to be effective in decreasing epileptiform EEG abnormalities (Specchio et al, 2008). Most of the seizure types were found to be of tonic-clonic type.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…Moreover, 45% of the patients had become seizure free for almost 7 months to 1 year with normalization of EEG in 80% of these patients. This finding is consistent with a previous study which revealed that LEV appeared to be effective in decreasing epileptiform EEG abnormalities (Specchio et al, 2008). Most of the seizure types were found to be of tonic-clonic type.…”
Section: Discussionsupporting
confidence: 93%
“…At 12-month evaluation: 29 patients were seizure free; three patients were responders with no reported adverse events. Moreover, Specchio et al (2008) supports a first-line role for LEV in the treatment of JME. Consistently, Stephen et al (2011) found that seizure freedom was achieved in around half adult patients on a median LEV dose of 1000 mg/day.…”
Section: Discussionmentioning
confidence: 82%
“…No patients reported adverse events. These results were confirmed in a pilot trial by Specchio et al, [47] who also investigated the correlation between levetiracetam-related EEG changes and clinical outcome. Efficacy parameters were based on the comparison and analysis of EEG interictal abnormalities classified as spikesand-waves, polyspikes-and-waves, and the presence of a photoparoxysmal response (PPR).…”
Section: Juvenile Myoclonic Epilepsysupporting
confidence: 68%
“…In addition, a study reported the efficacy of LEV in GGE with MS . Some studies also reported a good efficacy and tolerability profile for LEV in the treatment of JME . Above all, LEV may be a better option for women with JME in view of the side effects of VPA.…”
Section: Discussionmentioning
confidence: 99%