Effects of Levobupivacaine on Wound Healing

Zeren, Sezgin; Kesi̇ci̇, Sevgi; Kesici, Uğur; Isbilir, Salim; Türkmen, Ülkü Aygen; Ulusoy, Hülya; Karpuz, Vildan; Özcan, Ömer; Polat, Erdal; İpçioğlu, Osman Metin; Sari, Musa K.

doi:10.1213/ane.0b013e318273f48e

Cited by 24 publications

(27 citation statements)

References 13 publications

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“…Also Nykanen et al concluded that eutectic mixture of lidocaine/prilocaine cream does not affect wound healing adversely and is comparable to 1% lidocaine infiltration in a single blind prospective rat model . Zeren et al reported that levobupivacaine impairs wound healing during the early period and has positive effect during later periods of wound healing . Feder et al showed that lidocaine, bupivacaine and ropivacaine had concentration‐dependent cytotoxic effect on fibroblasts .…”

Section: Discussionsupporting

confidence: 83%

Comparison of the effects of gabapentin and pregabalin on wound healing in rats

Sarıtaş

Korkmaz

Sevımlı

et al. 2014

International Wound Journal

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Gabapentinoids are effective adjunct drugs for reducing postoperative pain. However, the effects of gabapentinoids on wound healing have not been evaluated yet. In this study we evaluated their effects on wound healing. A total of 17 male Wistar-Albino rats, 250-350 g, were divided into three groups randomly: control group (n = 5, 2 ml saline), gabapentin group (n = 6, 20 mg/kg gabapentin) and pregabalin group (n = 6, 20 mg/kg pregabalin). Until day 13 inflammation scores were significantly lower (P < 0·05) and wound healing was significantly better in the control group when compared with gabapentin and pregabalin groups (P < 0·001). Inflammation scores were significantly lower in pregabalin group when compared with gabapentin group until day 13. But wound healing was significantly better in gabapentin group than in pregabalin group between days 13 and 21. In conclusion when gabapentin and pregabalin were compared, although pregabalin decreases inflammation scores, gabapentin has better results in wound healing.

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Section: Discussionsupporting

confidence: 83%

Comparison of the effects of gabapentin and pregabalin on wound healing in rats

Sarıtaş

Korkmaz

Sevımlı

et al. 2014

International Wound Journal

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“…It also increased the inflammatory response and collagen synthesis on both the 8 th and 21 st days. [39]…”

Section: Clinical Utilitymentioning

confidence: 99%

Clinical profile of levobupivacaine in regional anesthesia: A systematic review

Bajwa

Kaur

2013

J Anaesthesiol Clin Pharmacol

108

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The quest for searching newer and safer anesthetic agents has always been one of the primary needs in anesthesiology practice. Levobupivacaine, the pure S (−)-enantiomer of bupivacaine, has strongly emerged as a safer alternative for regional anesthesia than its racemic sibling, bupivacaine. Levobupivacaine has been found to be equally efficacious as bupivacaine, but with a superior pharmacokinetic profile. Clinically, levobupivacaine has been observed to be well-tolerated in regional anesthesia techniques both after bolus administration and continuous post-operative infusion. The incidence of adverse drug reactions (ADRs) is rare when it is administered correctly. Most ADRs are related to faulty administration technique (resulting in systemic exposure) or pharmacological effects of anesthesia; however, allergic reactions can also occur rarely. The available literary evidence in anesthesia practice indicates that levobupivacaine and bupivacaine produce comparable surgical sensory block, similar adverse side effects and provision of similar labor analgesia with good comparable maternal and fetal outcome. The present review aims to discuss the pharmacokinetic and pharmacological essentials of the safer profile of levobupivacaine as well as to discuss the scope and indications of levobupivacaine based on current clinical evidence.

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“…After the introduction of cocaine to the medical practice, local anaesthetics (LAs) became essential in pain control . LA infiltration along the incision may be used to provide surgical anaesthesia or postoperative analgesia . The most frequently used LAs for these purposes are lidocaine and bupivacaine .…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial effects of local anaesthetics

Kesici

Demırci

Kesi̇ci̇

2019

International Wound Journal

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After the introduction of cocaine to the medical practice, local anaesthetics (LA) became essential in pain control. LA infiltration along the incision may be used to provide surgical anaesthesia or postoperative analgesia. This study aimed to compare the antimicrobial effects of the topical antimicrobial agent mupirocine with those of the LA lidocaine and the combination of lidocaine and adrenalin. In our study, the in vitro antimicrobial effects of 1 mL sterile saline, 20 mg/mL mupirocine, 20 mg/mL Lidocaine, and 20 mg/mL Lidocaine and Adrenaline were tested against Staphylococcus aureus American type culture collection (ATCC) 29213, Pseudomonas aeruginosa ATCC 27853, and Escherichia coli ATCC 25922 as Group C (Control), Group M (Mupirocine), Group L (Lidocaine), and Group LA (Lidocaine + adrenaline), respectively. S aureus ATCC 29213, P aeruginosa ATCC 27853, and E coli ATCC 25922 were cultured onto Mueller–Hinton agar (Oxoid, UK) plates for 18 to 24 hours at 37°C. Colonies from these plates were suspended in sterile saline and a 0.5 McFarland turbidity standard suspension (corresponding to 1.5 × 108 CFU/mL) of each isolate was prepared. S Aureus ATCC 29213 inhibition zone diameter values of Group M, Group LA, and Group L were significantly higher compared with the group C (P ˂ 0.05). P aeruginosa ATCC 27853 inhibition zone diameter values of Group M and Group LA were significantly higher compared with the group C (P ˂ 0.05). E coli ATCC 25922 inhibition zone diameter values of Group M, Group LA, and Group L were significantly higher compared to the group C (P ˂ 0.05). LA infiltration along the incision may be used to provide surgical anaesthesia or postoperative analgesia. Considering that LAs show antimicrobial effects besides their analgesic effects, they may contribute to preventing the development and reducing the rate of surgical infections, decreasing the requirement to administer antibiotics. However, caution should be exercised not to antagonise the effective treatment of surgical infections, remembering that controversy on the antimicrobial effects of LAs remains in the literature. Therefore, further comprehensive studies with larger patient populations are warranted to demonstrate the antimicrobial effects of LAs.

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Effects of Levobupivacaine on Wound Healing

Abstract: While levobupivacaine had a positive effect on wound healing during the early period, negative effects were observed thereafter. Additional studies at the molecular level are necessary to determine the cause of these apparently opposite effects.

Cited by 24 publications

References 13 publications

Comparison of the effects of gabapentin and pregabalin on wound healing in rats

Comparison of the effects of gabapentin and pregabalin on wound healing in rats

Clinical profile of levobupivacaine in regional anesthesia: A systematic review

Antimicrobial effects of local anaesthetics

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