Effects of Levonorgestrel-Releasing Intrauterine Device Therapy on Ovarian Reserve in Menorrhagia

Abstract

This study aimed to investigate the effects of levonorgestrel-releasing intrauterine device (LNG-IUD) treatment on ovarian reserve in women of reproductive age diagnosed with menorrhagia. MethodsThis was a prospective controlled trial involving 50 women with menorrhagia and a control group comprising age-matched 50 healthy women. Women who satisfied the LNG group criteria underwent an endometrial pipelle biopsy and LNG-IUD insertion. Ovarian reserve tests were performed prior to and six months after LNG-IUD insertion in the LNG group cases. ResultsFollicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), anti-Müllerian hormone (AMH), endometrial thickness (ET), total antral follicle count (AFC), and mean ovarian volume values before LNG-IUD insertion did not differ between the LNG and control groups. When the final measurements were compared, FSH, AMH, total AFC, and average ovarian volume increased (p=0.05, 0.046, 0.022, and 0.022, respectively), E2 and ET decreased (p=0.034 and 0.001, respectively) in the LNG group, while LH did not differ significantly between the groups (p=0.71). ConclusionWe observed that LNG-IUD use effectively improves fertility capacity. In this study, LNG-IUD use in reproductive-age women diagnosed with menorrhagia decreased E2 levels, did not change LH levels, and increased FSH, AFC, and AMH levels.

Comparison of Safety and Efficacy of Oral Progesterone With Levonorgestrel Intrauterine System in Management of Dysfunctional Uterine Bleeding

“…LNG-IUS is considered the first-line protocol for managing menorrhagia (Cooper et al, 2019). Various studies have reported the superiority of progesterone-releasing intrauterine devices over conventional treatments for dysfunctional uterine bleeding (Gök et al, 2022;Joo et al, 2021;Kumari et al, 2022;Momoeda et al, 2022). However, local data on cost effectiveness and outcomes of LNG-IUS and conventional treatments are scarce.…”