Effects of lifestyle changes on adults with prediabetes: A systematic review and meta-analysis

Glechner, Anna; Keuchel, Lina; Affengruber, Lisa; Titscher, Viktoria; Sommer, Isolde; Matyas, Nina; Wagner, Gernot; Kien, Christina; Klerings, Irma; Gartlehner, Gerald

doi:10.1016/j.pcd.2018.07.003

Cited by 156 publications

(109 citation statements)

References 79 publications

(282 reference statements)

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“…Focusing on the group restricted to adults with prediabetes, it is not clear why they do not seem to reap any benefits from meeting MVPA or having lower levels of sedentary behavior. It is possible that individuals with prediabetes who maintained a high level of MVPA at V1 and at V2, may have slowed their progression to diabetes [37].…”

Section: Discussionmentioning

confidence: 99%

Are sedentary behavior and physical activity independently associated with cardiometabolic benefits? The Hispanic Community Health Study/Study of Latinos

Mossavar‐Rahmani

Hua

et al. 2020

BMC Public Health

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Background Whether physical activity can reduce cardiometabolic risk particularly in understudied populations such as US Hispanics/Latinos is of public health interest. We prospectively examined the association of physical activity and cardiometabolic biomarkers in n = 8049 participants of the Hispanic Community Health Study/Study of Latinos, a community-based cohort study of 16,415 adults aged 18–74 yr who self-identified as Hispanic/Latino from four US urban centers. Methods We assessed physical activity using accelerometry in 2008–2011 at visit 1. We assessed cardiometabolic biomarkers twice: once at visit 1 and collected a second measure in 2014–2017 at visit 2. We used survey linear regression models with changes in cardiometabolic markers as the dependent variables and quartiles of sedentary behavior or whether adults met guidelines for moderate-to-vigorous physical activity as the independent variables. Results In normoglycemic adults without cardiovascular disease, but not in adults with evidence of cardiometabolic disease, those who were in the lowest quartile for sedentary behavior (< 10.08 h/day) had a significant decline in mean LDL-cholesterol of − 3.94 mg/dL (95% CI: − 6.37, − 1.52) compared to adults in the highest quartile (≥13.0 h/day) who exhibited a significant increase in LDL-cholesterol of 0.14 mg/dL (95% CI, − 2.15,2.42) over the six year period (P < 0.02 in fully adjusted models.) There was also a trend toward lower mean increase in HbA1c comparing the lowest with the highest quartile of sedentary behavior. Overall regardless of glycemic level or evidence of cardiometabolic disease, adults who met guidelines for moderate-to-vigorous physical activity at visit 1, had significantly lower mean increases in level of fasting glucose compared to adults not meeting guidelines in fully adjusted models. Conclusions In this cohort of Hispanics/Latinos, being free of cardiometabolic disease and having low levels of sedentary behavior were associated with health benefits. Among all adults regardless of cardiometabolic disease, meeting guidelines for moderate-to-vigorous physical activity was associated with health benefits. Overall these data suggest that an active lifestyle may blunt the association of advancing age with worsening cardiometabolic risk factors.

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Section: Discussionmentioning

confidence: 99%

Are sedentary behavior and physical activity independently associated with cardiometabolic benefits? The Hispanic Community Health Study/Study of Latinos

Mossavar‐Rahmani

Hua

et al. 2020

BMC Public Health

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“…Early identification of this condition provides a window of opportunity to alter the natural history of T2DM. Several DM prevention programs have identified lifestyle interventions that potentially provide sustained benefits for many years, with a lower rate of progression from pre-diabetes to T2DM [52]. Our estimate identified 47.3% of the screen-positive dental patients were identified as pre-diabetic with the reference standard.…”

Section: Poc Screening Test Outcomementioning

confidence: 80%

Prevalence of undiagnosed diabetes and pre-diabetes in the dental setting: A Systematic review and meta-analysis

Chinnasamy

Moodie

2020

Preprint

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Background With the close link between Diabetes Mellitus (DM)and periodontal disease dentists have an unrealized opportunity to make a chance discovery of a patient’s medical condition. Unlike in the medical setting, information on the Point-of-Care (PoC), opportunistic screening for DM in the dental setting is limited. To make a reliable estimate on the prevalence of undiagnosed type 2 diabetes mellitus (T2DM) and prediabetes among dental patients in the dental setting and to assist healthcare planners in making an informed decision, information on the disease frequency and strategies employed to address this issue are of paramount importance . As such, the objectives of this study is to summarize the data on the prevalence of undiagnosed T2DM and pre-diabetes amongst dental patients and further explore the effectiveness of the PoC screening and its implication for use in the dental setting. Methods A MEDLINE – PubMed, EMBASE, Web of Science and Cochrane library search was conducted with no time specification. Information on study characteristics and diagnostic parameters were retrieved for metaanalysis. All the studies were assessed for methodological quality using the QUADAS 2 tool. Proportions were presented in tables and Forrest plots. All statistical analysis was performed using the Medcalc software. Results Nine studies met the inclusion criteria. The proportion of dental patients identified to be at risk of hyperglycaemia with the PoC screening using random blood glucose, and glycated haemoglobin was 32.47% and 40.10%, whilst the estimated proportion with undiagnosed T2DM and pre-diabetes was identified as 11.23% and 47.38%. Conclusion A significant proportion of dental patient can be identified as undiagnosed T2DM and prediabetes. Targeted opportunistic screening is a feasible approach and can help reduce the prevalence of undiagnosed T2DM and pre-diabetes.

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“…5 If more clinicians recognised the presenting symptoms of gastrointestinal dysmotility and absence of tears in infancy as potentially associated with multiple endocrine neoplasia type 2B, more children could undergo age-appropriate thyroidectomy, which has been shown to improve survival in hereditary medullary thyroid cancer. 6 First-line treatment for phaeochromocytoma in patients with multiple endocrine neoplasia type 2B is adrenalectomy. Historically, this procedure has been total adrenalectomy although recent surgical advances have led to the increasing use of adrenalsparing procedures; before this study, outcomes of adrenal-sparing surgery had not been reported specifically in multiple endocrine neoplasia type 2B.…”

Section: Careful Investigation Of a Rare Disease: Insights Into Multimentioning

confidence: 99%

“…First, lifestyle interventions within their current form (ie, increasing physical activity, healthy dietary habits, and weight loss) can reduce the progression to diabetes in people with IGT. 6 However, such interventions do not appear to reduce diabetes incidence in those with IFG, [7][8][9] which is different in terms of pathophysiology from IGT. 10…”

mentioning

confidence: 99%

Diabetes prevention and lifestyle intervention in resource-limited settings

Sathish

2019

The Lancet Diabetes & Endocrinology

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Effects of lifestyle changes on adults with prediabetes: A systematic review and meta-analysis

Cited by 156 publications

References 79 publications

Are sedentary behavior and physical activity independently associated with cardiometabolic benefits? The Hispanic Community Health Study/Study of Latinos

Are sedentary behavior and physical activity independently associated with cardiometabolic benefits? The Hispanic Community Health Study/Study of Latinos

Prevalence of undiagnosed diabetes and pre-diabetes in the dental setting: A Systematic review and meta-analysis

Diabetes prevention and lifestyle intervention in resource-limited settings

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