Effects of lifestyle intervention on left ventricular regional myocardial function in metabolic syndrome patients from the RESOLVE randomized trial

Serrano-Ferrer, Juan; Crendal, Edward; Walther, Guillaume; Vinet, Agnès; Dutheil, Frédéric; Naughton, Géraldine; Lesourd, B.; Chapier, Robert; Courteix, Daniel; Obert, Philippe

doi:10.1016/j.metabol.2016.05.006

Cited by 24 publications

(21 citation statements)

References 37 publications

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“…This study is a secondary analysis of the RESOLVE randomized controlled trial [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ], where participants were randomly assigned into three groups of different intensities of exercise (same volume/time of training between groups): 1) Re group—high-resistance-moderate-endurance, participants performed 10 repetitions at 70% of one maximal repetition in resistance and 30% of VO2-max for endurance training, 2) rE group—moderate-resistance (30%)-high-endurance (70%), and 3) re group—moderate-resistance (30%)-moderate-endurance (30%). Randomization was computer generated with stratification according to sex, age, and body mass index.…”

Section: Methodsmentioning

confidence: 99%

Dietary Fibres and the Management of Obesity and Metabolic Syndrome: The RESOLVE Study

Tremblay

Clinchamps²,

Pereira³

et al. 2020

Nutrients

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Objectives: This study was performed to evaluate the long-term maintenance of nutritional changes promoted during an intensive initial intervention to induce body weight loss. The ability of these changes to predict long-term health outcomes was also examined. Methods: Nutritional variables, body composition, and metabolic markers collected in the RESOLVE project were analyzed before and after a 3-week intensive diet–exercise intervention (Phase 1), and during a subsequent supervision under free living conditions, of 12 months (Phase 2). Results: As expected, the macronutrient composition of the diet was modified to promote a negative energy balance during Phase 1. The decrease in carbohydrates imposed during this phase was maintained during Phase 2 whereas the increase in protein intake returned to baseline values at the end of the program. Dietary fiber intake was almost doubled during Phase 1 and remained significantly greater than baseline values throughout Phase 2. Moreover, fiber intake was the only nutritional variable that systematically and significantly predicted variations of health outcomes in the study. Conclusion: The adequacy of dietary fiber intake should be a matter of primary consideration in diet-based weight reduction programs.

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Section: Methodsmentioning

confidence: 99%

Dietary Fibres and the Management of Obesity and Metabolic Syndrome: The RESOLVE Study

Tremblay

Clinchamps²,

Pereira³

et al. 2020

Nutrients

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“…90,91 TNF-a was also linked with impaired left ventricular regional myocardial function. 92,93 IL-6 triggers an increase in fibrinogens and the number and activity of platelets, leading to increased risk of clot formation. 94 Additionally, vascular endothelial and smooth muscle cells are also targets of the IL-6 adipokine.…”

Section: Vat Low-grade Chronic Inflammation and Adipokinesmentioning

confidence: 99%

Cardiovascular risk of adipokines: a review

et al. 2017

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Over the last two decades, the understanding of adipose tissue has undergone radical change. The perception has evolved from an inert energy storage tissue to that of an active endocrine organ. Adipose tissue releases a cluster of active molecules named adipokines. The severity of obesity-related diseases does not necessarily correlate with the extent of body fat accumulation but is closely related to body fat distribution, particularly to visceral localization. There is a distinction between the metabolic function of central obesity (visceral abdominal) and peripheral obesity (subcutaneous) in the production of adipokines. Visceral fat accumulation, linked with levels of some adipokines, induces chronic inflammation and metabolic disorders, including glucose intolerance, hyperlipidaemia, and arterial hypertension. Together, these conditions contribute to a diagnosis of metabolic syndrome, directly associated with the onset of cardiovascular disease. If it is well known that adipokines contribute to the inflammatory profile and appetite regulation, this review is novel in synthesising the current state of knowledge of the role of visceral adipose tissue and its secretion of adipokines in cardiovascular risk.

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“… 27 The reduction in EAT was associated with an improvement in the left ventricular regional myocardial function in patients with metabolic syndrome. 28 Even though there is some evidence, the magnitude of effect of aerobic exercise on EEATT has not been well characterized in a large sample-based study so far. The objective of our study was to determine the effect of aerobic exercise program on the EEATT, body weight, BMI, waist circumference (WC), blood lipids and high-sensitivity C-reactive protein (Hs-CRP) in overweight and obese individuals.…”

Section: Introductionmentioning

confidence: 99%

Effect of aerobic exercise on echocardiographic epicardial adipose tissue thickness in overweight individuals

Bairapareddy¹,

Maiya²,

Kumar³

et al. 2018

DMSO

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BackgroundEpicardial adipose tissue thickness (EATT) measured by echocardiography is a reliable indicator of visceral adipose tissue in the body and metabolic syndrome. The objective of this work was to study the effect of 12-week aerobic exercise training on echocardiographic epicardial adipose tissue thickness (EEATT), body composition and other metabolic parameters in asymptomatic overweight adults.MethodsA total of 170 overweight and mild obese individuals were randomly allocated to 12-week aerobic exercise program (intervention group) or no supervised exercise (control group). The body fat percentage and visceral fat levels were measured by bioelectric impedance analyzer, and blood tests were conducted to measure lipids, fasting blood sugar (FBS) and high-sensitivity C-reactive protein (Hs-CRP). The participants also underwent transthoracic echocardiography to measure EATT. All the outcomes were measured after 12 weeks. Repeated measures were analyzed using ANOVA and Mann–Whitney U-test were used to analyze the data.ResultsEEATT values significantly reduced by −16.24% (3.12±1.18 to 2.70±1.04, p<0.05) following 12 weeks of aerobic exercise along with a reduction in weight by 2.96% (80.66±12.12 to 78.27±12.31, p<0.05), body mass index by 3.11% (29.20±2.71 to 28.29±2.81, p<0.05) and waist circumference by 2.29% (94.82±7.23 to 92.64±7.33, p<0.05) and improved Hs-CRP values.ConclusionThe 12-week aerobic exercise was found to be effective in reducing EEATT in overweight and mild obese individuals. There was significant improvement in body composition, blood lipids, FBS, Hs-CRP and exercise capacity in intervention group compared to control group.

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Effects of lifestyle intervention on left ventricular regional myocardial function in metabolic syndrome patients from the RESOLVE randomized trial

Cited by 24 publications

References 37 publications

Dietary Fibres and the Management of Obesity and Metabolic Syndrome: The RESOLVE Study

Dietary Fibres and the Management of Obesity and Metabolic Syndrome: The RESOLVE Study

Cardiovascular risk of adipokines: a review

Effect of aerobic exercise on echocardiographic epicardial adipose tissue thickness in overweight individuals

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