Effects of Lifestyle on Hemostasis, Fibrinolysis, and Platelet Reactivity

Lee, Kaeng W.; Lip, Gregory Y.H.

doi:10.1001/archinte.163.19.2368

Cited by 215 publications

(175 citation statements)

References 282 publications

(246 reference statements)

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“…Some previous studies showed an inverse association between omega-3 PFA and plasma fibrinogen, although these findings have been inconsistent. 23 In our study, higher omega-3 PFA intake in Japanese in Japan did not independently explain lower fibrinogen levels in Japan. This may be because of a relatively small difference in omega-3 PFA intake across the samples from Japan and Hawaii, with fish intake relatively high at both sites.…”

Section: Discussioncontrasting

confidence: 58%

“…To the best of our knowledge, there is no previous report on a relationship between sugar intake and plasma fibrinogen. 23 A recent study reported an association between high dietary glycemic load and elevated C-reactive protein. 25 Inflammation may result from recurrent postprandial hyperglycemia, hyperinsulinemia, and insulin resistance that may occur with long-term high dietary glycemic load.…”

Section: Discussionmentioning

confidence: 99%

“…23 Findings on coffee or tea consumption tend to be confounded because coffee and tea contain other nutrients such as flavonoids. Further studies on caffeine and fibrinogen are needed.…”

Section: Discussionmentioning

confidence: 99%

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Dietary Factors Related to Higher Plasma Fibrinogen Levels of Japanese-Americans in Hawaii Compared With Japanese in Japan

Miura

Nakagawa

Ueshima

et al. 2006

ATVB

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Objective-We investigated whether dietary factors explain higher plasma fibrinogen levels in Japanese emigrants living a Western lifestyle in Hawaii compared with Japanese in Japan. Methods and Results-Plasma fibrinogen and nutrient intakes were examined by standardized methods in men and women 40 to 59 years of age from a Japanese-American sample in Hawaii (100 men and 106 women) and 4 population samples in Japan (569 men and 567 women). Multiple linear regression models were used to examine the relationship between dietary factors and the plasma fibrinogen difference between Hawaii and Japan. Average plasma fibrinogen was significantly higher in Hawaii compared with Japan (PϽ0.001 in both genders). In multiple linear regression analyses with each dietary variable considered separately, body mass index reduced the plasma fibrinogen difference between Hawaii and Japan by 20.4%; iron intake (mg/1000 kcal) and estimated total sugar intake (%kcal) reduced this difference by 30.0% and 14.4%, respectively. In a model that included body mass index, iron, estimated total sugars, and caffeine (also age and gender), this difference was reduced by 61.3% (from 42.2 to 16.3 mg/dL). Conclusions-Higher intake of iron, sugar, and caffeine, in addition to obesity, account largely for higher fibrinogen levels Key Words: fibrinogen Ⅲ nutrition Ⅲ iron Ⅲ sugar Ⅲ caffeine Ⅲ obesity Ⅲ population study J apanese living in Japan have lower rates of coronary heart disease (CHD) than people in the United States and other Western countries, 1,2 including Japanese-Americans living in Hawaii. 3,4 In recent decades, these trends appear to have continued despite higher smoking rates, higher blood pressure levels, and increasing serum cholesterol levels in Japan with a more Westernized lifestyle. 1,5 Investigation of factors possibly affecting the CHD risk difference among genetically similar Japanese populations living in Japan and Hawaii is of interest in understanding these differences.Elevated plasma fibrinogen level has been identified as a risk factor for CHD and stroke in both Western and Japanese populations. 6 -8 A previous study found plasma fibrinogen levels among 75-to 93-year-old Japanese men living in Japan to be significantly lower than those among Japanese of similar age living in Hawaii. 9 Factors contributing to this difference remain unclear; few data are available on the role of dietary factors.Here we report standardized comparisons of plasma fibrinogen and dietary factors between Japanese living in Japan and Japanese-Americans living a primarily Western lifestyle in Hawaii, from the INTERLIPID study, an ancillary investigation of the INTERMAP study on diet and blood pressure. We assessed whether dietary factors account for the difference in fibrinogen levels. MethodsINTERMAP is an international cooperative study on relationships between multiple dietary factors and blood pressure among 4680 participants 40 to 59 years of age from 17 diverse population samples in China, Japan, the United Kingdom, and the United States. INT...

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Section: Discussioncontrasting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

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Dietary Factors Related to Higher Plasma Fibrinogen Levels of Japanese-Americans in Hawaii Compared With Japanese in Japan

Miura

Nakagawa

Ueshima

et al. 2006

ATVB

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“…In our study, however, we found a decrease in PAI-1 both in the lifestyle intervention group that continued metformin treatment and in the group that stopped metformin and combined lifestyle intervention with insulin treatment. Other studies have consistently reported significantly decreased PAI-1 levels following regular exercise and there is ample evidence that weight reduction reduces PAI-1 and tissue-type plasminogen activator antigen levels in non-diabetic subjects [47]. Still there is a risk that stopping metformin in groups L+I and I may have contributed to the differences between these groups and group L at the end of the study.…”

Section: Discussionmentioning

confidence: 89%

Blood glucose lowering by means of lifestyle intervention has different effects on adipokines as compared with insulin treatment in subjects with type 2 diabetes

Aas¹,

Seljeflot

Torjesen

et al. 2006

Diabetologia

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“…Benefits to the circulatory system include influences on the lipoprotein metabolism, inflammatory markers, endothelial function and insulin resistance. [39][40][41][42][43][44][45][46] Is physical activity important among those who lose weight? Our study showed that leisure time physical activity had protective effect on all-cause mortality, which is in line with numerous other studies.…”

Section: Discussionmentioning

confidence: 99%

Combined effects of weight loss and physical activity on all-cause mortality of overweight men and women

et al. 2010

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Effects of Lifestyle on Hemostasis, Fibrinolysis, and Platelet Reactivity

Cited by 215 publications

References 282 publications

Dietary Factors Related to Higher Plasma Fibrinogen Levels of Japanese-Americans in Hawaii Compared With Japanese in Japan

Dietary Factors Related to Higher Plasma Fibrinogen Levels of Japanese-Americans in Hawaii Compared With Japanese in Japan

Blood glucose lowering by means of lifestyle intervention has different effects on adipokines as compared with insulin treatment in subjects with type 2 diabetes

Combined effects of weight loss and physical activity on all-cause mortality of overweight men and women

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