Business traveling is attracting growing attention due to the expansion of international markets. This fact calls for an increasing attention of the tourism sector toward the needs of business travellers, who often require services that are different from the ones desired by leisure tourists. The application of smart solutions coming from Context Awareness and Ambient Intelligence aimed at promoting guests' comfort and well-being, also in cases in which they have special needs, represents a promising solution to tackle business travellers' requirements and thus, to increase hotels attractiveness and incomes. In this context, this work introduces RoomFort, a smart comfort management system aimed at enhancing comfort of hotel room guests and leveraging on semantic representations of comfort, environment, and sensors. RoomFort provides a set of domain ontologies to formalize comfort-related metrics and to exploit the automatic reasoning capabilities provided by Semantic Web technologies, while gathering data through a network of sensors to ensure guests are provided with tailored comfort profiles during their stays in the hotel. Particular focus has been placed on visual comfort, since indoor lighting features constitute one of the main factors influencing the two main activities that most business travellers accomplish in their hotel room: working and relaxing.