Effects of lime (Citrus aurantifolia) peel to the expression of mRNA toll-like receptors 4 in balb/c mice-infected Salmonella typhi

Kasim, Vivien novarina a; Hatta, Mochammad; Natzir, Rosdiana; Hadju, Veni; Febriza, Ami; Idrus, Hasta Handayani

doi:10.4103/japtr.japtr_48_20

Cited by 4 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This shows that C. aurantifolia extract can be used as an effective therapeutic agent in the treatment of acute inflammation [51]. Besides that, Kasim et al (2020) [67] proved that the ethanolic extract of C. aurantifolia bark affected growth mediated by the IL-6 activity of S. typhi bacteria in Balb/c mice. IL-6 pro-inflammatory cytokinin activity increased on day five after injection of S. typhi and decreased after intervention on day ten.…”

Section: Anti-inflammatorymentioning

confidence: 94%

“…When compared to seeds, juice, and fruit, the fruit peel contains the most flavonoids in C. aurantifolia, including the mesocarp, epicarp, and layer segments [67]. Flavonoid content ranges from 41.38-64.2 µg of QE/mg of methanol dry extract [11].…”

Section: Flavonoidsmentioning

confidence: 99%

“…The speed of decrease in IL-6 level was the greatest at the lime peel extract with a concentration of 750 mg/kg body weight. This shows that C. aurantifolia extract has the potential to be antibacterial and anti-inflammatory by reducing serum levels of IL-6, which can inhibit the growth of S. typhi [67]. Wardani et al (2017) [120] also stated that the ethanolic extract of C. aurantifolia could improve the healing of traumatic ulcers with an optimum concentration of 25-50%, which was carried out in vitro against the Rattus norvegicus Wistar strain.…”

Section: Anti-inflammatorymentioning

confidence: 99%

See 2 more Smart Citations

Bioactive Components and Their Activities from Different Parts of Citrus aurantifolia (Christm.) Swingle for Food Development

Indriyani

Anshori

Permadi

et al. 2023

Foods

View full text Add to dashboard Cite

Citrus aurantifolia is part of the Rutaceae family and belongs to the genus Citrus. It is widely used in food, the chemical industry, and pharmaceuticals because it has a unique flavor and odor. It is nutrient-rich and is beneficial as an antibacterial, anticancer, antioxidant, anti-inflammatory, and insecticide. Secondary metabolites present in C. aurantifolia are what give rise to biological action. Flavonoids, terpenoids, phenolics, limonoids, alkaloids, and essential oils are among the secondary metabolites/phytochemicals discovered in C. aurantifolia. Every portion of the plant’s C. aurantifolia has a different composition of secondary metabolites. Environmental conditions such as light and temperature affect the oxidative stability of the secondary metabolites from C. aurantifolia. The oxidative stability has been increased by using microencapsulation. The advantages of microencapsulation are control of the release, solubilization, and protection of the bioactive component. Therefore, the chemical makeup and biological functions of the various plant components of C. aurantifolia must be investigated. The aim of this review is to discuss the bioactive components of C. aurantifolia such as essential oils, flavonoids, terpenoids, phenolic, limonoids, and alkaloids obtained from different parts of the plants and their biological activities such as being antibacterial, antioxidant, anticancer, an insecticide, and anti-inflammatory. In addition, various extraction techniques of the compounds out of different parts of the plant matrix as well as the microencapsulation of the bioactive components in food are also provided.

show abstract

Section: Anti-inflammatorymentioning

confidence: 94%

Section: Flavonoidsmentioning

confidence: 99%

Section: Anti-inflammatorymentioning

confidence: 99%

See 1 more Smart Citation

Bioactive Components and Their Activities from Different Parts of Citrus aurantifolia (Christm.) Swingle for Food Development

Indriyani

Anshori

Permadi

et al. 2023

Foods

View full text Add to dashboard Cite

show abstract

“…Numerous studies have examined the use and effects of traditional medicines for various diseases [ [1] , [2] , [3] , [4] , [5] ], including the effects of herbal medicines on infectious diseases, such as candidiasis [ [6] , [7] , [8] ], typhoid fever [ [9] , [10] , [11] , [12] , [13] , [14] ], toxoplasmosis [ [15] , [16] , [17] ], gingivitis [ 18 , 19 ], vaginitis [ 20 ], and the human immunodeficiency virus (HIV) [ 21 , 22 ], and noninfectious diseases such as diabetes [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

In vivo and in vitro inhibition effect of propolis on Klebsiella pneumoniae : A review

Taufik¹,

Natzir²,

Patellongi³

et al. 2022

Annals of Medicine &Amp; Surgery

Self Cite

View full text Add to dashboard Cite

“…Previously, study revealed that the effect of immunomodulator and immune responses on Miana leaves for infectious diseases [ [11] , [12] , [13] ]. Immunomodulator parameter such as T lymphocyte, CD4 T cell, IFN-γ and TNF-α and other cytokines were measured after herbal medicine treated in infection of human and animal model [ [14] , [15] , [16] ].…”

Section: Introductionmentioning

confidence: 99%

Increasing Natural Resistance Associated Macrophage Protein 1 serum level after Miana treatment in BALB/c induced Klebsiella pneumoniae experimental research

Wahyuni

Hatta

Bukhari

et al. 2021

Annals of Medicine &Amp; Surgery

Self Cite

View full text Add to dashboard Cite

Background Miana ( Coleus Scutellariodes [L] Benth) inhibits growth of bacterial pathogen inside macrophage. Objective The aim of this study is to determine the protein level of Natural Resistance Associated Macrophage Protein 1 (NRAMP1), after administration of Miana extracts in BALB/c mice induced Klebsiella pneumoniae . Methods This is an experimental study using animal model with post test-only controlled group design. Twenty healthy adult male BALB/c mice were randomly divided into four groups, negative control group (distilled water), Levofloxacin 100 mg/kg, injection intraperitoneal, first treatment group (Miana leaves extract/MLE 510 mg/kg) and second treatment group (Miana + levofloxacin). MLE were administered via gastric gavage for ten consecutive days. The blood was drawn from each mice on the first day, on the eight day of experiment (2 h after treatment), and at 10 days. The blood sample was examined by ELISA to determine the NRAMP1 protein level. Analysis of the number of lung tissue bacteria used Plate count agar to see the growth of Klebsiella pneumonia . Results NRAMP1 protein level in BALB/c mice after administration of Miana extract was increased significantly in after 10 days treatment (p < 0.0001). The highest increasing in protein levels was found in treatment group (Miana + levofloxacin) with an increase before treatment 3036,07 to 10010,30 pg/ml after treatment p < 0,0001. Conclusion NRAMP1 protein level in BALB/c mice were highest increasing in protein levels after administration of Miana extract and Levofloxacin compared Miana or Levofloxacin only and clinical impact proved a comparable effect on suppressing Klebsiella pneumoniae growth. The institutional protocol number of this study is 1010/UN4.6.4.5.31/PP36/2019.

show abstract

Effects of lime (Citrus aurantifolia) peel to the expression of mRNA toll-like receptors 4 in balb/c mice-infected Salmonella typhi

Cited by 4 publications

References 13 publications

Bioactive Components and Their Activities from Different Parts of Citrus aurantifolia (Christm.) Swingle for Food Development

Bioactive Components and Their Activities from Different Parts of Citrus aurantifolia (Christm.) Swingle for Food Development

In vivo and in vitro inhibition effect of propolis on Klebsiella pneumoniae : A review

Increasing Natural Resistance Associated Macrophage Protein 1 serum level after Miana treatment in BALB/c induced Klebsiella pneumoniae experimental research

Contact Info

Product

Resources

About